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However, Nys is a class IV drug according to the Biopharmaceutical Classification System, that possesses limited bioavailability, and is used for local activity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study developed and characterized nystatin:\u03b2-cyclodextrin (Nys:\u03b2CD) inclusion complexes and evaluated their activity against Candida spp.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Complexes were characterized by physicochemical techniques and drug dissolution profiles. The susceptibility of C. albicans, C. krusei, C. parapsilosis, C. glabrata, C. guilliermondii, C. tropicalis, and C. auris was assessed using the broth microdilution method. The applicability of Nys:\u03b2CD inclusion complex was evaluated by incorporating it into a temporary soft material for denture stomatitis treatment<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Nys was better complexed in a 1:1 molar ratio by freeze-drying and spray-drying methods. The inclusion complexes show bi-exponential release, an initial burst release followed by a sustained manner, presenting higher dissolution efficiency than raw Nys. The 1:1 freeze-drying Nys:\u03b2CD complex presents antifungal activity against all evaluated Candida strains, showing the maintenance of the drug effectiveness. The inclusion complex incorporated into a tissue conditioner material for denture stomatitis treatment effectively inhibited more than 90% of C. albicans biofilm growth during 7 and 14 days, in a half dose compared to raw Nys.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>This work represents a significant contribution to treating a wide variety of diseases caused by the Candida species, optimizing the drug bioavailability and compliance to the treatment due to improved drug solubility, dissolution, and sustained delivery.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201820666221017103119","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T06:45:45Z","timestamp":1666248345000},"page":"1533-1546","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization, Antifungal Evaluation against Candida spp. Strains and\nApplication of Nystatin: \u03b2-cyclodextrin Inclusion Complexes"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-1603","authenticated-orcid":true,"given":"Amanda Migliorini","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine Sumie","family":"Morikava","sequence":"additional","affiliation":[{"name":"Department of\nDentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-4913","authenticated-orcid":true,"given":"Amanda Cristina","family":"Schoeffel","sequence":"additional","affiliation":[{"name":"Department of\nDentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-6285","authenticated-orcid":true,"given":"Andressa","family":"Novatski","sequence":"additional","affiliation":[{"name":"Department of Physics, State University of Ponta\nGrossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0777-5012","authenticated-orcid":true,"given":"Gustavo Sim\u00e3o","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of\nDentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-9055","authenticated-orcid":true,"given":"Victoria Schlumberger","family":"Cachoeira","sequence":"additional","affiliation":[{"name":"Department of\nDentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciette","family":"Matioli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Maringa, Maringa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-1508","authenticated-orcid":true,"given":"Carmen Antonia","family":"Sanches Ito","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Analyses, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-6646","authenticated-orcid":true,"given":"Priscileila Colerato","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-2667","authenticated-orcid":true,"given":"Karin Hermana","family":"Neppelenbroek","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics\nand Periodontics, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3320-8783","authenticated-orcid":true,"given":"Vanessa Migliorini","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of\nDentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9934-4027","authenticated-orcid":true,"given":"Paulo Vitor","family":"Farago","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3390\/ijms17101643","volume":"17","author":"Chin V.","year":"2016","unstructured":"Chin V.; 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