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The multiplex bead immunoassay technique was\nused to measure the levels of HMGB1 and IL-8, IL-6, G-CSF, MCP-3, VEGF, sVEGFR-\n1, sVEFGR-2, TNF-\u03b1, PDGF, and IL-10 in aqueous. The data of Patients\u2019 demographics\nand preoperative intraocular pressure (IOP) were also collected for detailed analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The APAG group showed significantly elevated concentrations of HMGB1, IL-\n8, IL-6, G-CSF, VEGF, sVEGFR-1, and TNF-\u03b1 than those in the ARC group. Aqueous\nHMGB1 level correlated significantly with IOP, IL-8, IL-6, G-CSF and sVEGFR-1 levels\nbut not with age, TNF-\u03b1, or VEGF levels.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>The aqueous level of HMGB1 is elevated in APAG and associated with\naqueous level of inflammation-related cytokines, suggesting an association between\nelevated levels of HMGB1, APAC and certain inflammatory modulators which, of course,\nshould lead to further investigations in order to demonstrate the cause and effect.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1566524020666200413113107","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T18:53:31Z","timestamp":1586804011000},"page":"237-245","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of High-Mobility Group Box-1 with Inflammationrelated Cytokines in the Aqueous Humor with Acute Primary Angle-Closure Eyes"],"prefix":"10.2174","volume":"21","author":[{"given":"Wenjing","family":"He","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenya","family":"Yan","sequence":"additional","affiliation":[{"name":"GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, Guangzhou 511436,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaolan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siming","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Guangxi Medical University, Nanning 530021,China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"829","volume":"76","author":"Pokhrel P.K.","year":"2007","unstructured":"Pokhrel P.K.; Loftus S.A.; Ocular emergencies. 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