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The\nmajor problem in the topical treatment of psoriasis is drug localization through the psoriasis lesions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> In this study, silibinin-loaded polymeric micelles prepared and characterized for drug loading\nand release and <jats:italic>ex vivo<\/jats:italic> permeation through psoriatic and normal mice skin. The optimized batch was\nused for the treatment of psoriasis lesions in the mice model.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The optimized batch demonstrated mean particle size 18.3 \u00b1 2.1 nm, entrapment efficiency\n75.8 \u00b1 5.8%, and prolonged silibinin release. % Silibinin permeated through psoriatic skin after 48\ntreated by polymeric micelle and aqueous control was 80.35, and 92.6, respectively. Polymeric micelles\nincreased silibinin localization in the psoriatic skin in comparison with control. In psoriatic skin after 7-\n10 days treatment by silibinin- loaded polymeric micelle, there was no evidence of psoriasis and the\nhistological evaluation showed no sign of psoriasis. Silibinin-loaded polymeric micelles reduced Psoriasis\narea index by more than 78% after 14 days.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> It seems that polymeric micelles increased the effectiveness of silibinin by drug localization\ninto the psoriatic plaque. Topical STAT- 3inhibitors can be introduced as a new strategy in psoriasis\ntreatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201817666200722141807","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T06:29:58Z","timestamp":1595572198000},"page":"787-798","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Delivery and Anti-Psoriatic Effect of Silibinin-Loaded Polymeric Micelles: An Experimental Study in the Psoriatic Skin Model"],"prefix":"10.2174","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-1150","authenticated-orcid":true,"given":"Fateme","family":"Chavoshy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad Sharif Makhmal","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohammad","family":"Tamaddon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Nanotechnology, Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Houssin","family":"Anbardar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/exd.13403","volume":"27","author":"Jin S.P.","year":"2018","unstructured":"Jin S.P.; Koh S.J.; Yu D.A.; Kim M.W.; Yun H.T.; Lee D.H.; Yoon H.S.; Cho S.; Park H.S.; Imiquimod-applied interleukin-10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state. 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