{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:01:47Z","timestamp":1767888107018,"version":"3.49.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2020,3,20]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Celiac Disease (CD) is a complex immunogenic disease mainly triggered by\ngluten intake in genetically susceptible individuals with a prevalence of 1 in 100-300. CD\nresults from the interplay between genetic and environmental factors. Genetic\nsusceptibility is believed to play a prominent role in the pathogenicity of CD, mainly due\nto human leukocyte antigen (HLA)-related class II genes. Although CD is wellrecognized\namong Arab populations, there are few studies on the genetic epidemiology\nand prevalence of CD in the Arab countries. Therefore, the aim of this review was to\nhighlight the importance of studying this disease in the Arab world in the context of a\nglobal perspective. Within the few studies published so far, it was found that Arab\npopulations have a distinctive susceptibility genetic profile from other ethnic groups with\nthe DQ2.5 and DQ8 genotypes that are considered the major genotypes that confer\nsusceptibility among Arab patients with CD. Our findings will pave the way to perform\nfurther epidemiological studies that will help identify potential therapeutic targets against\nCD among Arab patients that are diagnosed with CD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1566524019666191024104930","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T10:09:45Z","timestamp":1572257385000},"page":"275-285","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immunogenetics of Celiac Disease: A Focus on Arab Countries"],"prefix":"10.2174","volume":"20","author":[{"given":"Nadin","family":"Younes","sequence":"first","affiliation":[{"name":"College of Health Sciences, Biomedical Sciences Department, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Younes","sequence":"additional","affiliation":[{"name":"College of Health Sciences, Biomedical Sciences Department, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola. A.","family":"Alsharabasi","sequence":"additional","affiliation":[{"name":"College of Health Sciences, Biomedical Sciences Department, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed E.","family":"El Zowalaty","sequence":"additional","affiliation":[{"name":"Virology and Microbiology Research Group, College of Pharmacy, City University College of Ajman, Ajman, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Mustafa","sequence":"additional","affiliation":[{"name":"College of Health Sciences, Biomedical Sciences Department, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Jahromi","sequence":"additional","affiliation":[{"name":"Clinical Research, Clinical Services Division, Dasman Diabetes Institute, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Uddin","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Al-Nesf","sequence":"additional","affiliation":[{"name":"Academic health system, Translational research institute, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Pintus","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, University of Sharjah, 27272 2 Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-6638","authenticated-orcid":true,"given":"Hatem","family":"Zayed","sequence":"additional","affiliation":[{"name":"College of Health Sciences, Biomedical Sciences Department, Qatar University, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/176114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T09:37:38Z","timestamp":1584697058000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/176114\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,3,20]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1566524019666191024104930","relation":{},"ISSN":["1566-5240"],"issn-type":[{"value":"1566-5240","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,20]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}