{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:34:36Z","timestamp":1778186076315,"version":"3.51.4"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"4","funder":[{"DOI":"10.13039\/501100004716","name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food","doi-asserted-by":"publisher","award":["(SZ2017ZX06)"],"award-info":[{"award-number":["(SZ2017ZX06)"]}],"id":[{"id":"10.13039\/501100004716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004716","name":"Back-up Candidates for Academic and Technical Leaders of Suzhou University","doi-asserted-by":"publisher","award":["(2018XJHB06"],"award-info":[{"award-number":["(2018XJHB06"]}],"id":[{"id":"10.13039\/501100004716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004716","name":"Back-up Candidates for Academic and Technical Leaders of Suzhou University","doi-asserted-by":"publisher","award":["2018XJGG02)"],"award-info":[{"award-number":["2018XJGG02)"]}],"id":[{"id":"10.13039\/501100004716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010246","name":"Postdoctoral Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["(1601173B)"],"award-info":[{"award-number":["(1601173B)"]}],"id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012259","name":"Academic Foundation of Disciplines (Specialties","doi-asserted-by":"publisher","award":["(gxbjZD44)"],"award-info":[{"award-number":["(gxbjZD44)"]}],"id":[{"id":"10.13039\/501100012259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Major Natural Science Foundation of Anhui Educational Committee","doi-asserted-by":"publisher","award":["(KJ2018ZD044"],"award-info":[{"award-number":["(KJ2018ZD044"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Major Natural Science Foundation of Anhui Educational Committee","doi-asserted-by":"publisher","award":["KJ2018A0443"],"award-info":[{"award-number":["KJ2018A0443"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Major Natural Science Foundation of Anhui Educational Committee","doi-asserted-by":"publisher","award":["KJ2015A220"],"award-info":[{"award-number":["KJ2015A220"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["1608085QH185"],"award-info":[{"award-number":["1608085QH185"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"Focus on Research and Development Projects in Anhui Province","doi-asserted-by":"publisher","award":["1804a0802225"],"award-info":[{"award-number":["1804a0802225"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601034"],"award-info":[{"award-number":["81601034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2019,6,10]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Compound Fengshiding capsule (CFC), is a Chinese formulation from herbal origin including Alangium platanifolium, Angelicae dahurica, Cynanchum paniculatum and Glycyrrhiza uralensis. CFC is widely used as clinical therapy against rheumatoid arthritis. However, its exact mechanism of action has not been explored yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>In order to explore the synergistic mechanism of CFC, we designed a study adopting network pharmacology scheme to screen the action targets in relation to the CFC components. The study analyses target facts of salicin, paeonol, liquiritin and imperatorin from PubMed database, and explores the potential pharmacological targets of rheumatoid arthritis, cervical neuralgia and sciatica related diseases for their interaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The results of boosted metabolic pathway showed that the chemical components of CFC interrupted many immune-related pathways, thus participating in immunity regulation of the body and playing a role in the treatment of rheumatism. Collectively, CFC has apoptotic, oxidative stress modulatory and anti-inflammatory effects that accumulatively serve for its clinical application against rheumatoid arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Conclusively, our findings from present study reconnoiters and compacts systematic theoretical approach by utilizing the network pharmacology mechanism of four effective components for the treatment of rheumatism indicating sufficient potential drug targets associated with CFC against rheumatism. These interesting findings entreaties for further in vitro and in vivo studies on the mechanism of compound active ingredient against rheumatism.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1566524019666190405094125","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T12:23:28Z","timestamp":1554467008000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Revealing the Synergistic Mechanism of Multiple Components in Compound Fengshiding Capsule for Rheumatoid Arthritis Therapeutics by Network Pharmacology"],"prefix":"10.2174","volume":"19","author":[{"given":"Hong","family":"Duan","sequence":"first","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-feng","family":"Zhai","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam J.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Faculty of Pharmacy, University of Central Punjab, Lahore, 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-yan","family":"Cao","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-qi","family":"Wu","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-ru","family":"Zhou","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-gen","family":"Cao","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-zhen","family":"Gao","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-ling","family":"Shan","sequence":"additional","affiliation":[{"name":"Suzhou Engineering and Technological Research Center of Natural Medicine and Functional Food, Institute of Pharmaceutical Biotechnology, School of Biological and Food Engineering, Suzhou University, 49, Bianhe Road, Suzhou, 234000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10787-017-0385-5","volume":"25","author":"Zhai K.F.","year":"2017","unstructured":"Zhai KF, Duan H, Luo L. Protective effects of paeonol on inflammatory response in IL-1beta-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-kappaB pathway.","journal-title":"Inflammopharmacol"},{"key":"ref=2","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1039\/C7FO01748K","volume":"9","author":"Zhai K.F.","year":"2018","unstructured":"Zhai KF, Duan H, Chen Y. Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial\/caspase-mediated pathways.","journal-title":"Food Funct"},{"key":"ref=3","doi-asserted-by":"crossref","first-page":"15924","DOI":"10.1038\/s41598-018-34061-y","volume":"8","author":"Zhang Y.","year":"2015","unstructured":"Zhang Y, Bai M, Zhang B. Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation.","journal-title":"Sci Rep"},{"key":"ref=4","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2177\/jsci.34.493","volume":"34","author":"Nanke Y.","year":"2011","unstructured":"Nanke Y, Yago T, Kotake S. The effects of disease modifying anti-rheumatic drugs on osteoclastogenesis and bone destruction in rheumatoid arthritis.","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1093\/rheumatology\/kes198","volume":"51","author":"Bohler C.","year":"2012","unstructured":"Bohler C, Radner H, Ernst M. Rheumatoid arthritis and falls: the influence of disease activity.","journal-title":"Rheumatology"},{"key":"ref=6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s40264-014-0250-z","volume":"38","author":"Liu S.H.","year":"2015","unstructured":"Liu SH, Chuang WC, Lam W, Jiang Z, Cheng YC. Safety surveillance of traditional Chinese medicine: Current and future.","journal-title":"Drug Saf"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jep.2015.10.010","volume":"176","author":"Lu S.","year":"2015","unstructured":"Lu S, Wang Q, Li G, Sun S, Guo Y, Kuang H. The treatment of rheumatoid arthritis using Chinese medicinal plants: From pharmacology to potential molecular mechanisms.","journal-title":"J Ethnopharmacol"},{"key":"ref=8","doi-asserted-by":"crossref","first-page":"S631","DOI":"10.5530\/ijper.51.4s.92","volume":"51","author":"Duan H.","year":"2017","unstructured":"Duan H, Zhai KF, Cao WG, Gao GZ, Shan LL, Zhao L. The Optimum Extraction Process for Radix glycyrrhizae and Angelica dahurica (Fisch.) Benth.et Hook with Orthogonal Design.","journal-title":"Indian J Pharm Edu Res"},{"key":"ref=9","first-page":"445","volume":"76","author":"Zhai K.","year":"2014","unstructured":"Zhai K, Gao G, Cao W, Zhao L, Fang X, Duan H. Simultaneous HPLC determination of four active compounds in fengshiding capsules, a chinese medicine.","journal-title":"Indian J Pharm Sci"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12906-016-1268-9","volume":"16","author":"Shen P.","year":"2016","unstructured":"Shen P, Shen J, Sun C. A system biology approach to understanding the molecular mechanisms of Gubentongluo decoction acting on IgA Nephropathy.","journal-title":"BMC Complement Altern Med"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.chroma.2006.02.081","volume":"1115","author":"Wei Y.","year":"2006","unstructured":"Wei Y, Ito Y. Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from traditional Chinese herb \u201cbai zhi\u201dAngelica dahurica (Fisch. ex Hoffm) Benth. et Hook using multidimensional high-speed counter-current chromatography.","journal-title":"J Chromatogr A"},{"key":"ref=12","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1021\/acs.jafc.8b02241","volume":"66","author":"Zhai K.F.","year":"2018","unstructured":"Zhai KF, Duan H, Khan GJ. Salicin from Alangium chinense Ameliorates Rheumatoid Arthritis by Modulating the Nrf2-HO-1-ROS Pathways.","journal-title":"J Agric Food Chem"},{"key":"ref=13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phymed.2017.09.009","volume":"36","author":"Wei P.","year":"2017","unstructured":"Wei P, Zhang T, Dong H. Anti-inflammatory and antiviral activities of cynanversicoside A and cynanversicoside C isolated from Cynanchun paniculatum in influenza A virus-infected mice pulmonary microvascular endothelial cells.","journal-title":"Phytomedicine"},{"key":"ref=14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00572-018-0827-y","volume":"28","author":"Xie W.","year":"2018","unstructured":"Xie W, Hao Z, Zhou X. Arbuscular mycorrhiza facilitates the accumulation of glycyrrhizin and liquiritin in Glycyrrhiza uralensis under drought stress.","journal-title":"Mycorrhiza"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1021\/acs.jafc.9b00185","volume":"67","author":"Zhai K.F.","year":"2019","unstructured":"Zhai KF, Duan H, Cui CY. Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway.","journal-title":"J Agric Food Chem"},{"key":"ref=16","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1039\/C3MB70507B","volume":"10","author":"Liang X.","year":"2014","unstructured":"Liang X, Li H, Li S. A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study.","journal-title":"Mol Biosyst"},{"key":"ref=17","first-page":"696","volume":"47","author":"Liu Z.H.","year":"2012","unstructured":"Liu ZH, Sun XB. [Network pharmacology: new opportunity for the modernization of traditional Chinese medicine].","journal-title":"Yao Xue Xue Bao"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"27007","DOI":"10.18632\/oncotarget.15351","volume":"8","author":"Mao Y.","year":"2017","unstructured":"Mao Y, Hao J, Jin ZQ. Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients.","journal-title":"Oncotarget"},{"key":"ref=19","first-page":"251","volume":"12","author":"Lv Y.N.","year":"2014","unstructured":"Lv YN, Li SX, Zhai KF, Kou JP, Yu BY. Network pharmacology-based prediction and verification of the molecular targets and pathways for schisandrin against cerebrovascular disease.","journal-title":"Chin J Nat Med"},{"key":"ref=20","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2105-11-S11-S6","volume":"11","author":"Li S.","year":"2010","unstructured":"Li S, Zhang B, Jiang D, Wei Y, Zhang N. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae.","journal-title":"BMC Bioinformatics"},{"key":"ref=21","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/aps.2015.70","volume":"36","author":"Li F.","year":"2015","unstructured":"Li F, Lv YN, Tan YS. An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases.","journal-title":"Acta Pharmacol Sin"},{"key":"ref=22","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"Hopkins A.L.","year":"2007","unstructured":"Hopkins AL. Network pharmacology.","journal-title":"Nat Biotechnol"},{"key":"ref=23","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"Hopkins A.L.","year":"2008","unstructured":"Hopkins AL. Network pharmacology: the next paradigm in drug discovery.","journal-title":"Nat Chem Biol"},{"key":"ref=24","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.12659\/MSM.904264","volume":"23","author":"Wang N.","year":"2017","unstructured":"Wang N, Zhao G, Zhang Y. A network pharmacology approach to determine the active components and potential targets of curculigo orchioides in the treatment of osteoporosis.","journal-title":"Med Sci Monit"},{"key":"ref=25","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1136\/ard.2007.086421","volume":"68","author":"Roelofs M.F.","year":"2009","unstructured":"Roelofs MF, Wenink MH, Brentano F. Type I interferons might form the link between Toll-like receptor (TLR) 3\/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA).","journal-title":"Ann Rheum Dis"}],"container-title":["Current Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/171304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T15:33:56Z","timestamp":1607182436000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/171304\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,6,10]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1566524019666190405094125","relation":{},"ISSN":["1566-5240"],"issn-type":[{"value":"1566-5240","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,10]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2018-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}