{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:12:55Z","timestamp":1761808375283,"version":"3.37.3"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"2","funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["2560A10301031"],"award-info":[{"award-number":["2560A10301031"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012309","name":"Royal Golden Jubilee","doi-asserted-by":"publisher","award":["PHD\/0218\/2557"],"award-info":[{"award-number":["PHD\/0218\/2557"]}],"id":[{"id":"10.13039\/501100012309","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2021,2,26]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Oral mucositis, one of the most common complications of 5-Fluorouracil\n(5-FU) treatment, leads to several problems, including pain, diarrhea and malnutrition, and reduces\nthe quality of life and subsequent treatments. Melatonin, a neurohormone with anti-inflammatory\nand antioxidant activities, was encapsulated in niosomes and embedded in a mucoadhesive gel formulation\nas a Melatonin Niosome Gel (MNG) to perform oral mucositis treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aimed to investigate the effectiveness of MNG for the treatment of 5-FU-induced\noral mucositis in mice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> Oral mucositis was induced in ICR mice by 5-FU and randomly assigned to receive daily\napplications of the topical oral MNG, a fluocinolone acetonide gel, a blank niosome gel, or no\ntreatment for 5 days in comparison with a normal group. Average body weights, food consumption,\nand behaviors of the mice as well as microscopic histopathology, Fourier-Transform Infrared\nSpectroscopy (FTIR) analysis, proinflammatory cytokine levels, and oxidative stress markers of\nthe tongues were monitored and collected after sacrifice.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> In comparison to the normal group, the average body weights of the 5-FU-MNG mice did\nnot deviate from that of the normal group, nor was there a significant difference in the time to sleep\nor licking (<jats:italic>p<\/jats:italic>&gt;0.05 for both parameters). In addition, the mice treated with MNG and fluocinolone\nacetonide did not show significantly different histopathological, FTIR, interleukin-1\u03b2 or malondialdehyde\n(MDA) results in the tongues used as the oral tissue samples.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Topical MNG potentially inhibits inflammation and lipid oxidative stress in 5-FU-induced\noral mucositis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201817666200525151848","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T12:59:41Z","timestamp":1590411581000},"page":"199-211","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Topical Melatonin Niosome Gel for the Treatment of 5-FU-Induced Oral Mucositis in Mice"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2001-1992","authenticated-orcid":true,"given":"Prangtip","family":"Uthaiwat","sequence":"first","affiliation":[{"name":"Graduate School, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-4144","authenticated-orcid":true,"given":"Jureerut","family":"Daduang","sequence":"additional","affiliation":[{"name":"Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aroonsri","family":"Priprem","sequence":"additional","affiliation":[{"name":"Melatonin Research Group, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chatri","family":"Settasatian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirinart","family":"Chio-Srichan","sequence":"additional","affiliation":[{"name":"Synchrotron Light Research Institute (Public Organization), Nakhon Ratchasima, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"National Synchrotron Radiation Research Center, Hsinchu, Taiwan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramote","family":"Mahakunakorn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patcharee","family":"Boonsiri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/182272","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/182272\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/182272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T13:45:49Z","timestamp":1614692749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/182272\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,26]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,26]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201817666200525151848","relation":{},"ISSN":["1567-2018"],"issn-type":[{"type":"print","value":"1567-2018"}],"subject":[],"published":{"date-parts":[[2021,2,26]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}