{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T08:46:16Z","timestamp":1649061976912},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2021,9,23]]},"abstract":"<jats:sec>\n<jats:title \/>\n<jats:p>Pluripotent stem cells of the bone marrow are stimulated by different cytokines to proliferation\nand differentiation into various types of blood cells. These cytokines are mostly glycoproteins.\nErythropoietin stimulates stem cells to the formation of erythrocytes while colony-stimulating factors\ncause the formation of different types of white blood cells. Stem cell factors play an important role in\nthe maintenance and survival of blood cells of all types. Thrombopoietin stimulates stem cells to proliferation\nand formation of blood platelets. Granulocyte colony-stimulating factor is probably the most\nimportant drug in use. It stimulates stem cells to the formation of neutrophile granulocytes. It is often\nused in recombinant forms such as filgrastim in the treatment of neutropenia in cancer chemotherapy\nor AIDS. Its pegylated conjugates such as pegfilgrastim are also available. Its activity can be supported\nby plerixafor, a small molecule \u2013 bicyclam derivative acting as an indirect agonist of stem cells\nfactor. It acts as an antagonist of CXCR4 receptor activation of which brakes hematopoiesis. The\ntreatment of conditions accompanied by thrombocytopenia such as idiopathic thrombocytopenic purpura\nis currently not performed by thrombopoietin but synthetic agonists of its receptor are preferred.\nRomiplostim is a peptibody. It consists of a protein part interacting with the thrombopoietin receptor\nwhich is, however, different from thrombopoietin, and of Fc fragment of immunoglobulin G1. In contrast,\nsmall molecule thrombopoietin receptor agonists represented by eltrombopag can be given orally\nunlike all of the above.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1389557521999201230195926","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T07:53:18Z","timestamp":1609487598000},"page":"1638-1645","update-policy":"http:\/\/dx.doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protein and Small-Molecule Leucopoiesis and Thrombopoiesis Stimulators"],"prefix":"10.2174","volume":"21","author":[{"given":"Old\u0159ich","family":"Farsa","sequence":"first","affiliation":[{"name":"Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Zub\u00e1\u010d","sequence":"additional","affiliation":[{"name":"Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189654\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T13:56:00Z","timestamp":1632491760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189654\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":0,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,9,23]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1389557521999201230195926","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,23]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}