{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:05:28Z","timestamp":1790953528149,"version":"4.1.0"},"reference-count":38,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2021,5,28]]},"abstract":"<jats:sec><jats:title\/><jats:p>Severe Acute Respiratory Syndrome Coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until today, the best solution for the moment remains prevention (Social distancing, hand disinfection, use of masks, partial or total sanitary containment, etc.); there is also the emergence of drug treatment (research and development, clinical trials, use on patients). Recent reviews emphasized the role of membrane lipids in the infectivity mechanism of SARS-COV-2. Cholesterol-rich parts of cell membranes serve as docking places of host cells for the viruses. Coronavirus 2 is a member of a virus family with lipid envelope that fuses with host cell through endocytosis, internalizing its components in the cell. In vitro cell models have shown that depletion of cholesterol by cyclodextrin, and particularly methyl beta cyclodextrin disturb the host cell membrane lipid composition this way, reducing the attachment of the virus to the protein receptors. This review aims to summarize the state of the art of research concerning the use of cyclodextrin or its complexes as a potential treatment against this new virus and update work already published.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1567201817666200917124241","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T11:58:30Z","timestamp":1600343910000},"page":"382-386","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Use of Cyclodextrin or its Complexes as a Potential Treatment Against the 2019 Novel Coronavirus: A Mini-Review"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-7831","authenticated-orcid":true,"given":"Sofiane","family":"Fatmi","sequence":"first","affiliation":[{"name":"Department of Processes Engineering, Faculty of Technology, Technology Pharmaceutical Laboratory, Universit\u00e9 de Bejaia, 06000, Bejaia, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-1591","authenticated-orcid":true,"given":"Lamia","family":"Taouzinet","sequence":"additional","affiliation":[{"name":"Department of Processes Engineering, Faculty of Technology, Technology Pharmaceutical Laboratory, Universit\u00e9 de Bejaia, 06000, Bejaia, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-7743","authenticated-orcid":true,"given":"Mohamed","family":"Skiba","sequence":"additional","affiliation":[{"name":"Technology Pharmaceutical and Bio Pharmaceutics Laboratory, UFR Medicine and Pharmacy, Rouen University, 22 Blvd. Gambetta, 76183, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-0670","authenticated-orcid":true,"given":"Mokrane","family":"Iguer-Ouada","sequence":"additional","affiliation":[{"name":"Faculty of Nature and Life Sciences, Associated Laboratory in Marine Ecosystems and Aquaculture, Universit\u00e9 de Bejaia, 06000, Bejaia, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"Zhu N.","year":"2020","unstructured":"Zhu N.; Zhang D.; Wang W.; Li X.; Yang B.; Song J.; Zhao X.; Huang B.; Shi W.; Lu R.; Niu P.; Zhan F.; Ma X.; Wang D.; Xu W.; Wu G.; Gao G.F.; Tan W.; China novel coronavirus investigating and research team. A novel coronavirus from patients with pneumonia in China 2019. N Engl J Med 2020,382(8),727-733","journal-title":"N Engl J Med"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/d41753-020-00016-0","volume":"19","author":"Guangdi L.","year":"2019","unstructured":"Guangdi L.; Erik D.C.; Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov 2019,19(3),149-150","journal-title":"Nat Rev Drug Discov"},{"key":"ref=3","year":"2020","unstructured":"Coronavirus disease 2019 (COVID-19). Situation report 115. World Health Organization, May 14 https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus- 2019\/situation-reports\/2020","journal-title":"World Health Organization, May 14"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1001\/jama.2020.4783","volume":"323","author":"Shen C.","year":"2020","unstructured":"Shen C.; Wang Z.; Zhao F.; Yang Y.; Li J.; Yuan J.; Wang F.; Li D.; Yang M.; Xing L.; Wei J.; Xiao H.; Yang Y.; Qu J.; Qing L.; Chen L.; Xu Z.; Peng L.; Li Y.; Zheng H.; Chen F.; Huang K.; Jiang Y.; Liu D.; Zhang Z.; Liu Y.; Liu L.; Treatment of 5 critically Ill patients with COVID-19 with convalescent plasma. JAMA 2020,323,1582-1589","journal-title":"JAMA"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.18433\/jpps31002","volume":"23","author":"Md Insiat I.R.","year":"2020","unstructured":"Md Insiat I.R.; Current drugs with potential for treatment of COVID-19: a literature review: drugs for the treatment process of COVID-19. J Pharm Pharm Sci 2020,23,58-64","journal-title":"J Pharm Pharm Sci"},{"key":"ref=6","first-page":"1","volume":"30","author":"Howard J.","year":"2020","unstructured":"Howard J.; Huang A.; Li Z.; Tufekci Z.; Zdimal V.; van der Westhuizen H.; von Delft A.; Price A.; Fridman L.; Tang L.; Tang V.; Watson G.L.; Bax C.E.; Shaikh R.; Questier F.; Hernandez D.; Chu L.F.; Ramirez C.M.; Rimoin A.W.; Face masks against COVID-19: an evidence review. PNAS 2020,30,1-9","journal-title":"PNAS"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.2139\/ssrn.3549276","volume":"212","author":"Dalton C.","year":"2020","unstructured":"Dalton C.; Corbett S.; Katelaris A.; Pre-emptive low cost social distancing and enhanced hygiene implemented before local COVID-19 transmission could decrease the number and severity of cases. Med J Aust 2020,212(10),443-446","journal-title":"Med J Aust"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jama.1991.03460200084041","volume":"99","author":"Mark D.","year":"2020","unstructured":"Mark D.; Joseph M. Berning; Carole C.; Trish S.; Chad H.; Kent J.; Adams, Joe W.; Mike C.; COVID-19: beyond washing your hands and social distancing. Int J Sci Engr Investigat 2020,99,1-4","journal-title":"Int J Sci Engr Investigat"},{"key":"ref=9","first-page":"161","volume":"91","author":"Baglivo M.","year":"2020","unstructured":"Baglivo M.; Baronio M.; Natalini G.; Beccari T.; Chiurazzi P.; Fulcheri E.; Petralia PP.; Michelini S.; Fiorentini G.; Miggiano GA.; Morresi A.; Tonini G.; Bertelli M.; Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity? Acta Biomed 2020,91,161-164","journal-title":"Acta Biomed"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.tim.2011.03.007","volume":"19","author":"Heaton N.S.","year":"2011","unstructured":"Heaton N.S.; Randall G.; Multifaceted roles for lipids in viral infection. Trends Microbiol 2011,19(7),368-375","journal-title":"Trends Microbiol"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s13567-020-0739-7","volume":"51","author":"Wei X.","year":"2020","unstructured":"Wei X.; She G.; Wu T.; Xue C.; Cao Y.; PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-\/lysosome pathway. Vet Res (Faisalabad) 2020,51(1),10","journal-title":"Vet Res (Faisalabad)"},{"key":"ref=12","first-page":"113","volume":"39","author":"Khellouf A.","year":"2018","unstructured":"Khellouf A.; Benhenia K.; Fatami S.; Iguer-Ouada M.; The complementary effect of cholesterol and vitamin E preloaded in cyclodextrins on frozen bovine semen: motility parameters, membrane integrity and lipid peroxidation. Cryo Lett 2018,39(2),113-120","journal-title":"Cryo Lett"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.smallrumres.2016.06.009","volume":"141","author":"Benhenia K.","year":"2016","unstructured":"Benhenia K.; Lamara A.; Fatmi S.; Iguer-Ouada M.; Effect of cyclodextrins, cholesterol and vitamin E and their complexation on cryopreserved epididymal ram semen. Small Rumin Res 2016,141,29-35","journal-title":"Small Rumin Res"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-1-4939-1752-5_8","volume":"1232","author":"Mahammad S.","year":"2015","unstructured":"Mahammad S.; Parmryd I.; Cholesterol depletion using methyl-\u03b2- cyclodextrin. Methods Mol Biol 2015,1232,91-102","journal-title":"Methods Mol Biol"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1515\/aut-2011-110401","volume":"11","author":"Bhaskara-Amrit U.R.","year":"2011","unstructured":"Bhaskara-Amrit U.R.; Agrawal P.B.; Warmoeskerken M.C.G.; Applications of B -cyclodextrins in textiles. AUTEX Res J 2011,11,94-101","journal-title":"AUTEX Res J"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0032-9592(03)00258-9","volume":"39","author":"Del-Valle E.M.M.","year":"2004","unstructured":"Del-Valle E.M.M.; Cyclodextrins and their uses: a review. Process Biochem 2004,39,1033-1046","journal-title":"Process Biochem"},{"key":"ref=17","first-page":"179","volume":"72","author":"Fatmi S.","year":"2015","unstructured":"Fatmi S.; Bournine L.; Iguer-Ouada M.; Lahiani-Skiba M.; Bouchal F.; Skiba M.; Amorphous solid dispersion studies of camptothecin-cyclodextrin inclusion complexes in PEG 6000. Acta Pol Pharm 2015,72(1),179-192","journal-title":"Acta Pol Pharm"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"198268","DOI":"10.1155\/2015\/198268","volume":"2015","author":"Gidwani B.","year":"2015","unstructured":"Gidwani B.; Vyas A.; A comprehensive review on cyclodextrin-based carriers for delivery of chemotherapeutic cytotoxic anticancer drugs. BioMed Res Int 2015,2015,198268","journal-title":"BioMed Res Int"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules22010001","volume":"22","author":"di Cagno M.P.","year":"2016","unstructured":"di Cagno M.P.; The potential of cyclodextrins as novel active pharmaceutical ingredients: a short overview. Molecules 2016,22(1),1-15","journal-title":"Molecules"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"e1002020","DOI":"10.1371\/journal.pcbi.1002020","volume":"7","author":"L\u00f3pez C.A.","year":"2011","unstructured":"L\u00f3pez C.A.; de Vries A.H.; Marrink S.J.; Molecular mechanism of cyclodextrin mediated cholesterol extraction. PLOS Comput Biol 2011,7(3),e1002020","journal-title":"PLOS Comput Biol"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.bbamem.2007.03.026","volume":"1768","author":"Zidovetzki R.","year":"2007","unstructured":"Zidovetzki R.; Levitan I.; Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim Biophys Acta 2007,1768(6),1311-1324","journal-title":"Biochim Biophys Acta"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"eaax9318","DOI":"10.1126\/sciadv.aax9318","volume":"6","author":"Jones S.T.","year":"2020","unstructured":"Jones S.T.; Cagno V.; Jane\u010dek M.; Ortiz D.; Gasilova N.; Piret J.; Gasbarri M.; Constant D.A.; Han Y.; Vukovi\u0107 L.; Kr\u00e1l P.; Kaiser L.; Huang S.; Constant S.; Kirkegaard K.; Boivin G.; Stellacci F.; Tapparel C.; Modified cyclodextrins as broad-spectrum antivirals. Sci Adv 2020,6(5),eaax9318","journal-title":"Sci Adv"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.freeradbiomed.2009.02.032","volume":"46","author":"Du W.","year":"2009","unstructured":"Du W.; Ayscough K.R.; Methyl \u03b2-cyclodextrin reduces accumulation of reactive oxygen species and cell death in yeast. Free Radic Biol Med 2009,46(11),1478-1487","journal-title":"Free Radic Biol Med"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3126\/nmj.v3i1.28256","volume":"3","author":"Shrestha S.","year":"2020","unstructured":"Shrestha S.; Statin drug therapy may increase covid-19 infection. Nepalese Medical J 2020,3,1","journal-title":"Nepalese Medical J"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"104752","DOI":"10.1016\/j.antiviral.2020.104752","volume":"176","author":"Jiang Y.","year":"2020","unstructured":"Jiang Y.; Liu S.; Shen S.; Guo H.; Huang H.; Wei W.; Methyl-\u03b2-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts. Antiviral Res 2020,176,104752","journal-title":"Antiviral Res"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"E1126","DOI":"10.3390\/jcm9041126","volume":"9","author":"Carrouel F.","year":"2020","unstructured":"Carrouel F.; Conte M.P.; Fisher J.; Gon\u00e7alves L.S.; Dussart C.; Llodra J.C.; Bourgeois D.; COVID-19: a recommendation to examine the effect of mouthrinses with \u03b2-cyclodextrin combined with citrox in preventing infection and progression. J Clin Med 2020,9(4),E1126","journal-title":"J Clin Med"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/jmv.25804","volume":"92","author":"Sun P.","year":"2020","unstructured":"Sun P.; Lu X.; Xu C.; Wang Y.; Sun W.; Xi J.; CD-sACE2 inclusion compounds: an effective treatment for coronavirus disease 2019 (COVID-19). J Med Virol 2020,92(10),1721-1723","journal-title":"J Med Virol"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s40520-020-01570-8","volume":"32","author":"Ilie P.C.","year":"2020","unstructured":"Ilie P.C.; Stefanescu S.; Smith L.; The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res 2020,32(7),1195-1198","journal-title":"Aging Clin Exp Res"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/apt.15752","volume":"51","author":"Panarese A.","year":"2020","unstructured":"Panarese A.; Shahini E.; Letter: covid-19, and vitamin D. Aliment Pharmacol Ther 2020,51(10),993-995","journal-title":"Aliment Pharmacol Ther"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3390\/pr8050549","volume":"8","author":"Meneguzzo F.","year":"2020","unstructured":"Meneguzzo F.; Ciriminna R.; Zabini F.; Pagliaro M.; Review of evidence available on hesperidin-rich products as potential tools against COVID-19 and hydrodynamic cavitation-based extraction as a method of increasing their production. Processes (Basel) 2020,8,549","journal-title":"Processes (Basel)"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2478\/bile-2020-0002","volume":"57","author":"Sawikowska A.","year":"2020","unstructured":"Sawikowska A.; Meta-analysis of flavonoids with antiviral potential against coronavirus. Biometrical Lett 2020,57(1),13-22","journal-title":"Biometrical Lett"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.37200\/IJPR\/V24I5\/PR201792","volume":"24","author":"Abdalkader S.L.","year":"2020","unstructured":"Abdalkader S.L.; Alia Essam M.A.; Majida G.; Computational study of oseltamivir, chloroquine, hydroxy chloroquine, ribavirin and kaletra against lysosomal protease Int J Psychosoc Rehabil 2020,24,1170-1176","journal-title":"Int J Psychosoc Rehabil"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"e40","DOI":"10.26633\/RPSP.2020.40","volume":"44","author":"Sandro G.","year":"2020","unstructured":"Sandro G.; Viveiros,R. and Wilson, C S. \u201cClinical trials on drug repositioning for COVID-19 treatment. Rev Panam Salud Publica 2020,44,e40","journal-title":"Rev Panam Salud Publica"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1023\/A:1023088423667","volume":"44","author":"Loftsson T.","year":"2002","unstructured":"Loftsson T.; Cyclodextrins and the biopharmaceutics classification system of drugs. J Inclusion Phenomena 2002,44,63-67","journal-title":"J Inclusion Phenomena"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1021\/js950534b","volume":"85","author":"Loftsson T.","year":"1996","unstructured":"Loftsson T.; Brewster M.E.; Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci 1996,85(10),1017-1025","journal-title":"J Pharm Sci"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.3390\/molecules23051161","volume":"23","author":"Saokham P.","year":"2018","unstructured":"Saokham P.; Muankaew C.; Jansook P.; Loftsson T.; Solubility of cyclodextrins and drug\/cyclodextrin complexes. Molecules 2018,23(5),1161-1176","journal-title":"Molecules"},{"key":"ref=37","first-page":"1","year":"2017","unstructured":"Cyclodextrins used as excipients, Committee for human medicinal products. Euro Med Agency 2017,1-16","journal-title":"Euro Med Agency"},{"key":"ref=38","first-page":"1","author":"Raymond C.R.","year":"2009","unstructured":"Raymond C.R.; Paul J.S.; Marian E.Q; Handbook of pharmaceutical excipients. Pharmaceut Press Am Pharmacists Associat 2009,1-855","journal-title":"Pharmaceut Press Am Pharmacists Associat"}],"container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/186001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/186001\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/186001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T01:27:59Z","timestamp":1723598879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/186001\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5,28]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201817666200917124241","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}