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Currently, the treatment is limited, therefore, there is an urgent need to determine the underline mechanism and develop a new treatment. It is well-known that normal bone remodeling relies on the balance between osteoclast-mediated bone resorption and - mediated bone formation. Various factors can destroy the balance, including the dysfunction of the immune system. In this review, we summarized the relevant research in the alcoholic osteopenia with a focus on the abnormal osteoimmunology signals. We provided a new theoretical basis for the prevention and treatment of the alcoholic bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We searched PubMed for publications from 1 January 1980 to 1 February 2020 to identify relevant and recent literature, summarizing evaluation and the prospect of alcoholic osteopenia. Detailed search terms were \u2018alcohol\u2019, \u2018alcoholic osteoporosis\u2019, \u2018alcoholic osteopenia\u2019 \u2018immune\u2019, \u2018osteoimmunology\u2019, \u2018bone remodeling\u2019, \u2018osteoporosis treatment\u2019 and \u2018osteoporosis therapy\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A total of 135 papers are included in the review. About 60 papers described the mechanisms of alcohol involved in bone remodeling. Some papers were focused on the pathogenesis of alcohol on bone through osteoimmune mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>There is a complex network of signals between alcohol and bone remodeling and intercellular communication of osteoimmune may be a potential mechanism for alcoholic bone. Studying the osteoimmune mechanism is critical for drug development specific to the alcoholic bone disorder.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1567201816666190514101303","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T07:43:07Z","timestamp":1557819787000},"page":"1815-1828","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Alcoholism and Osteoimmunology"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-6633","authenticated-orcid":true,"given":"Xiuwen","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-1420","authenticated-orcid":true,"given":"Lingyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-7664","authenticated-orcid":true,"given":"Xijie","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"244","volume":"35","author":"Poznyak V.","year":"2013","unstructured":"Poznyak V.; Fleischmann A.; Rekve D.; Rylett M.; Rehm J.; Gmel G.; The world health organization\u2019s global monitoring system on alcohol and health. 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Epid\u00e9miologie de l\u2019Ost\u00e9oporose. Am J Epidemiol 2000,151(8),773-780","journal-title":"Am J Epidemiol"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000147193","volume":"142","author":"Hern\u00e1ndez E.R.","year":"1991","unstructured":"Hern\u00e1ndez E.R.; Revilla M.; Rico H.; Total body bone mineral and pelvis bone mineral content as parameters of bone mass in men. A dual-energy X-ray absorptiometry study. Acta Anat (Basel) 1991,142(3),227-230","journal-title":"Acta Anat (Basel)"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3945\/ajcn.2008.26765","volume":"89","author":"Tucker K.L.","year":"2009","unstructured":"Tucker K.L.; Jugdaohsingh R.; Powell J.J.; Qiao N.; Hannan M.T.; Sripanyakorn S.; Cupples L.A.; Kiel D.P.; Effects of beer, wine and liquor intakes on bone mineral density in older men and women. 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