{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:29:26Z","timestamp":1794000566346,"version":"4.8.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"12","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>:<\/jats:title>\n                    <jats:p>Among all the parasitic diseases in humans, malaria is the most significant and malicious\none. The widespread species are Plasmodium falciparum and Plasmodium vivax, but the infection\ncaused by the former is the deadliest. According to the November 2018 report of the World Health\nOrganization (WHO), a total of 219 million cases of malaria were reported globally in 2017, which\nled to an estimated 435,000 deaths. Mortality due to malaria is estimated at 1.5 - 2.7 million deaths each\nyear. Among all the complications associated with Plasmodium falciparum infection, cerebral malaria (CM)\nis the most fretful, accounting for almost 13% of all malaria-related deaths. CM is a medical emergency that\nrequires immediate clinical testing and treatment. A compromised microcirculation, with sequestration of\nparasitized erythrocytes, is central in the disease pathology. No effective therapeutic agents are\navailable yet for the treatment of CM, and therefore, potential interventions are needed to be\ndeveloped urgently. The currently available anti-malarial drugs lack lipophilicity and are thus\nnot able to reach the brain tissues. Therefore, safe, cost-effective agents with improved lipophilicity\npossessing the potential to target brain tissues are needed to be searched in order to fight CM worldwide.\nThe aim of present review is to systematically revise the published research work available concerning\nthe development and evaluation of some potential drug targets in the management of CM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389557521666211124143117","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T23:16:56Z","timestamp":1637795816000},"page":"1607-1618","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Update on Recent Advances for the Treatment of Cerebral Malaria"],"prefix":"10.2174","volume":"22","author":[{"given":"Deepika","family":"Purohit","sequence":"first","affiliation":[{"name":"School of Medical and Allied Sciences, G.D.\nGoenka University, Sohna-Gurgaon Road, Sohna, 122103, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Delhi Pharmaceutical\nSciences and Research University, New Delhi, 110017, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Dutt","sequence":"additional","affiliation":[{"name":"School of Medical and Allied Sciences, G.D.\nGoenka University, Sohna-Gurgaon Road, Sohna, 122103, Gurugram, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilak Raj","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"School of Pharmacy &amp; Emerging Sciences, Baddi\nUniversity of Emerging Sciences &amp; Technology, Baddi-173205, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1389557521666211124143117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/198280\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1389557521666211124143117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:24:29Z","timestamp":1658478269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/198280\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389557521666211124143117","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}