{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:33:13Z","timestamp":1777534393301,"version":"3.51.4"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNR"],"published-print":{"date-parts":[[2021,2,22]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Haptoglobin (Hp) binds to and facilitates clearance of heme. Compared\nwith HP 1-1 and 1-2 genotypes, HP 2-2 has a weaker binding affinity and has been linked with increased\ninflammation and vasospasm after aneurysmal subarachnoid hemorrhage (SAH).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This study aims to assess levels of inflammatory cytokines in the context of different\nHP genotypes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Patients were enrolled among those presenting with spontaneous aneurysmal SAH.\nBlood was drawn at four time points; &lt;24 hours (T1), 24-48 hours (T2), 3-5 days (T3), and 6-8\ndays (T4). Blood was analyzed for levels of 41 cytokines at each time point, as well as for HP genotypes.\nThese data were analyzed using mixed-effect models to assess the association between HP\ngenotypes and cytokine levels. The modified Rankin Scale (mRS) score was obtained at discharge,\n3 months, and 6 months.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Fifty-seven patients were enrolled. Compared with HP 1-1 and 1-2, subjects encoding HP\n2-2 had elevated levels of the following cytokines at all time points: FLT3L, IFN\u03b3, IL-17A, TGF\u03b1,\nand VEGF-A. Elevations were also seen at some time points for IL-8, CSF2, FGF2, IL-7,\nIL-12p70, and TNF\u03b3. This study was not powered to detect differences in the functional outcome;\nhowever, there were no significant differences in dichotomized mRS scores between patients with\nHP 1-1\/1-2 or HP 2-2.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our findings indicate that HP 2-2 genotype leads to increased proinflammatory cytokine\nlevels compared with HP 1-1\/1-2 genotypes. These data may provide guidance for further\nstudies seeking to identify testable markers for functional prognosis or targets for treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567202617666201214104623","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T11:02:07Z","timestamp":1608030127000},"page":"652-659","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Haptoglobin Genotype Affects Inflammation after Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.2174","volume":"17","author":[{"given":"Aaron M.","family":"Gusdon","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jude","family":"Savarraj","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peeyush K. Thankamani","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3771-5109","authenticated-orcid":true,"given":"Sylvain","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin W.","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HuiMahn A.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spiros L.","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, McGovern Medicine School, University of Texas Health Science Center at Houston, Houston, TX, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Neurovascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/189107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189107\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/189107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T04:46:55Z","timestamp":1614055615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189107\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,2,22]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567202617666201214104623","relation":{},"ISSN":["1567-2026"],"issn-type":[{"value":"1567-2026","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}