{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:21:24Z","timestamp":1759742484808,"version":"3.40.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2020,12,29]]},"abstract":"<jats:sec>\n<jats:title>Aims:<\/jats:title>\n<jats:p>The aim of this study was to investigate MacroH2A.1 immunoexpression\nin tissues of sheep exposed to FE.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>The correlation between asbestiform fibers, lung cancer, pleural\nmesothelioma, and other lung diseases is already well established as the\npathophisiological pathophysiological respiratory mechanisms involved by inhalation of\nFluoro-edenite (FE). The latter is represented by cell proliferation and inducing the\nrelease of growth factors, cytokines, and reactive oxygen and nitrite species, with DNA\ndamage that causes chronic inflammation and carcinogenesis. MacroH2A.1, and histone\nvariant, seems to play a role in sensing the metabolic state of the cell and linking it with\nchromatin. Physiologically, MacroH2A.1 is expressed at low levels in stem cells and it\nbecame upregulated during differentiation, preventing reprogramming of induced\npluripotent stem cells and after nuclear transfer. In particular, MacroH2A.1 has been\nshown to explicate a potent antitumor mechanism in vivo as it results upregulated in\nsenescent cells determining a permanent growth-arrest.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Evaluate the possible role of the histone variant in the organism in response\nto deep insight understanding the mechanisms of toxicity and the cellular response to\nFE.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Lung and lymph nodes of exposed sheep were selected. Samples were\nprocessed for histological and immunihistochemical immunohistochemical evaluations.\nDensitometric, morphometric, and statistical analysis analyses were conducted.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Tissue sections of FE exposed sheep demonstrated overexpression of\nMacroH2A.1 vs unexposed samples. The data suggest an involvement of these this\nmolecule in the cellular response triggered by FE directed exposure.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this contest, MacroH2A.1 overexpression supports its function as an\nepigenetic stabilizer that helps to establish and maintain differentiated states.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1566524020666200220130023","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T15:23:14Z","timestamp":1582212194000},"page":"653-660","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An In vivo Immunohistochemical Study on MacroH2A.1 in Lung and Lymph-Node Tissues Exposed to an Asbestiform Fiber"],"prefix":"10.2174","volume":"20","author":[{"given":"Carla","family":"Loreto","sequence":"first","affiliation":[{"name":"Department of Bio-Medical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Human Anatomy, Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Caltabiano","sequence":"additional","affiliation":[{"name":"Anatomic Pathology, Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-8798","authenticated-orcid":true,"given":"Caterina","family":"Ledda","sequence":"additional","affiliation":[{"name":"Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Hagnas","sequence":"additional","affiliation":[{"name":"Rovaniemi Health Centre, Rovaniemi, Finland; 6Center for Life Course Health Research, University of Oulu, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Filetti","sequence":"additional","affiliation":[{"name":"Department of Bio-Medical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venerando","family":"Rapisarda","sequence":"additional","affiliation":[{"name":"Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/179590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/179590\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/179590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T10:52:39Z","timestamp":1610448759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/179590\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12,29]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1566524020666200220130023","relation":{},"ISSN":["1566-5240"],"issn-type":[{"type":"print","value":"1566-5240"}],"subject":[],"published":{"date-parts":[[2020,12,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}