{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:29:40Z","timestamp":1780489780534,"version":"3.54.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:sec>\n<jats:title> Aim:<\/jats:title>\n<jats:p>To design D-Mannose conjugated 5-Fluorouracil (5-FU) loaded Jackfruit Seed\nStarch Nanoparticles (JFSSNPs) for site-specific delivery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Liver cancer is the third leading cause of death in the world and the fifth most often\ndiagnosed cancer. It is a major global threat to public health. Treatment of liver cancer with conventional\nmethod bears several side effects, thus to undertake these side effects as a formulation challenge,\nit is necessary to develop novel target-specific drug delivery system for the effective and better\nlocalization of drug into the proximity of target with restricting the movement of the drug in normal\ntissues.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To optimize and characterize the developed D-Mannose conjugated 5-Fluorouracil (5-\nFU) loaded Jackfruit Seed Starch Nanoparticles (JFSSNPs) for effective treatment of liver cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and methods:<\/jats:title>\n<jats:p>5-FU loaded JFSSNPs were prepared and optimized formulations having\nhigher encapsulation efficiency were conjugated with D-Mannose. These formulations were characterized\nfor size, morphology, zeta potential, X-Ray Diffraction, and Differential Scanning\nCalorimetry. The potential of NPs was studied using in vitro cytotoxicity assay, in vivo kinetic\nstudies, and bio-distribution studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results and Discussion:<\/jats:title>\n<jats:p>5-Fluorouracil loaded NPs had a particle size between 336 to 802 nm with\ndrug entrapment efficiency between 64.2 to 82.3%. In XRD analysis, 5-FU peak was diminished in\nthe diffractogram, which could be attributed to the successful incorporation of the drug in amorphous\nform. DSC study suggests there was no physical interaction between 5-FU and Polymer. NPs\nshowed sustained in vitro 5-FU release up to 2 hours. In vivo, mannose conjugated NPs prolonged\nthe plasma level of 5-FU and assisted in the selective accumulation of 5-FU in the liver (vs. other\norgans spleen, kidney, lungs, and heart) compared to unconjugated one and plain drug.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In vivo, bio-distribution, and plasma profile studies resulted in a significantly higher\nconcentration of 5-Fluorouracil liver, suggesting that these carriers are efficient, viable, and targeted\ncarrier of 5-FU treatment of liver cancer.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201817666200903171124","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T11:38:55Z","timestamp":1599219535000},"page":"369-380","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mannose Conjugated Starch Nanoparticles for Preferential Targeting of Liver Cancer"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-9773","authenticated-orcid":true,"given":"Akhlesh Kumar","family":"Jain","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Sahu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-0267","authenticated-orcid":true,"given":"Keerti","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur- 495 009 (C.G.), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-3529","authenticated-orcid":true,"given":"Suresh","family":"Thareja","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda-151 001 Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/185553","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/185553\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/185553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:03:47Z","timestamp":1621343027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/185553\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5,17]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201817666200903171124","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,17]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}