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The high surface area, pore volume, and accessible\nLewis acid sites make MIL-100 (Fe) a proper candidate for hydrophobic anticancer drug loading\nand storage. In this study, a novel investigation of cyclophosphamide (CP) -loaded MIL-100(Fe) (MIL-\n100(Fe)\/CP) and a simulation of drug loading at a molecular level is presented.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>This research used a facile synthesis method to prepare MIL-100(Fe), which addresses the\nhigh temperature and pressure challenges of synthesis methods. MIL-100(Fe) and MIL-100(Fe)\/CP\nwere characterized using x-ray diffraction (XRD), Brunauer\u2013Emmett\u2013Teller (BET), Fourier transform\ninfrared (FTIR), and field emission scanning electron microscopy (FESEM).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The carriers' drug loading and release behavior are determined by using UV-visible spectrophotometry.\nThe 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay is applied\nto examine the biocompatibility and the anticancer effect of MIL-100(Fe)\/CP on the human breast cancer\ncell line (MCF-7).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In vivo antitumor experiments and histological observation reveal inhibition properties of\nMIL-100(Fe)\/CP on the tumor cells. MIL-100(Fe)\/CP, with 37.41% drug payload, represents impressive\nantitumor activity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567201820666230410120437","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T03:35:05Z","timestamp":1681356905000},"page":"283-294","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cyclophosphamide Loading and Controlled Release in MIL-100(Fe) as an\nAnti-breast Cancer Carrier: In vivo In vitro Study"],"prefix":"10.2174","volume":"21","author":[{"given":"Shabnam","family":"Tohidi","sequence":"first","affiliation":[{"name":"Faculty of Materials Science and Engineering, KN Toosi University of Technology, Tehran, 1999143344, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-1451","authenticated-orcid":true,"given":"Mehrdad","family":"Aghaie-Khafri","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, KN Toosi University of Technology, Tehran, 1999143344, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"1","volume":"57","author":"Heron M.","year":"2009","unstructured":"Heron M.; National vital statistics reports. 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