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In the field of medicine, especially in pediatrics, knowledge\nabout autoimmune diseases is still inadequate. Some common juvenile autoimmune diseases\nsuch as Henoch\u2013Schonlein purpura, systemic juvenile idiopathic arthritis, mucocutaneous lymph node\nsyndrome, and autoimmune encephalitis cause considerable public concern. Recent studies revealed\nthat heme oxygenase 1 (HO-1), an enzyme that participates in heme degradation, plays a critical role\nin the pathogenesis and may regulate autoimmunity. Firstly, it may promote the differentiation of T\nlymphocytes into CD4+CD25+ regulatory T cells and may be associated with changes in the ratios of\ncytokines (Th1\/Th2 and Th17\/Treg) as well. Secondly, HO-1 can regulate the immune system through\nthe secretion of proteins such as transforming growth factors and interleukins. Moreover, increasing\nthe expression of HO-1 can improve vascular function by increasing antioxidant levels. Thus, HO-1\nmay provide a theoretical basis and guidance for therapeutic management of juvenile autoimmune diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1566523219666190710092935","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T03:00:01Z","timestamp":1562727601000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Functional Immunoregulation by Heme Oxygenase 1 in Juvenile Autoimmune Diseases"],"prefix":"10.2174","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-7926","authenticated-orcid":true,"given":"Xueyan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-2937","authenticated-orcid":true,"given":"Shupeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-6488","authenticated-orcid":true,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-0736","authenticated-orcid":true,"given":"Mingyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-9583","authenticated-orcid":true,"given":"Qingnan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1089\/ars.2013.5675","volume":"20","author":"Dunn L.L.","year":"2014","unstructured":"Dunn L.L.; Midwinter R.G.; Ni J.; Hamid H.A.; Parish C.R.; Stocker R.; New insights into intracellular locations and functions of heme oxygenase-1. 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