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The IR and 1H NMR, were used to characterise the PLGA-b-PEG copolymer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Nanoprecipitation method was used to make PLGA-b-PEG NPs. To promote SVCT2-mediated transportation of ascorbic acid (Asc) into the brain, PLGA-b-PEG NPs of acceptable size, polydispersity, and drug loading were bound with ascorbic acid (PLGA-b-PEG-Asc). When compared to PLGA-b-mPEG NPs, the surface functionalization of NPs with ascorbic acid dramatically improved cellular uptake of NPs in SVCT2 expressing NIH\/3T3 cells. Radial Arm Maze Test, and Acetylcholinesterase (AChE) activity in scopolamine-induced amnetic rats were used to assess in vivo pharmacodynamic effectiveness.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Result:<\/jats:title>\n<jats:p>In vivo pharmacodynamic tests revealed that drug loaded PLGA-b-PEG-Asc NPs had much greater therapeutic and sustained activity than free drugs, and PLGA-b-mPEG NPs to the brain.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>As a consequence, the findings revealed that using ascorbic acid grafted PLGA-b-PEG NPs to deliver bioactives to the brain is a potential strategy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201819666220516093425","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T07:55:20Z","timestamp":1652774120000},"page":"961-977","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An In vivo Investigation of Ascorbic Acid Tethered Polymeric Nanoparticles\nfor Effectual Brain Transport of Rivastigmine"],"prefix":"10.2174","volume":"20","author":[{"given":"Kavita R.","family":"Gajbhiye","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Engineering and Technology, Dr. Hari Singh Gour University,\nSagar, MP, 470003 India"},{"name":"Poona College of Pharmacy, Bharati Vidyapeeth, Pune, 411038, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, School of Engineering and Technology, Dr. Hari Singh Gour University,\nSagar, MP, 470003 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"DeTure M.A.","year":"2019","unstructured":"DeTure M.A.; Dickson D.W.; The neuropathological diagnosis of Alzheimer\u2019s disease. 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