{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:37:00Z","timestamp":1787791020596,"version":"build-2784847793"},"reference-count":50,"publisher":"Bentham Science Publishers Ltd.","issue":"9","funder":[{"DOI":"10.13039\/501100010882","name":"Scientific Research Program of Tianjin Municipal Education Commission","doi-asserted-by":"publisher","award":["2017KJ130"],"award-info":[{"award-number":["2017KJ130"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Mesoporous silica nanoparticles (MSNs) are one of the most promising carriers for drug delivery. MSNs have been widely used in pharmaceutical research as drug carriers because\nof their large pore volume, high surface area, excellent biocompatibility, nontoxicity, ease to functionalize, and sustained release effects. MSNs have attracted much attention during drug delivery because of\ntheir special structure.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The present study aimed to synthesize mesoporous silica nanoparticles (MSNs), dendritic\nmesoporous silica nanoparticles (DMSN), and hollow mesoporous silica nanoparticles (HMSN) through\nfacile methods, and to compare the drug release properties of nano-porous silica with different pore\nstructures as a stroma for PUE drug.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>MSN, DMSN, and HMSN were characterized by SEM, TEM, FT-IR, nitrogen adsorptiondesorption isotherms, XRD, and zeta potential methods. Subsequently, puerarin (PUE) was used as the\nactive ingredient and loaded into the three mesoporous materials, respectively. And, the drug delivery\nbehavior was measured in PBS solution with different pH values. The sustained-release properties of\nMSN, DMSN, and HMSN loaded with PUE were investigated. Finally, the biocompatibility and stability of MSN, DMSN, and HMSN were studied by MTT assay and hemolysis assay.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Our results showed that MSN, DMSN, and HMSN were successfully synthesized and the three\ntypes of mesoporous silica nanoparticles had higher drug loading and encapsulation efficiency. According to the first-order release equation curve and Higuchi equation parameters, the results showed that the\nPUE-loaded MSN, DMSN, and HMSN exhibited sustained-release properties. Finally, MTT and hemolysis methods displayed that MSN, DMSN, and HMSN had good biocompatibility and stability.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this study, MSN, DMSN, and HMSN were successfully synthesized, and to compare the\ndrug release properties of nano-porous silica with different pore structures as a stroma for PUE drug, we\nprovided a theoretical and practical basis for the application of PUE.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201819666220616121602","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T09:37:39Z","timestamp":1655458659000},"page":"1337-1350","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Facile Synthesis of Three Types of Mesoporous Silica Microspheres as\nDrug Delivery Carriers and their Sustained-Release Properties"],"prefix":"10.2174","volume":"20","author":[{"given":"Yameng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin\n301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin\n301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin\n301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin\n301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.3390\/jfb9010013","volume":"9","author":"Larra&#xF1;eta E.","year":"2018","unstructured":"Larra&#xF1;eta E.; Stewart S.; Ervine M.; Al-Kasasbeh R.; Donnelly R.F.; Hydrogels for hydrophobic drug delivery. 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