{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T21:31:35Z","timestamp":1781040695992,"version":"3.54.1"},"reference-count":40,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2021,8,6]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Madhuca longifolia has been used for the treatment of renal cancer. Therefore, the current study describes the protective effects of biofabricated silver nanoparticles (MLAgNPs) using Madhuca longifolia aqueous leaves extract against diethylnitrosamine (DEN) induced renal cell carcinoma (RCC) in rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> Animals were categorized into five groups and treated with doses of silver nanoparticles for 16 weeks. Antineoplastic effect in renal cancer was dose dependent to control the macroscopical variations when compared to DEN induced group. Significant changes were observed in biochemical parameters and dose graded improvement in the level of antioxidants parameters were accountable for its protective nature.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Result:<\/jats:title>\n<jats:p>Silver nanoparticles in dose dependent manner was effective to modify the raised levels of\npro-inflammatory cytokines and inflammatory mediators during renal cancer. Alteration in renal\nhistopathology were also detected in the silver nanoparticles treated group, which show its safety\nconcern. Biofabricated silver nanoparticles (MLAgNPs) using Madhuca longifolia can convey significant\nchemo-protective effect against renal cancer by suppressing the IL-6, TNF-\u03b1 and IL-1\u03b2 by\nnuclear factor-kappa B (NF-\u03baB) pathway.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our outcomes implicates that biofabricated MLAgNPs exhibited a chemoprotective potential in the prevention\nand intervention of RCC.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201817666200910154301","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T11:52:36Z","timestamp":1599825156000},"page":"634-644","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Madhuca longifolia Embedded Silver Nanoparticles Attenuate Diethylnitrosamine (DEN)-Induced Renal Cancer via Regulating Oxidative Stress"],"prefix":"10.2174","volume":"18","author":[{"given":"Deepika","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad-211007, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad-211007, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad-211007, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad-211007, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.semcancer.2012.06.003","volume":"23","author":"Maher E.R.","year":"2013","unstructured":"Maher E.R.; Genomics and epigenomics of renal cell carcinoma. 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