{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:56:15Z","timestamp":1776664575483,"version":"3.51.2"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"\n Background:<\/jats:title>\n This study aimed to improve the sustained and controlled release of glycyrrhizic\nacid to the infected site of Staphylococcus aureus small colony variants (SCVs).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The glycyrrhizic acid-loaded chitosan composite nanogel was prepared by inclusion action,\nSchiff\u2019s base formation, and electrostatic action. Furthermore, the formulation screening, characteristics,\nin vitro release, and antibacterial activity of the glycyrrhizic acid composite nanogel were explored.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The final optimal formula comprised 10 mg\/mL (chitosan) and 50 \u03bcL (glutaraldehyde). The\nloading capacity, encapsulation efficiency, mean size, polydispersity index, and zeta potential were\n8.8%\u00b11.6%, 92.1%\u00b12.8%, 478.3\u00b12.8 nm, 0.37\u00b10.10, and 25.3\u00b13.6 mv, respectively. Scanning electron\nmicroscope images showed a spherical shape with a relatively uniform distribution. The in vitro release\nstudy showed that glycyrrhizic acid composite nanogel exhibited a biphasic pattern with a sustained\nrelease of 52.1%\u00b12.0% at 48 h in the pH 5.5 PBS. The minimum inhibitory and minimum biofilm inhibitory\nconcentrations of glycyrrhizic acid composite nanogel against SCVs were 0.625 \u03bcg\/mL. The\ntime-killing curves and live\/dead bacterial staining showed that glycyrrhizic acid composite nanogel\nhad a stronger curative effect against SCVs strain with concentration-dependent.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This study provides promising glycyrrhizic acid composite nanogel to improve the treatment\nof SCV infection.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/1567201820666230117150253","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T23:52:10Z","timestamp":1673999530000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibacterial Activity of a Novel Glycyrrhizic Acid-loaded Chitosan Composite Nanogel In vitro Against Staphylococcus Aureus Small Colony Variants"],"prefix":"10.2174","volume":"23","author":[{"given":"Mujie","family":"Ju","sequence":"first","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang, 843300, China"},{"name":"Key Laboratory of Tarim Animal Husbandry & Science Technology of Xinjiang Production & Construction Corps., Alar, Xinjiang 843300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang, 843300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Guan","sequence":"additional","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang, 843300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nannan","family":"Leng","sequence":"additional","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang, 843300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah Attia","family":"Algharib","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, QG, Egypt"},{"name":"National Reference Laboratory of Veterinary Drug Residues (HZAU) and MARA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Sobhy","family":"Dawood","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, 32897, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanhe","family":"Luo","sequence":"additional","affiliation":[{"name":"Engineering Laboratory for Tarim Animal Diseases Diagnosis and Control, College of Animal Science, Tarim University, Alar, Xinjiang, 843300, China"},{"name":"Key Laboratory of Tarim Animal Husbandry & Science Technology of Xinjiang Production & Construction Corps., Alar, Xinjiang 843300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1567201820666230117150253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/212822\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1567201820666230117150253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:28:25Z","timestamp":1776662905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/212822\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567201820666230117150253","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,7]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2022-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}