{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:25:23Z","timestamp":1793744723206,"version":"4.6.1"},"reference-count":148,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>The osteoarthritis (OA) causes economic, social, and health difficulties to the patients. Approximately 10% to 15% of all persons above the age of 60 have some degree of OA. OA is more common in women than in males. Diagnosed OA prevalence varies widely among EU member states, from 2.8% in Romania to 18.3% in Hungary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Introduction:<\/jats:title><jats:p>Osteoarthritis (OA) is a slow-progressing, non-inflammatory disorder. This disorder ultimately destroys articular cartilage and other joint components. The main symptoms are stiffness, pain, loss of flexibility, swelling, and bone spurs. Many risk factors, both modifiable and non-modifiable, have been associated with osteoarthritis (OA), including obesity and lack of exercise, genetic susceptibility, bone density, work-related damage, and trauma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p>Hydrogels, micro and nano-sized particles, and novel topical gels are among the most common examples. Hydrogels are cross-linked polymers with 3-D architecture that can hold water and expand like living tissue. The Micro-carriers, and nano-based drug delivery systems provide several advantages and may demonstrate prolonged release, controlled release, and higher joint half-life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result:<\/jats:title><jats:p>OA-induced male Lewis rats were injected with celecoxib-loaded PEA microspheres to assess in vivo biocompatibility and degradation. According to the findings of this research, PEA microspheres loaded with celecoxib may be employed as safe delivery of drug with self-regulating behavior for the pain treatment related to knee osteoarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The concept of novel drug delivery systems has shown tangible benefits as a new avenue for precise, safe, and high-quality drug delivery for OA treatment. Currently, herbal drugs are also used in osteoarthritis treatment due to their potency and fewer side effects in contrast to synthetic drugs. The herbo-synthetic approach is a new concept for the delivery of both herbal and synthetic drugs together to exploit their individual beneficial effects while reducing undesirable side effects.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1567201819666220901092832","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T12:45:26Z","timestamp":1662209126000},"page":"841-856","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Novel Formulation Approaches used for the Management of Osteoarthritis: A Recent Review"],"prefix":"10.2174","volume":"20","author":[{"given":"Mohit","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghav","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam Kumar","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1136\/pmj.79.933.377","volume":"79","author":"Haq I.","year":"2003","unstructured":"Haq I.; Murphy E.; Dacre. J Osteoarthritis Postgrad Med J 2003,79(933),377-383","journal-title":"J Osteoarthritis Postgrad Med J"},{"key":"ref=2","author":"Wittenauer R.","year":"2013","unstructured":"Wittenauer R.; Smith L.; Aden K.; Background Paper 612 Osteoarthritis 2013","journal-title":"Background Paper 612 Osteoarthritis"},{"key":"ref=3","unstructured":"World population to 2300. United Nations Publications: New York, 2004. Available from: https:\/\/www.un.org\/development\/desa\/pd\/sites\/www.un.org.development.desa.pd\/files\/files\/documents\/2020\/Jan\/un_2002_world_population_to_2300.pdf"},{"key":"ref=4","first-page":"21","volume":"8","author":"Burns L.C.","year":"2015","unstructured":"Burns L.C.; Ritvo S.E.; Ferguson M.K.; Clarke H.; Seltzer Z.; Katz J.; Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: A systematic review. J Pain Res 2015,8,21-32","journal-title":"J Pain Res"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/nrrheum.2016.148","volume":"12","author":"Goldring S.R.","year":"2016","unstructured":"Goldring S.R.; Goldring M.B.; Changes in the osteochondral unit during osteoarthritis: Structure, function and cartilage-bone crosstalk. Nat Rev Rheumatol 2016,12(11),632-644","journal-title":"Nat Rev Rheumatol"},{"key":"ref=6","first-page":"64","volume":"37","author":"Deveza L.A.","year":"2019","unstructured":"Deveza L.A.; Nelson A.E.; Loeser R.F.; Phenotypes of osteoarthritis: Current state and future implications. Clin Exp Rheumatol 2019,37(5)(Suppl. 120),64-72","journal-title":"Clin Exp Rheumatol"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.12688\/f1000research.22115.1","volume":"9","author":"Gr&#xE4;ssel S.","year":"2020","unstructured":"Gr&#xE4;ssel S.; Muschter D.; Recent advances in the treatment of osteoarthritis. F1000 Res 2020,9,325","journal-title":"F1000 Res"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/s41584-018-0073-x","volume":"14","author":"Berenbaum F.","year":"2018","unstructured":"Berenbaum F.; Wallace I.J.; Lieberman D.E.; Felson D.T.; Modern-day environmental factors in the pathogenesis of osteoarthritis. Nat Rev Rheumatol 2018,14(11),674-681","journal-title":"Nat Rev Rheumatol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12891-016-1286-2","volume":"17","author":"Dell\u2019Isola A.","year":"2016","unstructured":"Dell\u2019Isola A.; Allan R.; Smith S.L.; Marreiros S.S.P.; Steultjens M.; Identification of clinical phenotypes in knee osteoarthritis: A systematic review of the literature. BMC Musculoskelet Disord 2016,17(1),425","journal-title":"BMC Musculoskelet Disord"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.berh.2011.11.013","volume":"25","author":"Guilak F.","year":"2011","unstructured":"Guilak F.; Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol 2011,25(6),815-823","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.semarthrit.2009.06.001","volume":"39","author":"Brandt K.D.","year":"2009","unstructured":"Brandt K.D.; Dieppe P.; Radin E.L.; Commentary: Is it useful to subset primary osteoarthritis? A critique based on evidence regarding the etiopathogenesis of osteoarthritis. Semin Arthritis Rheum 2009,39,81-95","journal-title":"Semin Arthritis Rheum"},{"key":"ref=12","author":"Moskowitz R.W.","year":"1984","unstructured":"Moskowitz R.W.; Osteoarthritis, Diagnosis and Management 1984","journal-title":"Osteoarthritis, Diagnosis and Management"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/14397595.2016.1232332","volume":"27","author":"Bournia V.K.","year":"2017","unstructured":"Bournia V.K.; Kitas G.; Protogerou A.D.; Sfikakis P.P.; Impact of non-steroidal anti-inflammatory drugs on cardiovascular risk: Is it the same in osteoarthritis and rheumatoid arthritis? Mod Rheumatol 2017,27(4),559-569","journal-title":"Mod Rheumatol"},{"key":"ref=14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0049-0172(97)80046-7","volume":"26","author":"Vane J.R.","year":"1997","unstructured":"Vane J.R.; Botting R.M.; Mechanism of action of aspirin-like drugs. Semin Arthritis Rheum 1997,26,2-10","journal-title":"Semin Arthritis Rheum"},{"key":"ref=15","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000142","volume":"1","author":"Watson M.","year":"1997","unstructured":"Watson M.; Brookes S.T.; Faulkner A.; Kirwan J.R.; Non\u2010aspirin, non\u2010steroidal anti\u2010inflammatory drugs for treating osteoarthritis of the knee. Cochrane Database Syst Rev 1997,1","journal-title":"Cochrane Database Syst Rev"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1136\/ard.45.6.491","volume":"45","author":"Saxne T.","year":"1986","unstructured":"Saxne T.; Heineg&#xE5;rd D.; Wollheim F.A.; Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid. Ann Rheum Dis 1986,45(6),491-497","journal-title":"Ann Rheum Dis"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"638","DOI":"10.5435\/00124635-200910000-00006","volume":"17","author":"Hepper C.T.","year":"2009","unstructured":"Hepper C.T.; Halvorson J.J.; Duncan S.T.; Gregory A.J.M.; Dunn W.R.; Spindler K.P.; The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: A systematic review of level I studies. J Am Acad Orthop Surg 2009,17(10),638-646","journal-title":"J Am Acad Orthop Surg"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1136\/bmj.38039.573970.7C","volume":"328","author":"Arroll B.","year":"2004","unstructured":"Arroll B.; Goodyear-Smith F.; Corticosteroid injections for osteoarthritis of the knee: Meta-analysis. BMJ 2004,328(7444),869","journal-title":"BMJ"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1001\/jama.2018.0899","volume":"319","author":"Krebs E.E.","year":"2018","unstructured":"Krebs E.E.; Gravely A.; Nugent S.; Jensen A.C.; DeRonne B.; Goldsmith E.S.; Kroenke K.; Bair M.J.; Noorbaloochi S.; Effect of opioid vs nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain: The SPACE randomized clinical trial. JAMA 2018,319(9),872-882","journal-title":"JAMA"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/ncprheum0727","volume":"4","author":"Murphy G.","year":"2008","unstructured":"Murphy G.; Nagase H.; Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: Destruction or repair? Nat Clin Pract Rheumatol 2008,4(3),128-135","journal-title":"Nat Clin Pract Rheumatol"},{"key":"ref=21","first-page":"544","volume":"30","author":"Leff R.L.","year":"2003","unstructured":"Leff R.L.; Elias I.; Ionescu M.; Reiner A.; Poole A.R.; Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor. J Rheumatol 2003,30(3),544-549","journal-title":"J Rheumatol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1136\/annrheumdis-2013-204111","volume":"73","author":"Karsdal M.A.","year":"2014","unstructured":"Karsdal M.A.; Bay-Jensen A.C.; Lories R.J.; Abramson S.; Spector T.; Pastoureau P.; Christiansen C.; Attur M.; Henriksen K.; Goldring S.R.; Kraus V.; The coupling of bone and cartilage turnover in osteoarthritis: Opportunities for bone antiresorptives and anabolics as potential treatments? Ann Rheum Dis 2014,73(2),336-348","journal-title":"Ann Rheum Dis"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/j.joca.2010.06.007","volume":"18","author":"Strassle B.W.","year":"2010","unstructured":"Strassle B.W.; Mark L.; Leventhal L.; Piesla M.J.; Li Jian; X.; Kennedy, J.D.; Glasson, S.S.; Whiteside, G.T. Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. Osteoarthritis Cartilage 2010,18(10),1319-1328","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"R625","DOI":"10.1186\/ar1716","volume":"7","author":"Spector T.D.","year":"2005","unstructured":"Spector T.D.; Conaghan P.G.; Buckland-Wright J.C.; Garnero P.; Cline G.A.; Beary J.F.; Valent D.J.; Meyer J.M.; Effect of risedronate on joint structure and symptoms of knee osteoarthritis: Results of the BRISK randomized, controlled trial. Arthritis ResISRCTN01928173 2005,7(3),R625-R633","journal-title":"Arthritis ResISRCTN01928173"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/rheumatology\/kel213","volume":"46","author":"Buckland-Wright J.C.","year":"2006","unstructured":"Buckland-Wright J.C.; Messent E.A.; Bingham C.O.; Ward R.J.; Tonkin C.A.; 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology (Oxford) 2006,46(2),257-264","journal-title":"Rheumatology (Oxford)"},{"key":"ref=26","first-page":"656","volume":"50","author":"Gamero P.","year":"2004","unstructured":"Gamero P.; Bingham C.; Aronstein W.; Cohen S.; Conaghan P.; Cline G.; Meyer J.; Treatment with risedronate reduced urinary CTX-II, a specific biochemical marker of cartilage type II collagen degradation, in a 24-month study of knee OA. Arthritis Rheum 2004,50,656","journal-title":"Arthritis Rheum"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.2165\/00063030-200822030-00001","volume":"22","author":"Karsdal M.A.","year":"2008","unstructured":"Karsdal M.A.; Henriksen K.; Arnold M.; Christiansen C.; Calcitonin??? A drug of the past or for the future? BioDrugs 2008,22(3),137-144","journal-title":"BioDrugs"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1359\/JBMR.040609","volume":"19","author":"Behets C.","year":"2004","unstructured":"Behets C.; Williams J.M.; Chappard D.; Devogelaer J.P.; Manicourt D.H.; Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency. J Bone Miner Res 2004,19(11),1821-1826","journal-title":"J Bone Miner Res"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1002\/art.22797","volume":"56","author":"Sondergaard B.C.","year":"2007","unstructured":"Sondergaard B.C.; Oestergaard S.; Christiansen C.; Tank&#xF3; L.B.; Karsdal M.A.; The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum 2007,56(8),2674-2678","journal-title":"Arthritis Rheum"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.joca.2006.03.014","volume":"14","author":"Karsdal M.A.","year":"2006","unstructured":"Karsdal M.A.; Tanko L.B.; Riis B.J.; Sondergard B.C.; Henriksen K.; Altman R.D.; Qvist P.; Christiansen C.; Calcitonin is involved in cartilage homeostasis: Is calcitonin a treatment for OA? Osteoarthritis Cartilage 2006,14(7),617-624","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1002\/art.22075","volume":"54","author":"Manicourt D.H.","year":"2006","unstructured":"Manicourt D.H.; Azria M.; Mindeholm L.; Thonar E.J.M.; Devogelaer J.P.; Oral salmon calcitonin reduces Lequesne\u2019s algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis. Arthritis Rheum 2006,54(10),3205-3211","journal-title":"Arthritis Rheum"},{"key":"ref=32","first-page":"88","volume":"13","author":"Manicourt D.H.","year":"2005","unstructured":"Manicourt D.H.; Azria M.; Mindeholm L.; Devogelaer J.P.; Efficacy of calcitonin therapy in patients with knee osteoarthritis: A clinical and biochemical preliminary study. Osteoarthritis Cartilage 2005,13(Suppl. A),88","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.joca.2014.12.019","volume":"23","author":"Karsdal M.A.","year":"2015","unstructured":"Karsdal M.A.; Byrjalsen I.; Alexandersen P.; Bihlet A.; Andersen J.R.; Riis B.J.; Bay-Jensen A.C.; Christiansen C.; Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: Results from two phase 3 trials. Osteoarthritis Cartilage 2015,23(4),532-543","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/art.23220","volume":"58","author":"Lee S.W.","year":"2008","unstructured":"Lee S.W.; Song Y.S.; Shin S.H.; Kim K.T.; Park Y.C.; Park B.S.; Yun I.; Kim K.; Lee S.Y.; Chung W.T.; Lee H.J.; Yoo Y.H.; Cilostazol protects rat chondrocytes against nitric oxide-induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis. Arthritis Rheum 2008,58(3),790-800","journal-title":"Arthritis Rheum"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1136\/annrheumdis-2012-202239","volume":"72","author":"Hellio le Graverand M.P.","year":"2013","unstructured":"Hellio le Graverand M.P.; Clemmer R.S.; Redifer P.; Brunell R.M.; Hayes C.W.; Brandt K.D.; Abramson S.B.; Manning P.T.; Miller C.G.; Vignon E.; A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis 2013,72(2),187-195","journal-title":"Ann Rheum Dis"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.mri.2011.09.025","volume":"30","author":"Pinney J.R.","year":"2012","unstructured":"Pinney J.R.; Taylor C.; Doan R.; Burghardt A.J.; Li X.; Kim H.T.; Benjamin Ma C.; Majumdar S.; Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis. Magn Reson Imaging 2012,30(2),271-282","journal-title":"Magn Reson Imaging"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1002\/art.21122","volume":"52","author":"Brandt K.D.","year":"2005","unstructured":"Brandt K.D.; Mazzuca S.A.; Katz B.P.; Lane K.A.; Buckwalter K.A.; Yocum D.E.; Wolfe F.; Schnitzer T.J.; Moreland L.W.; Manzi S.; Bradley J.D.; Sharma L.; Oddis C.V.; Hugenberg S.T.; Heck L.W.; Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 2005,52(7),2015-2025","journal-title":"Arthritis Rheum"},{"key":"ref=38","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007323.pub2","volume":"4","author":"N&#xFC;esch E.","year":"2009","unstructured":"N&#xFC;esch E.; Rutjes A.W.S.; Trelle S.; Reichenbach S.; J&#xFC;ni P.; Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev 2009,4","journal-title":"Cochrane Database Syst Rev"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1056\/NEJMoa022436","volume":"350","author":"Meunier P.J.","year":"2004","unstructured":"Meunier P.J.; Roux C.; Seeman E.; Ortolani S.; Badurski J.E.; Spector T.D.; Cannata J.; Balogh A.; Lemmel E.M.; Pors-Nielsen S.; Rizzoli R.; Genant H.K.; Reginster J.Y.; The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004,350(5),459-468","journal-title":"N Engl J Med"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.bone.2006.07.028","volume":"40","author":"Alexandersen P.","year":"2007","unstructured":"Alexandersen P.; Karsdal M.A.; Qvist P.; Reginster J-Y.; Christiansen C.; Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women. Bone 2007,40(1),218-222","journal-title":"Bone"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1136\/annrheumdis-2012-202231","volume":"72","author":"Reginster J.Y.","year":"2013","unstructured":"Reginster J.Y.; Badurski J.; Bellamy N.; Bensen W.; Chapurlat R.; Chevalier X.; Christiansen C.; Genant H.; Navarro F.; Nasonov E.; Sambrook P.N.; Spector T.D.; Cooper C.; Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: Results of a double-blind, randomised placebo-controlled trial. Ann Rheum Dis 2013,72(2),179-186","journal-title":"Ann Rheum Dis"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1126\/science.284.5420.1664","volume":"284","author":"Tortorella M.D.","year":"1999","unstructured":"Tortorella M.D.; Burn T.C.; Pratta M.A.; Abbaszade I.; Hollis J.M.; Liu R.; Rosenfeld S.A.; Copeland R.A.; Decicco C.P.; Wynn R.; Rockwell A.; Yang F.; Duke J.L.; Solomon K.; George H.; Bruckner R.; Nagase H.; Itoh Y.; Ellis D.M.; Ross H.; Wiswall B.H.; Murphy K.; Hillman M.C.; Hollis G.F.; Newton R.C.; Magolda R.L.; Trzaskos J.M.; Arner E.C.; Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins. Science 1999,284(5420),1664-1666","journal-title":"Science"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.joca.2015.02.778","volume":"23","author":"Larkin J.","year":"2015","unstructured":"Larkin J.; Lohr T.A.; Elefante L.; Shearin J.; Matico R.; Su J.L.; Xue Y.; Liu F.; Genell C.; Miller R.E.; Tran P.B.; Malfait A.M.; Maier C.C.; Matheny C.J.; Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage 2015,23(8),1254-1266","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.joca.2009.03.015","volume":"17","author":"Connor J.R.","year":"2009","unstructured":"Connor J.R.; LePage C.; Swift B.A.; Yamashita D.; Bendele A.M.; Maul D.; Kumar S.; Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis. Osteoarthritis Cartilage 2009,17(9),1236-1243","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/j.joca.2010.07.014","volume":"18","author":"McDougall J.J.","year":"2010","unstructured":"McDougall J.J.; Schuelert N.; Bowyer J.; Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis. Osteoarthritis Cartilage 2010,18(10),1355-1357","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.bone.2012.03.025","volume":"50","author":"Hayami T.","year":"2012","unstructured":"Hayami T.; Zhuo Y.; Wesolowski G.A.; Pickarski M.; Duong L.T.; Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. Bone 2012,50(6),1250-1259","journal-title":"Bone"},{"key":"ref=47","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1359\/jbmr.091035","volume":"25","author":"Bone H.G.","year":"2010","unstructured":"Bone H.G.; McClung M.R.; Roux C.; Recker R.R.; Eisman J.A.; Verbruggen N.; Hustad C.M.; DaSilva C.; Santora A.C.; Ince B.A.; Odanacatib, a cathepsin-K inhibitor for osteoporosis: A two-year study in postmenopausal women with low bone density. J Bone Miner Res 2010,25(5),937-947","journal-title":"J Bone Miner Res"},{"key":"ref=48","first-page":"PP6","volume":"3","author":"Grabowska U.","year":"2014","unstructured":"Grabowska U.; Lindstrom E.; Jerling M.; Edenius C.; MIV-711, a highly selective cathepsin K inhibitor: Safety, pharmacokinetics and pharmacodynamics of multiple oral doses in healthy postmenopausal women. Bone Abstracts 2014,3,PP6","journal-title":"Bone Abstracts"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1016\/j.jaad.2010.11.033","volume":"66","author":"Rnger T.M.","year":"2012","unstructured":"Rnger T.M.; Adami S.; Benhamou C.L.; Czerwiski E.; Farrerons J.; Kendler D.L.; Mindeholm L.; Realdi G.; Roux C.; Smith V.; Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib. J Am Acad Dermatol 2012,66(3),e89-e96","journal-title":"J Am Acad Dermatol"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/ard.62.4.332","volume":"62","author":"Mouritzen U.","year":"2003","unstructured":"Mouritzen U.; Christgau S.; Lehmann H.J.; Tank&#xF3; L.B.; Christiansen C.; Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: Influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 2003,62(4),332-336","journal-title":"Ann Rheum Dis"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1002\/art.10406","volume":"46","author":"Ham K.D.","year":"2002","unstructured":"Ham K.D.; Loeser R.F.; Lindgren B.R.; Carlson C.S.; Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum 2002,46(7),1956-1964","journal-title":"Arthritis Rheum"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1002\/art.22009","volume":"54","author":"Oestergaard S.","year":"2006","unstructured":"Oestergaard S.; Sondergaard B.C.; Hoegh-Andersen P.; Henriksen K.; Qvist P.; Christiansen C.; Tank&#xF3; L.B.; Karsdal M.A.; Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: Implications of the time of initiation. Arthritis Rheum 2006,54(8),2441-2451","journal-title":"Arthritis Rheum"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1002\/art.22138","volume":"54","author":"Cirillo D.J.","year":"2006","unstructured":"Cirillo D.J.; Wallace R.B.; Wu L.; Yood R.A.; Effect of hormone therapy on risk of hip and knee joint replacement in the women\u2019s health initiative. Arthritis Rheum 2006,54(10),3194-3204","journal-title":"Arthritis Rheum"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1097\/01.WCB.0000121484.18437.98","volume":"11","author":"Christgau S.","year":"2004","unstructured":"Christgau S.; Tank&#xF3; L.B.; Cloos P.A.C.; Mouritzen U.; Christiansen C.; Delaiss&#xE9; J.M.; H&#xF8;egh-Andersen P.; Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a Selective Estrogen-Receptor Modulator (SERM). Menopause 2004,11(5),508-518","journal-title":"Menopause"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1258\/mi.2012.012025","volume":"18","author":"Karsdal M.A.","year":"2012","unstructured":"Karsdal M.A.; Bay-Jensen A.C.; Henriksen K.; Christiansen C.; The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: May estrogen be a magic bullet? Menopause Int 2012,18(4),139-146","journal-title":"Menopause Int"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.joca.2008.05.006","volume":"17","author":"Elder B.D.","year":"2009","unstructured":"Elder B.D.; Athanasiou K.A.; Systematic assessment of growth factor treatment on biochemical and biomechanical properties of engineered articular cartilage constructs. Osteoarthritis Cartilage 2009,17(1),114-123","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1002\/jor.21165","volume":"28","author":"Hayashi M.","year":"2010","unstructured":"Hayashi M.; Muneta T.; Takahashi T.; Ju Y.J.; Tsuji K.; Sekiya I.; Intra-articular injections of bone morphogenetic protein-7 retard progression of existing cartilage degeneration. J Orthop Res 2010,28(11),1502-1506","journal-title":"J Orthop Res"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.addr.2012.03.014","volume":"64","author":"Lo K.W.H.","year":"2012","unstructured":"Lo K.W.H.; Ulery B.D.; Ashe K.M.; Laurencin C.T.; Studies of bone morphogenetic protein-based surgical repair. Adv Drug Deliv Rev 2012,64(12),1277-1291","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/1471-2474-11-232","volume":"11","author":"Hunter D.J.","year":"2010","unstructured":"Hunter D.J.; Pike M.C.; Jonas B.L.; Kissin E.; Krop J.; McAlindon T.; Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis. BMC Musculoskelet Disord 2010,11(1),232","journal-title":"BMC Musculoskelet Disord"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.joca.2005.03.003","volume":"13","author":"Moore E.E.","year":"2005","unstructured":"Moore E.E.; Bendele A.M.; Thompson D.L.; Littau A.; Waggie K.S.; Reardon B.; Ellsworth J.L.; Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage 2005,13(7),623-631","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1002\/art.38614","volume":"66","author":"Lohmander L.S.","year":"2014","unstructured":"Lohmander L.S.; Hellot S.; Dreher D.; Krantz E.F.W.; Kruger D.S.; Guermazi A.; Eckstein F.; Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: A randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol 2014,66(7),1820-1831","journal-title":"Arthritis Rheumatol"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1136\/ard.52.12.870","volume":"52","author":"Farahat M.N.","year":"1993","unstructured":"Farahat M.N.; Yanni G.; Poston R.; Panayi G.S.; Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 1993,52(12),870-875","journal-title":"Ann Rheum Dis"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","volume":"51","author":"Scanzello C.R.","year":"2012","unstructured":"Scanzello C.R.; Goldring S.R.; The role of synovitis in osteoarthritis pathogenesis. Bone 2012,51(2),249-257","journal-title":"Bone"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"R125","DOI":"10.1186\/ar3430","volume":"13","author":"Cohen S.B.","year":"2011","unstructured":"Cohen S.B.; Proudman S.; Kivitz A.J.; Burch F.X.; Donohue J.P.; Burstein D.; Sun Y.N.; Banfield C.; Vincent M.S.; Ni L.; Zack D.J.; A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res Ther 2011,13(4),R125","journal-title":"Arthritis Res Ther"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1055\/s-2007-971629","volume":"42","author":"Akhtar M.","year":"1981","unstructured":"Akhtar M.; Athar M.; Yaqub M.; Effect of Momordica charantia on blood glucose level of normal and alloxan-diabetic rabbits. Planta Med 1981,42(7),205-212","journal-title":"Planta Med"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1080\/19420862.2015.1026501","volume":"Vol. 7","author":"Lacy S.E.","year":"2015","unstructured":"Lacy S.E.; Wu C.; Ambrosi D.J.; Hsieh C-M.; Bose S.; Miller R.; Ghayur T.; Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1&#x3B1; and IL-1&#x3B2;. MAbs 2015,Vol. 7,605-619","journal-title":"MAbs"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/ar2301","volume":"9","author":"Hopwood B.","year":"2007","unstructured":"Hopwood B.; Tsykin A.; Findlay D.M.; Fazzalari N.L.; Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-&#x3B2;\/bone morphogenic protein signalling. Arthritis Res Ther 2007,9(5),R100","journal-title":"Arthritis Res Ther"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.joca.2014.03.004","volume":"22","author":"Tonge D.P.","year":"2014","unstructured":"Tonge D.P.; Pearson M.J.; Jones S.W.; The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics. Osteoarthritis Cartilage 2014,22(5),609-621","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","volume":"10","author":"Evans C.H.","year":"2014","unstructured":"Evans C.H.; Kraus V.B.; Setton L.A.; Progress in intra-articular therapy. Nat Rev Rheumatol 2014,10(1),11-22","journal-title":"Nat Rev Rheumatol"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bcp.2019.02.037","volume":"165","author":"Van Spil W.E.","year":"2019","unstructured":"Van Spil W.E.; Kubassova O.; Boesen M.; Bay-Jensen A.C.; Mobasheri A.; Osteoarthritis phenotypes and novel therapeutic targets. Biochem Pharmacol 2019,165,41-48","journal-title":"Biochem Pharmacol"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.joca.2017.11.013","volume":"26","author":"Vaysbrot E.E.","year":"2018","unstructured":"Vaysbrot E.E.; Osani M.C.; Musetti M.C.; McAlindon T.E.; Bannuru R.R.; Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis Cartilage 2018,26(2),154-164","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"86","DOI":"10.7326\/M19-0675","volume":"172","author":"Conaghan P.G.","year":"2020","unstructured":"Conaghan P.G.; Bowes M.A.; Kingsbury S.R.; Brett A.; Guillard G.; Rizoska B.; Sj&#xF6;gren N.; Graham P.; Jansson &#xC5;.; Wadell C.; Bethell R.; &#xD6;hd J.; Disease-modifying effects of a novel cathepsin K inhibitor in osteoarthritis: A randomized controlled trial. Ann Intern Med 2020,172(2),86-95","journal-title":"Ann Intern Med"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/art.24096","volume":"61","author":"Chevalier X.","year":"2009","unstructured":"Chevalier X.; Goupille P.; Beaulieu A.D.; Burch F.X.; Bensen W.G.; Conrozier T.; Loeuille D.; Kivitz A.J.; Silver D.; Appleton B.E.; Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 2009,61(3),344-352","journal-title":"Arthritis Rheum"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/ar3436","volume":"13","author":"Chevalier X.","year":"2011","unstructured":"Chevalier X.; Conrozier T.; Richette P.; Desperately looking for the right target in osteoarthritis: The anti-IL-1 strategy. Arthritis Res Ther 2011,13(4),124","journal-title":"Arthritis Res Ther"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1002\/art.40840","volume":"71","author":"Fleischmann R.M.","year":"2019","unstructured":"Fleischmann R.M.; Bliddal H.; Blanco F.J.; Schnitzer T.J.; Peterfy C.; Chen S.; Wang L.; Feng S.; Conaghan P.G.; Berenbaum F.; Pelletier J.P.; Martel-Pelletier J.; Vaeterlein O.; Kaeley G.S.; Liu W.; Kosloski M.P.; Levy G.; Zhang L.; Medema J.K.; Levesque M.C.; A Phase II trial of lutikizumab, an anti\u2013interleukin\u20101&#x3B1;\/&#x3B2; dual variable domain immunoglobulin, in knee osteoarthritis patients with synovitis. Arthritis Rheumatol 2019,71(7),1056-1069","journal-title":"Arthritis Rheumatol"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.joca.2018.02.899","volume":"26","author":"Aitken D.","year":"2018","unstructured":"Aitken D.; Laslett L.L.; Pan F.; Haugen I.K.; Otahal P.; Bellamy N.; Bird P.; Jones G.; A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis \u2013 the HUMOR trial. Osteoarthritis Cartilage 2018,26(7),880-887","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1136\/annrheumdis-2018-213202","volume":"77","author":"Kloppenburg M.","year":"2018","unstructured":"Kloppenburg M.; Ramonda R.; Bobacz K.; Kwok W.Y.; Elewaut D.; Huizinga T.W.J.; Kroon F.P.B.; Punzi L.; Smolen J.S.; Vander Cruyssen B.; Wolterbeek R.; Verbruggen G.; Wittoek R.; Etanercept in patients with inflammatory hand osteoarthritis (EHOA): A multicentre, randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 2018,77(12),1757-1764","journal-title":"Ann Rheum Dis"},{"key":"ref=78","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1093\/rheumatology\/key016","volume":"57","author":"Loef M.","year":"2018","unstructured":"Loef M.; Kroon F.P.B.; Bergstra S.A.; van der Pol J.A.; Lems W.F.; Kerstens P.J.S.M.; Allaart C.F.; Kloppenburg M.; TNF inhibitor treatment is associated with a lower risk of hand osteoarthritis progression in rheumatoid arthritis patients after 10 years. Rheumatology (Oxford) 2018,57(11),1917-1924","journal-title":"Rheumatology (Oxford)"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1002\/acr.23471","volume":"70","author":"Lee W.","year":"2018","unstructured":"Lee W.; Ruijgrok L.; Boxma-de Klerk B.; Kok M.R.; Kloppenburg M.; Gerards A.; Huisman M.; Hazes M.; de Sonnaville P.; Grillet B.; Weel A.; Basoski N.; Efficacy of hydroxychloroquine in hand osteoarthritis: A randomized, double\u2010blind, placebo\u2010controlled trial. Arthritis Care Res (Hoboken) 2018,70(9),1320-1325","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.joca.2016.08.010","volume":"25","author":"Grothe K.","year":"2017","unstructured":"Grothe K.; Flechsenhar K.; Paehler T.; Ritzeler O.; Beninga J.; Saas J.; Herrmann M.; Rudolphi K.; I&#x3BA;B kinase inhibition as a potential treatment of osteoarthritis - results of a clinical proof-of-concept study. Osteoarthritis Cartilage 2017,25(1),46-52","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1001\/jama.2019.8044","volume":"322","author":"Schnitzer T.J.","year":"2019","unstructured":"Schnitzer T.J.; Easton R.; Pang S.; Levinson D.J.; Pixton G.; Viktrup L.; Davignon I.; Brown M.T.; West C.R.; Verburg K.M.; Effect of tanezumab on joint pain, physical function, and patient global assessment of osteoarthritis among patients with osteoarthritis of the hip or knee: A randomized clinical trial. JAMA 2019,322(1),37-48","journal-title":"JAMA"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1016\/j.joca.2019.05.028","volume":"27","author":"Krupka E.","year":"2019","unstructured":"Krupka E.; Jiang G.L.; Jan C.; Efficacy and safety of intra-articular injection of tropomyosin receptor kinase A inhibitor in painful knee osteoarthritis: A randomized, double-blind and placebo-controlled study. Osteoarthritis Cartilage 2019,27(11),1599-1607","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1515\/sjpain-2017-0184","volume":"18","author":"Manitpisitkul P.","year":"2018","unstructured":"Manitpisitkul P.; Flores C.M.; Moyer J.A.; Romano G.; Shalayda K.; Tatikola K.; Hutchison J.S.; Mayorga A.J.; A multiple-dose double-blind randomized study to evaluate the safety, pharmacokinetics, pharmacodynamics and analgesic efficacy of the TRPV1 antagonist JNJ-39439335 (mavatrep). Scand J Pain 2018,18(2),151-164","journal-title":"Scand J Pain"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.joca.2018.08.019","volume":"26","author":"Jin Y.","year":"2018","unstructured":"Jin Y.; Smith C.; Monteith D.; Brown R.; Camporeale A.; McNearney T.A.; Deeg M.A.; Raddad E.; Xiao N.; de la Pe&#xF1;a A.; Kivitz A.J.; Schnitzer T.J.; CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial. Osteoarthritis Cartilage 2018,26(12),1609-1618","journal-title":"Osteoarthritis Cartilage"},{"key":"ref=85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086980","volume":"9","author":"Ruggles D.R.","year":"2014","unstructured":"Ruggles D.R.; Freyman R.L.; Oxenham A.J.; Influence of musical training on understanding voiced and whispered speech in noise. PLoS One 2014,9(1)","journal-title":"PLoS One"},{"key":"ref=86","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jare.2013.07.006","volume":"6","author":"Ahmed E.M.","year":"2015","unstructured":"Ahmed E.M.; Hydrogel: Preparation, characterization, and applications: A review. J Adv Res 2015,6(2),105-121","journal-title":"J Adv Res"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"546","DOI":"10.2174\/138945010791011866","volume":"11","author":"Chevalier X.","year":"2010","unstructured":"Chevalier X.; Intraarticular treatments for osteoarthritis: New perspectives. Curr Drug Targets 2010,11(5),546-560","journal-title":"Curr Drug Targets"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1586\/erd.11.27","volume":"8","author":"Zhu J.","year":"2011","unstructured":"Zhu J.; Marchant R.E.; Design properties of hydrogel tissue-engineering scaffolds. Expert Rev Med Devices 2011,8(5),607-626","journal-title":"Expert Rev Med Devices"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.2174\/1381612821666150115150712","volume":"21","author":"Censi R.","year":"2015","unstructured":"Censi R.; Dubbini A.; Matricardi P.; Bioactive hydrogel scaffolds - advances in cartilage regeneration through controlled drug delivery. Curr Pharm Des 2015,21(12),1545-1555","journal-title":"Curr Pharm Des"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.actbio.2021.01.041","volume":"124","author":"Ren X.","year":"2021","unstructured":"Ren X.; Wang N.; Zhou Y.; Song A.; Jin G.; Li Z.; Luan Y.; An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway. Acta Biomater 2021,124,179-190","journal-title":"Acta Biomater"},{"key":"ref=91","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202200801","volume":"32","author":"Zhao Z.","year":"2022","unstructured":"Zhao Z.; Li Q.; Qin X.; Zhang M.; Du Q.; Luan Y.; An injectable hydrogel reshaping adenosinergic axis for cancer therapy. Adv Funct Mater 2022,32(24)","journal-title":"Adv Funct Mater"},{"key":"ref=92","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/748909","volume":"2012","author":"Zhang Z.","year":"2012","unstructured":"Zhang Z.; Huang G.; Micro-and nano-carrier mediated intra-articular drug delivery systems for the treatment of osteoarthritis. J Nanotechnol 2012,2012","journal-title":"J Nanotechnol"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"156","DOI":"10.22270\/jddt.v11i2-S.4792","volume":"11","author":"Raj H.","year":"2021","unstructured":"Raj H.; Sharma S.; Sharma A.; Verma K.K.; Chaudhary A.; A novel drug delivery system: Review on microspheres. J Drug Deliv Ther 2021,11(2-S),156-161","journal-title":"J Drug Deliv Ther"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"R72","DOI":"10.1186\/ar2701","volume":"11","author":"Butoescu N.","year":"2009","unstructured":"Butoescu N.; Seemayer C.A.; Palmer G.; Guerne P.A.; Gabay C.; Doelker E.; Jordan O.; Magnetically retainable microparticles for drug delivery to the joint: Efficacy studies in an antigen-induced arthritis model in mice. Arthritis Res Ther 2009,11(3),R72","journal-title":"Arthritis Res Ther"},{"key":"ref=95","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/jps.22266","volume":"100","author":"Natarajan V.","year":"2011","unstructured":"Natarajan V.; Krithica N.; Madhan B.; Sehgal P.K.; Formulation and evaluation of quercetin polycaprolactone microspheres for the treatment of rheumatoid arthritis. J Pharm Sci 2011,100(1),195-205","journal-title":"J Pharm Sci"},{"key":"ref=96","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102081","volume":"60","author":"Musumeci T.","year":"2020","unstructured":"Musumeci T.; Bonaccorso A.; Carbone C.; Impallomeni G.; Ballistreri A.; Duskey J.T.; Puglisi G.; Pignatello R.; Development and biocompatibility assessments of poly(3-hydroxybutyrate-co-&#x3B5;-caprolactone) microparticles for diclofenac sodium delivery. J Drug Deliv Sci Technol 2020,60","journal-title":"J Drug Deliv Sci Technol"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1021\/acsabm.9b00232","volume":"2","author":"Sulistio A.","year":"2019","unstructured":"Sulistio A.; Mansfeld F.M.; Reyes-Ortega F.; D\u2019Souza A.M.; Ng S.M.Y.; Birkett S.; Blencowe A.; Qiao G.G.; Little C.B.; Shu C.C.; Bendele A.M.; Valade D.; Donohue A.C.; Quinn J.F.; Whittaker M.R.; Davis T.P.; Tait R.J.; Intra-articular treatment of osteoarthritis with diclofenac-conjugated polymer reduces inflammation and pain. ACS Appl Bio Mater 2019,2(7),2822-2832","journal-title":"ACS Appl Bio Mater"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3389\/fchem.2019.00677","volume":"7","author":"Wang S.J.","year":"2019","unstructured":"Wang S.J.; Qin J.Z.; Zhang T.E.; Xia C.; Intra-articular injection of kartogenin-incorporated thermogel enhancing osteoarthritis treatment. Front Chem 2019,7,677","journal-title":"Front Chem"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1002\/app.34332","volume":"122","author":"Miao B.","year":"2011","unstructured":"Miao B.; Song C.; Ma G.; Injectable thermosensitive hydrogels for intra-articular delivery of methotrexate. J Appl Polym Sci 2011,122(3),2139-2145","journal-title":"J Appl Polym Sci"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1080\/10717544.2018.1461279","volume":"25","author":"Fan W.","year":"2018","unstructured":"Fan W.; Li J.; Yuan L.; Chen J.; Wang Z.; Wang Y.; Guo C.; Mo X.; Yan Z.; Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis. Drug Deliv 2018,25(1),1004-1012","journal-title":"Drug Deliv"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1177\/1947603518796550","volume":"11","author":"Mok S.W.","year":"2020","unstructured":"Mok S.W.; Fu S.C.; Cheuk Y.C.; Chu I.M.; Chan K.M.; Qin L.; Yung S.H.; Kevin Ho K.W.; Intra-articular delivery of quercetin using thermosensitive hydrogel attenuate cartilage degradation in an osteoarthritis rat model. Cartilage 2020,11(4),490-499","journal-title":"Cartilage"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"7430","DOI":"10.1038\/s41598-019-43834-y","volume":"9","author":"Liu X.","year":"2019","unstructured":"Liu X.; Corciulo C.; Arabagian S.; Ulman A.; Cronstein B.N.; Adenosine-functionalized biodegradable PLA-b-PEG nanoparticles ameliorate osteoarthritis in rats. Sci Rep 2019,9(1),7430","journal-title":"Sci Rep"},{"key":"ref=103","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12951-020-00666-7","volume":"18","author":"Lan Q.","year":"2020","unstructured":"Lan Q.; Lu R.; Chen H.; Pang Y.; Xiong F.; Shen C.; Qin Z.; Zheng L.; Xu G.; Zhao J.; MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis. J Nanobiotechnology 2020,18(1),117","journal-title":"J Nanobiotechnology"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1166\/jnn.2018.14311","volume":"18","author":"Jiang T.","year":"2018","unstructured":"Jiang T.; Kan H.M.; Rajpura K.; Carbone E.J.; Li Y.; Lo K.W.H.; Development of targeted nanoscale drug delivery system for osteoarthritic cartilage tissue. J Nanosci Nanotechnol 2018,18(4),2310-2317","journal-title":"J Nanosci Nanotechnol"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jconrel.2017.05.008","volume":"258","author":"McMasters J.","year":"2017","unstructured":"McMasters J.; Poh S.; Lin J.B.; Panitch A.; Delivery of anti-inflammatory peptides from hollow PEGylated poly(NIPAM) nanoparticles reduces inflammation in an ex vivo osteoarthritis model. J Control Release 2017,258,161-170","journal-title":"J Control Release"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"18743","DOI":"10.1038\/srep18743","volume":"6","author":"Aini H.","year":"2016","unstructured":"Aini H.; Itaka K.; Fujisawa A.; Uchida H.; Uchida S.; Fukushima S.; Kataoka K.; Saito T.; Chung U.; Ohba S.; Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep 2016,6(1),18743","journal-title":"Sci Rep"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"7665","DOI":"10.1016\/j.biomaterials.2012.06.101","volume":"33","author":"Whitmire R.E.","year":"2012","unstructured":"Whitmire R.E.; Scott Wilson D.; Singh A.; Levenston M.E.; Murthy N.; Garc&#xED;a A.J.; Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins. Biomaterials 2012,33(30),7665-7675","journal-title":"Biomaterials"},{"key":"ref=108","doi-asserted-by":"publisher","first-page":"20713","DOI":"10.1039\/C5RA24516H","volume":"6","author":"Sharma G.","year":"2016","unstructured":"Sharma G.; Kaur M.; Raza K.; Thakur K.; Katare O.P.; Aceclofenac-&#x3B2;-cyclodextrin-vesicles: A dual carrier approach for skin with enhanced stability, efficacy and dermatokinetic profile. RSC Adv 2016,6(25),20713-20727","journal-title":"RSC Adv"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"10564","DOI":"10.1002\/chem.202001372","volume":"26","author":"Zhang K.","year":"2020","unstructured":"Zhang K.; Yang J.; Sun Y.; Liang J.; Cui W.; Deng L.; Zhang H.; Thermo-sensitive dual-functional nanospheres with enhanced lubrication and drug delivery for the treatment of osteoarthritis. Chemistry 2020,26(46),10564-10574","journal-title":"Chemistry"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1021\/acsbiomaterials.8b00116","volume":"4","author":"Sandker M.J.","year":"2018","unstructured":"Sandker M.J.; Duque L.F.; Redout E.M.; Klijnstra E.C.; Steendam R.; Kops N.; Waarsing J.H.; van Weeren R.; Hennink W.E.; Weinans H.; Degradation, intra-articular biocompatibility, drug release, and bioactivity of tacrolimus-loaded poly(d-l -lactide-PEG)- b -poly(l -lactide) multiblock copolymer-based monospheres. ACS Biomater Sci Eng 2018,4(7),2390-2403","journal-title":"ACS Biomater Sci Eng"},{"key":"ref=111","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jconrel.2016.11.003","volume":"244","author":"Janssen M.","year":"2016","unstructured":"Janssen M.; Timur U.T.; Woike N.; Welting T.J.M.; Draaisma G.; Gijbels M.; van Rhijn L.W.; Mihov G.; Thies J.; Emans P.J.; Celecoxib-loaded PEA microspheres as an auto regulatory drugdelivery system after intra-articular injection. J Control Release 2016,244(Pt A)),30-40","journal-title":"J Control Release"},{"key":"ref=112","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3109\/10717544.2012.700962","volume":"19","author":"Zhang Z.","year":"2012","unstructured":"Zhang Z.; Huang G.; Intra-articular lornoxicam loaded PLGA microspheres: Enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis. Drug Deliv 2012,19(5),255-263","journal-title":"Drug Deliv"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1016\/j.actbio.2012.03.015","volume":"8","author":"Eswaramoorthy R.","year":"2012","unstructured":"Eswaramoorthy R.; Chang C.C.; Wu S.C.; Wang G.J.; Chang J.K.; Ho M.L.; Sustained release of PTH(1\u201334) from PLGA microspheres suppresses osteoarthritis progression in rats. Acta Biomater 2012,8(6),2254-2262","journal-title":"Acta Biomater"},{"key":"ref=114","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1002\/jor.23562","volume":"35","author":"Goto N.","year":"2017","unstructured":"Goto N.; Okazaki K.; Akasaki Y.; Ishihara K.; Murakami K.; Koyano K.; Ayukawa Y.; Yasunami N.; Masuzaki T.; Nakashima Y.; Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis. J Orthop Res 2017,35(11),2465-2475","journal-title":"J Orthop Res"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.1016\/j.biomaterials.2013.03.066","volume":"34","author":"Ko J.Y.","year":"2013","unstructured":"Ko J.Y.; Choi Y.J.; Jeong G.J.; Im G.I.; Sulforaphane\u2013PLGA microspheres for the intra-articular treatment of osteoarthritis. Biomaterials 2013,34(21),5359-5368","journal-title":"Biomaterials"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/medicines7110067","volume":"7","author":"Lindler B.N.","year":"2020","unstructured":"Lindler B.N.; Long K.E.; Taylor N.A.; Lei W.; Use of herbal medications for treatment of osteoarthritis and rheumatoid arthritis. Medicines (Basel) 2020,7(11),67","journal-title":"Medicines (Basel)"},{"key":"ref=117","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.2174\/1386207323999201110192942","volume":"24","author":"Barkat M.A.","year":"2021","unstructured":"Barkat M.A.; Goyal A.; Barkat H.A.; Salauddin M.; Pottoo F.H.; Anwer E.T.; Herbal medicine: Clinical perspective and regulatory status. Comb Chem High Throughput Screen 2021,24(10),1573-1582","journal-title":"Comb Chem High Throughput Screen"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/art.40400","volume":"70","author":"Solomon D.H.","year":"2018","unstructured":"Solomon D.H.; Husni M.E.; Wolski K.E.; Wisniewski L.M.; Borer J.S.; Graham D.Y.; Libby P.; Lincoff A.M.; L&#xFC;scher T.F.; Menon V.; Yeomans N.D.; Wang Q.; Bao W.; Berger M.F.; Nissen S.E.; Differences in safety of nonsteroidal antiinflammatory drugs in patients with osteoarthritis and patients with rheumatoid arthritis: A randomized clinical trial. Arthritis Rheumatol 2018,70(4),537-546","journal-title":"Arthritis Rheumatol"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/2327-6924.12139","volume":"26","author":"Fowler T.O.","year":"2014","unstructured":"Fowler T.O.; Durham C.O.; Planton J.; Edlund B.J.; Use of nonsteroidal anti-inflammatory drugs in the older adult. J Am Assoc Nurse Pract 2014,26(8),414-423","journal-title":"J Am Assoc Nurse Pract"},{"key":"ref=120","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004257.pub2","volume":"2006","author":"Towheed T.","year":"2006","unstructured":"Towheed T.; Maxwell L.; Judd M.; Catton M.; Hochberg M.C.; Wells G.A.; Acetaminophen for osteoarthritis. Cochrane Database Syst Rev 2006,2006(1)","journal-title":"Cochrane Database Syst Rev"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.biopha.2015.01.022","volume":"70","author":"Vazzana M.","year":"2015","unstructured":"Vazzana M.; Andreani T.; Fangueiro J.; Faggio C.; Silva C.; Santini A.; Garcia M.L.; Silva A.M.; Souto E.B.; Tramadol hydrochloride: Pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomed Pharmacother 2015,70,234-238","journal-title":"Biomed Pharmacother"},{"key":"ref=122","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.2106\/JBJS.15.01358","volume":"98","author":"Weick J.W.","year":"2016","unstructured":"Weick J.W.; Bawa H.S.; Dirschl D.R.; Hyaluronic acid injections for treatment of advanced osteoarthritis of the knee: Utilization and cost in a national population sample. J Bone Joint Surg Am 2016,98(17),1429-1435","journal-title":"J Bone Joint Surg Am"},{"key":"ref=123","first-page":"101","volume":"22","author":"Gilani S.T.","year":"2012","unstructured":"Gilani S.T.; Khan D.A.; Khan F.A.; Ahmed M.; Adverse effects of low dose methotrexate in rheumatoid arthritis patients. J Coll Physicians Surg Pak 2012,22(2),101-104","journal-title":"J Coll Physicians Surg Pak"},{"key":"ref=124","first-page":"1","volume":"9","author":"Codreanu C.","year":"2015","unstructured":"Codreanu C.; Damjanov N.; Safety of biologics in rheumatoid arthritis: Data from randomized controlled trials and registries. Biologics 2015,9,1-6","journal-title":"Biologics"},{"key":"ref=125","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/ptr.6338","volume":"33","author":"Majeed M.","year":"2019","unstructured":"Majeed M.; Majeed S.; Narayanan N.K.; Nagabhushanam K.; A pilot, randomized, double\u2010blind, placebo\u2010controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res 2019,33(5),1457-1468","journal-title":"Phytother Res"},{"key":"ref=126","first-page":"293","volume":"3","author":"Majeed M.","year":"2016","unstructured":"Majeed M.; Vaidyanathan P.; Natarajan S.; Majeed S.; Vuppala K.K.; Effect of Boswellin&#xAE; Super on knee pain in Japanese adults: A randomized, double-blind, placebo-controlled trial. Eur J Biomed 2016,3,293-298","journal-title":"Eur J Biomed"},{"key":"ref=127","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019723","volume":"99","author":"Shep D.","year":"2020","unstructured":"Shep D.; Khanwelkar C.; Gade P.; Karad S.; Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis. Medicine (Baltimore) 2020,99(16)","journal-title":"Medicine (Baltimore)"},{"key":"ref=128","doi-asserted-by":"publisher","first-page":"451","DOI":"10.2147\/CIA.S58535","volume":"9","author":"Kuptniratsaikul V.","year":"2014","unstructured":"Kuptniratsaikul V.; Dajpratham P.; Taechaarpornkul W.; Buntragulpoontawee M.; Lukkanapichonchut P.; Chootip C.; Saengsuwan J.; Tantayakom K.; Laongpech S.; Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin Interv Aging 2014,9,451-458","journal-title":"Clin Interv Aging"},{"key":"ref=129","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13063-019-3327-2","volume":"20","author":"Shep D.","year":"2019","unstructured":"Shep D.; Khanwelkar C.; Gade P.; Karad S.; Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: A randomized open-label parallel-arm study. Trials 2019,20(1),214","journal-title":"Trials"},{"key":"ref=130","first-page":"385","volume":"3","author":"Delazar A.","year":"2013","unstructured":"Delazar A.; Sarker S.D.; Nahar L.; Jalali S.B.; Modaresi M.; Hamedeyazdan S.; Babaei H.; Javadzadeh Y.; Asnaashari S.; Bamdad Moghadam S.; Rhizomes of Eremostachys laciniata: Isolation and structure elucidation of chemical constituents and a clinical trial on inflammatory diseases. Adv Pharm Bull 2013,3(2),385-393","journal-title":"Adv Pharm Bull"},{"key":"ref=131","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jaim.2016.05.003","volume":"7","author":"Ramakanth G.S.H.","year":"2016","unstructured":"Ramakanth G.S.H.; Uday Kumar C.; Kishan P.V.; Usharani P.; A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med 2016,7(3),151-157","journal-title":"J Ayurveda Integr Med"},{"key":"ref=132","first-page":"3375","volume":"5","author":"Zakeri Z.","year":"2011","unstructured":"Zakeri Z.; Izadi S.; Bari Z.; Soltani F.; Narouie B.; Ghasemi-Rad M.; Evaluating the effects of ginger extract on knee pain, stiffness and difficulty in patients with knee osteoarthritis. J Med Plants Res 2011,5(15),3375-3379","journal-title":"J Med Plants Res"},{"key":"ref=133","first-page":"267","volume":"8","author":"Haghighi M.","year":"2005","unstructured":"Haghighi M.; Khalvat A.; Toliat T.; Jallaei S.H.; Comparing the effects of ginger (Zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iran Med 2005,8(4),267-271","journal-title":"Arch Iran Med"},{"key":"ref=134","first-page":"2160","volume":"28","author":"Tao X.","year":"2001","unstructured":"Tao X.; Cush J.J.; Garret M.; Lipsky P.E.; A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis. J Rheumatol 2001,28(10),2160-2167","journal-title":"J Rheumatol"},{"key":"ref=135","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00776-014-0633-0","volume":"19","author":"Nakagawa Y.","year":"2014","unstructured":"Nakagawa Y.; Mukai S.; Yamada S.; Matsuoka M.; Tarumi E.; Hashimoto T.; Tamura C.; Imaizumi A.; Nishihira J.; Nakamura T.; Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: A randomized, double-blind, placebo-controlled prospective study. J Orthop Sci 2014,19(6),933-939","journal-title":"J Orthop Sci"},{"key":"ref=136","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1002\/1529-0131(200111)44:11<2531:AID-ART433>3.0.CO;2-J","volume":"44","author":"Altman R.D.","year":"2001","unstructured":"Altman R.D.; Marcussen K.C.; Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001,44(11),2531-2538","journal-title":"Arthritis Rheum"},{"key":"ref=137","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.ctcp.2015.06.003","volume":"21","author":"Shoara R.","year":"2015","unstructured":"Shoara R.; Hashempur M.H.; Ashraf A.; Salehi A.; Dehshahri S.; Habibagahi Z.; Efficacy and safety of topical Matricaria chamomilla L. (chamomile) oil for knee osteoarthritis: A randomized controlled clinical trial. Complement Ther Clin Pract 2015,21(3),181-187","journal-title":"Complement Ther Clin Pract"},{"key":"ref=138","first-page":"27","volume":"19","author":"Pirouzpanah S.","year":"2017","unstructured":"Pirouzpanah S.; Mahboob S.; Sanayei M.; Hajaliloo M.; Safaeiyan A.; The effect of chamomile tea consumption on inflammation among rheumatoid arthritis patients: Randomized clinical trial. Prog Nutr 2017,19,27-33","journal-title":"Prog Nutr"},{"key":"ref=139","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.intimp.2012.06.001","volume":"14","author":"Zhang W.","year":"2012","unstructured":"Zhang W.; Dai S.M.; Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol 2012,14(1),27-31","journal-title":"Int Immunopharmacol"},{"key":"ref=140","first-page":"5198","volume":"20","author":"Bolognesi G.","year":"2016","unstructured":"Bolognesi G.; Belcaro G.; Feragalli B.; Cornelli U.; Cotellese R.; Hu S.; Dugall M.; Movardol&#xAE; (N-acetylglucosamine, Boswellia serrata, ginger) supplementation in the management of knee osteoarthritis: Preliminary results from a 6-month registry study. Eur Rev Med Pharmacol Sci 2016,20(24),5198-5204","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref=141","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s12038-007-0030-3","volume":"32","author":"Sumantran V.N.","year":"2007","unstructured":"Sumantran V.N.; Kulkarni A.; Boddul S.; Chinchwade T.; Koppikar S.J.; Harsulkar A.; Patwardhan B.; Chopra A.; Wagh U.V.; Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis. J Biosci 2007,32(2),299-307","journal-title":"J Biosci"},{"key":"ref=142","doi-asserted-by":"publisher","DOI":"10.17795\/jjcdc-34798","volume":"6","author":"Alipour Z.","year":"2016","unstructured":"Alipour Z.; Asadizaker M.; Fayazi S.; Yegane N.; Kochak M.; Haghighi Zadeh M.H.; The effect of ginger on pain and satisfaction of patients with knee osteoarthritis. Jundishapur J Chron Dis Care 2016,6(1)","journal-title":"Jundishapur J Chron Dis Care"},{"key":"ref=143","first-page":"447","volume":"100","author":"Amorndoljai P.","year":"2017","unstructured":"Amorndoljai P.; Taneepanichskul S.; Niempoog S.; Nimmannit U.; A comparative of ginger extract in Nanostructure Lipid Carrier (NLC) and 1% diclofenac gel for treatment of knee osteoarthritis (OA). J Med Assoc Thai 2017,100(4),447-456","journal-title":"J Med Assoc Thai"},{"key":"ref=144","first-page":"121","volume":"10","author":"Amorndoljai P.","year":"2015","unstructured":"Amorndoljai P.; Taneepanichskul S.; Niempoog S.; Nimmannit U.; A clinical study phase II of ginger extract in nanostructured lipid carrier for pain relief in knee osteoarthritis patients. Isan J Pharm Sci 2015,10,121-132","journal-title":"Isan J Pharm Sci"},{"key":"ref=145","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12906-017-2062-z","volume":"18","author":"Haroyan A.","year":"2018","unstructured":"Haroyan A.; Mukuchyan V.; Mkrtchyan N.; Minasyan N.; Gasparyan S.; Sargsyan A.; Narimanyan M.; Hovhannisyan A.; Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med 2018,18(1),7","journal-title":"BMC Complement Altern Med"},{"key":"ref=146","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s12906-017-1957-z","volume":"17","author":"Jiang Q.","year":"2017","unstructured":"Jiang Q.; Tang X.P.; Chen X.C.; Xiao H.; Liu P.; Jiao J.; Will Chinese external therapy with compound Tripterygium wilfordii hook F gel safely control disease activity in patients with rheumatoid arthritis: Design of a double-blinded randomized controlled trial. BMC Complement Altern Med 2017,17(1),444","journal-title":"BMC Complement Altern Med"},{"key":"ref=147","doi-asserted-by":"publisher","first-page":"46","DOI":"10.12998\/wjcc.v8.i1.46","volume":"8","author":"Hu C.X.","year":"2020","unstructured":"Hu C.X.; Hu K.Y.; Wang J.F.; Potential role of the compound Eucommia bone tonic granules in patients with osteoarthritis and osteonecrosis: A retrospective study. World J Clin Cases 2020,8(1),46-53","journal-title":"World J Clin Cases"},{"key":"ref=148","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1177\/0394632015622215","volume":"29","author":"Notarnicola A.","year":"2016","unstructured":"Notarnicola A.; Maccagnano G.; Moretti L.; Pesce V.; Tafuri S.; Fiore A.; Moretti B.; Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritis: Randomized trial. Int J Immunopathol Pharmacol 2016,29(1),140-146","journal-title":"Int J Immunopathol Pharmacol"}],"container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1567201819666220901092832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/208398\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1567201819666220901092832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T14:56:22Z","timestamp":1701010582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/208398\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":148,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201819666220901092832","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2022-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}