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The drug candidates which are not stable\nat alkaline pH and soluble in acidic medium were selected to increase their therapeutic effectiveness\nthrough gastro retentive drug delivery systems (GRDDS). This article discusses various factors which\nalter the gastro retention time (GRT) of the gastro retentive drug delivery system in the stomach and\nintestine (duodenum). It emphasizes on the novel approaches made for the delivery and release of drugs\nwith the use of magnetic systems, floating (low-density) systems, super porous hydrogels, raft systems,\nmucoadhesive systems, high-density systems and expandable systems. Along with the applications, the\nkey aspects of in vivo, in vitro &amp; clinical studies in different approaches to GRDDS have been addressed.\nIn addition, future perspectives have been summarized to reduce gastric transit time in fasting\nand fed conditions.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201819666220819200236","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:50:04Z","timestamp":1660992604000},"page":"708-729","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["An Insight on Novel Approaches &amp; Perspectives for Gastro-Retentive\nDrug Delivery Systems"],"prefix":"10.2174","volume":"20","author":[{"given":"Sonia","family":"Dhiman","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nincy","family":"Philip","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":true,"given":"Thakur","family":"Gurjeet Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchu","family":"Babbar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Garg","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanshika","family":"Diwan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ijpharm.2016.05.016","volume":"510","author":"Lopes C.M.","year":"2016","unstructured":"Lopes C.M.; Bettencourt C.; Rossi A.; Buttini F.; Barata P.; Overview on gastroretentive drug delivery systems for improving drug bioavailability. 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