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Recent studies have focused on the role of mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT), the extracellular matrix (ECM), chemokines, cancer stem cells, and non-coding RNAs in DLBCL. Here, we have summarised the advances and challenges in the investigation of metastasis in DLBCL and attempted to reveal the potential targets that can improve patient survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1389557522666220519085134","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T06:42:15Z","timestamp":1653028935000},"page":"2808-2812","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advances and Challenges in the Investigation of Metastasis in Diffuse\nLarge B-Cell Lymphoma"],"prefix":"10.2174","volume":"22","author":[{"given":"Yingying","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiming","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Hematology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China"},{"name":"Anhui Provincial Institute of Translational\nMedicine, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of hematology, The fourth affiliated hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Emergency, The\nThird Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.3324\/haematol.2020.268235","volume":"106","author":"Youssef Y.","year":"2021","unstructured":"Youssef Y.; Karkhanis V.; Chan W.K.; Jeney F.; Canella A.; Zhang X.; Sloan S.; Prouty A.; Helmig-Mason J.; Tsyba L.; Hanel W.; Zheng X.; Zhang P.; Chung J.H.; Lucas D.M.; Kauffman Z.; Larkin K.; Strohecker A.M.; Ozer H.G.; Lapalombella R.; Zhou H.; Xu-Monette Z.Y.; Young K.H.; Han R.; Nurmemmedov E.; Nuovo G.; Maddocks K.; Byrd J.C.; Baiocchi R.A.; Alinari L.; Transducin &#x3B2;-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma Haematologica 2021,106(11),2927-2939","journal-title":"Haematologica"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.3109\/10428194.2010.504872","volume":"51","author":"Hui D.","year":"2010","unstructured":"Hui D.; Proctor B.; Donaldson J.; Shenkier T.; Hoskins P.; Klasa R.; Savage K.; Chhanabhai M.; Gascoyne R.D.; Connors J.M.; Sehn L.H.; Prognostic implications of extranodal involvement in patients with diffuse large B-cell lymphoma treated with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone. 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