{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:42:28Z","timestamp":1793716948298,"version":"4.6.1"},"reference-count":22,"publisher":"Bentham Science Publishers Ltd.","issue":"9","funder":[{"DOI":"10.13039\/501100011501","name":"Qinghai Provincial Science and Technology Department Applied Basic Research Project","doi-asserted-by":"publisher","award":["2019-ZJ-7094"],"award-info":[{"award-number":["2019-ZJ-7094"]}],"id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:sec>\n<jats:title>Aims:<\/jats:title>\n<jats:p>To investigate the role of Slit2 and Robo1 during the vascular disease\nof Polymyositis (PM) \/ dermatomyositis (DM).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background :<\/jats:title>\n<jats:p> PM and DM are nonsuppurative inflammatory myopathies that mainly\ninvade the skeletal muscles.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study attempted to explore the specific mechanism of Slit2\/Robo1\nsignaling pathway proteins during the vascular disease of PM\/DM.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The mRNA expressions of Slit2 and Robo1 in the muscle tissue were\ndetected by RT-qPCR between newly-diagnosed PM\/DM patients and healthy controls.\nThe number of Slit2 and Robo1 positive cells in the serial sections of muscle paraffin\ntissues was measured by immunohistochemistry in 10 patients with PM, 10 patients with\nDM and 20 healthy controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> The study results revealed that the mRNA expressions of Slit2 and Robo1 in\nmuscle tissue in the PM and DM groups were higher than that in the control group\n(P&lt;0.05). The positive expression rates of Slit2 and Robo1 in muscle tissue in the PM\nand DM groups were 80.0%, 80.0%, 70.0% and 70.0%, respectively. The difference was\nstatistically significant (P&lt;0.001), when compared to the control group (the positive\nexpression rates were 0% and 10%, respectively).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The activation of the Slit2\/Robo1 signaling pathway is an important\nmechanism leading to the development of PM\/DM.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1566524020666200326102837","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T11:48:37Z","timestamp":1585223317000},"page":"717-722","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Study Based on the Correlation Between Slit2\/Robo1 Signaling Pathway Proteins and Polymyositis\/Dermatomyositis"],"prefix":"10.2174","volume":"20","author":[{"given":"Ke-Xia","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Rheumatism and Immunology, Affiliated Hospital of Qinghai University, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunology, The People\u2019s Hospital of SND, Suzhou 215219, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Shuang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunology, The Second Hospital of Hebei University, Shijiazhuang 050000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Technology, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunology, Affiliated Hospital of Qinghai University, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunology, Affiliated Hospital of Qinghai University, Xining 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1177\/1203475416665601","volume":"21","author":"Qiang J.K.","year":"2017","unstructured":"Qiang J.K.; Kim W.B.; Baibergenova A.; Alhusayen R.; Risk of Malignancy in Dermatomyositis and Polymyositis. 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