{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:57:54Z","timestamp":1792821474971,"version":"4.5.0"},"reference-count":24,"publisher":"Bentham Science Publishers Ltd.","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771258"],"award-info":[{"award-number":["81771258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNR"],"published-print":{"date-parts":[[2020,9,29]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Hemiplegia is a common symptom after acute cerebral infarction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aimed to explore the influence factors of gait performance and investigate\nwhether donepezil could improve gait performance in patients with an acute cerebral infarction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A total of 107 patients who experienced unilateral paresis after an acute cerebral infarction\nincident were enrolled in this prospectively observational study. Participants underwent a 3-\nmonth assessment. At the study's conclusion, patients were divided into 2 groups-those who received\ndonepezil daily (observation Group) and those who did not (Control Group).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>There was a significant difference (t=3.269, P=0.001) of Wisconsin Gait Scale (WGS)\nscore between single site infarction (27.11\u00b16.65) and multiple sites infarction (31.54\u00b16.42). For\ngender, smoking, drinking, hypertension, hyperlipidemia and diabetes, there was no difference in\nWGS scores between subgroups (P&gt;0.05), respectively. The patient's admission National Institute\nof Health Stroke Scale(NIHSS) score had a strongly positive correlation with WGS score (r=0.850,\nP&lt;0.001). Besides, age (r=0.218, P=0.024), glycosylated hemoglobin (r=0.274, P=0.004), MMSE\n(r=-0.261, P=0.007) and Montreal Cognitive Assessment (MoCA) (r=-0.272, P=0.005) had a weak\ncorrelation with WGS scores. Multivariate analysis showed age (95% CI: 0.042~0.188, P=0.002),\nadmission NIHSS score (95% CI: 2.405~3.137, P&lt;0.001) and multiple sites infarction (95% CI:\n0.044~2.983, P=0.044) were independent risk factors of WGS scores. WGS scores of both observation\nand control groups gradually decreased after admission (P&lt;0.001). At 3 months after admission,\nWGS score of the observation group was significantly lower than the control group\n(t=2.468, P=0.015). There were no significant differences between observation and control group\nat admission and 1 month after admission (P&gt;0.05) and WGS scores of both single site and multiple\nsites infarction gradually decreased at one month and three months after admission (P&lt;0.001),\nwhile there was no significant difference between two groups (P&gt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Admission NIHSS score, age and multiple sites infarction were independent risk factors\nof WGS score. Donepezil could improve gait performance in patients with acute cerebral infarction.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567202617666200413130101","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T18:53:31Z","timestamp":1586804011000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Donepezil Improves Gait Performance in Patients with an Acute Cerebral Infarction: A Prospective Observational Cohort Study"],"prefix":"10.2174","volume":"17","author":[{"given":"Ying-Ying","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Tongji University School of Medicine, Shanghai Tenth People\u2019s Hospital, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji University School of Medicine, Shanghai Tenth People\u2019s Hospital, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji University School of Medicine, Shanghai Tenth People\u2019s Hospital, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-7551","authenticated-orcid":true,"given":"Yan-Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji University School of Medicine, Shanghai Tenth People\u2019s Hospital, 301 Middle Yanchang Road, Shanghai 200072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ya","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tongji University School of Medicine, East Hospital, 150 Jimo Road, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000441085","volume":"45","author":"Feigin V.L.","year":"2015","unstructured":"Feigin V.L.; Krishnamurthi R.V.; Parmar P.; GBD 2013 Stroke Panel Experts Group. 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