{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:59:01Z","timestamp":1776106741926,"version":"3.50.1"},"reference-count":39,"publisher":"Bentham Science Publishers Ltd.","issue":"7","funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Govt. of India","doi-asserted-by":"publisher","award":["6242- P74\/RGCB\/PMD\/DBT\/DP-MN\/2015"],"award-info":[{"award-number":["6242- P74\/RGCB\/PMD\/DBT\/DP-MN\/2015"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2019,10,3]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Prolonged chemodrug delivery to the tumor site is a prerequisite to maintaining\nits localised therapeutic concentrations for effective treatment of malignant solid tumors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The current study aims to develop implantable polymeric depots through conventional electrospinning\nfor sustained drug delivery, specifically to the peritoneum.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Non-woven electrospun mats were fabricated by simple electrospinning of Polydioxanone\nsolution loaded with the chemodrug, Paclitaxel. The implants were subjected to the analysis of morphology,\nmechanical properties, degradation and drug release in phosphate buffer and patient-derived\nperitoneal drain fluid samples. In vivo studies were conducted by surgical knotting of these implants to\nthe peritoneal wall of healthy mice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Non-woven electrospun mats with a thickness of 0.65\u00b10.07 mm, weighing ~ 20 mg were fabricated\nby electrospinning 15 w\/v% polymer loaded with 10 w\/w% drug. These implants possessing good\nmechanical integrity showed a drug entrapment efficiency of 87.82\u00b12.54 %. In vitro drug release studies\nin phosphate buffer showed a sustained profile for ~4 weeks with a burst of 10 % of total drug content,\nwhereas this amounted to &gt;60% in patient samples. Mice implanted with these depots remained healthy\nduring the study period. The biphasic drug release profile obtained in vivo showed a slow trend, with\nperitoneal lavage and tissues retaining good drug concentrations for a sustained period.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The results indicate that non-woven electrospun mats developed from biodegradable\nPolydioxanone polymer can serve as ideal candidates for easily implantable drug depots to address the\nchallenges of peritoneal metastasis in ovarian cancer.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201816666190816102949","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T09:26:13Z","timestamp":1565947573000},"page":"654-662","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nanofibrous Polydioxanone Depots for Prolonged Intraperitoneal Paclitaxel Delivery"],"prefix":"10.2174","volume":"16","author":[{"given":"Smrithi","family":"Padmakumar","sequence":"first","affiliation":[{"name":"Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala-682041, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthy","family":"Menon","sequence":"additional","affiliation":[{"name":"Centre for Nanosciences & Molecular Medicine, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala-682041, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"209","volume":"26","author":"Fung L.K.","year":"1997","unstructured":"Fung L.K.; Saltzman W.M.;  Polymeric Implants for Cancer Chemotherapy 1997,26,209-230","journal-title":"Polymeric Implants for Cancer Chemotherapy"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1023\/A:1025785505977","volume":"20","author":"Jang S.H.","year":"2003","unstructured":"Jang S.H.; Wientjes M.G.; Lu D.; Au J.L.; Drug delivery and transport to solid tumors. 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