{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:45:00Z","timestamp":1772113500579,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M632628"],"award-info":[{"award-number":["2018M632628"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701838"],"award-info":[{"award-number":["81701838"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Chronic inflammation and lack of angiogenesis are the important pathological\nmechanisms in Deep Tissue Injury (DTI). Curcumin is a well-known anti-inflammatory and antioxidant\nagent. However, curcumin is unstable under acidic and alkaline conditions and can be\nrapidly metabolized and excreted in the bile, which shortens its bioactivity and efficacy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aimed to prepare curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles\n(CPNPs) and to elucidate the protective effects and underlying mechanisms of wound healing\nin DTI models.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>CPNPs were evaluated for particle size, biocompatibility, in vitro drug release and their\neffect on in vivo wound healing.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results :<\/jats:title>\n<jats:p> The results of in vivo wound closure analysis revealed that CPNP treatments significantly\nimproved wound contraction rates (p&lt;0.01) at a faster rate than the other three treatment groups.\nH&amp;E staining revealed that CPNP treatments resulted in complete epithelialization and thick granulation\ntissue formation. In contrast, control groups resulted in a lack of compact epithelialization\nand persistence of inflammatory cells within the wound sites. Quantitative real-time PCR analysis\nshowed that treatment with CPNPs suppressed IL-6 and TNF-\u03b1 mRNA expression, and up-regulated\nTGF-\u03b2, VEGF-A and IL-10 mRNA expression. Western blot analysis showed up-regulated protein\nexpression of TGF-\u03b2, VEGF-A and phosphorylated-STAT3.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our results showed that CPNPs enhanced wound healing in DTI models through modulation\nof the JAK2\/STAT3 signalling pathway and subsequent upregulation of pro-healing factors.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201818666201214125237","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T11:02:07Z","timestamp":1608030127000},"page":"1003-1013","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Healing Effects of Curcumin Nanoparticles in Deep Tissue Injury Mouse Model"],"prefix":"10.2174","volume":"18","author":[{"given":"Zirui","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Nursing, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangcong","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nursing, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"School of Nursing, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing, Qingdao University, Qingdao, Shibei District, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189117\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T13:21:51Z","timestamp":1639747311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189117\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201818666201214125237","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}