{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:22:56Z","timestamp":1789705376679,"version":"4.0.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p> The most common treatment for Primary Open-Angle Glaucoma (POAG)\nis the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve\npatient adherence by achieving prolonged therapeutic drug concentrations in ocular target tissues\nwhile limiting systemic exposure. The purpose of this study is to compare the efficacy and\nsafety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and Ocular Hypertension\n(OH).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>We include OH and POAG patients aged between 40 and 75 years-old. Both OH and\nPOAG patients had intraocular pressure (IOP) greater than 21 and \u226430 mmHg at 9:00 am without\nglaucoma medication and normal biomicroscopy. Five normal patients with IOP\u226414 mmHg constitute\nthe control group. A chitosan-based insert of bimatoprost was placed at the upper conjunctival\nfornix of the right eye. In the left eye, patients used one drop of LumiganTM daily at 10:00 pm.\nFor statistical analysis, a two-way analysis of variance (ANOVA), Student t-test, and paired t-test\nis used.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Sixteen POAG and 13 OH patients with a mean age of 61 years were assessed. In both\neyes, IOP reduction was similar during three weeks of follow-up (19.5\u00b12.2 mmHg and 16.9\u00b13.1\nmmHg), insert, and eye drop, respectively; P=0.165). The percentage of IOP reduction in the third\nweek was 30% for insert and 35% for eye drops (P=0.165). No intolerance or discomfort with the\ninsert was reported. Among the research participants, 58% preferred the use of the insert while\n25% preferred eye drops, and 17% reported no preference.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>Bimatoprost-loaded inserts showed similar efficacy to daily bimatoprost eye drops\nduring three weeks of follow up, without major side effects. This might suggest a possible change\nin the daily therapeutic regimen for the treatment of POAG and OH.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201818666210101112256","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T14:12:12Z","timestamp":1609683132000},"page":"1022-1026","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocular Hypertension Treatment - A Phase II Controlled Study"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-3009","authenticated-orcid":true,"given":"Francine","family":"Rubi\u00e3o","sequence":"first","affiliation":[{"name":"Medical School, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-8188","authenticated-orcid":true,"given":"Alan Cezar Faria","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Medical School, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8238-5095","authenticated-orcid":true,"given":"Jo\u00e3o Bernardo","family":"Sancio","sequence":"additional","affiliation":[{"name":"Medical School, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9867-8631","authenticated-orcid":true,"given":"B\u00e1rbara Silva","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Medical School, Universidade Federal de Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8099-2489","authenticated-orcid":true,"given":"Ju\u00e7ara Ribeiro","family":"Franca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2918-5718","authenticated-orcid":true,"given":"Jos\u00e9 Carlos","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-872X","authenticated-orcid":true,"given":"Anderson Jos\u00e9","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-6158","authenticated-orcid":true,"given":"Andr\u00e9 Augusto Gomes","family":"Faraco","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-6368","authenticated-orcid":true,"given":"Giselle","family":"Foureaux","sequence":"additional","affiliation":[{"name":"Department of Morphology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-9963","authenticated-orcid":true,"given":"Sebasti\u00e3o","family":"Cronemberger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189800\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T13:21:55Z","timestamp":1639747315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189800\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201818666210101112256","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Peer 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