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The associations of 40 SNPs and environmental\npredictors with MCI-AD progression were assessed using the Kaplan-Meier method with the\nlog-rank test and Cox regression model.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Rs4147929 at ATP-binding cassette family A member 7 (ABCA7) (AG\/AA vs. GG, hazard ratio\n[HR] = 2.43, 95% confidence interval [CI] 1.24-4.76) and body mass index (BMI) (overweight vs.\nnon-overweight, HR = 0.41, 95% CI 0.22-0.78) were independent predictors of MCI-AD progression. In\nthe combined analyses, MCI participants with the copresence of non-overweight BMI and the ABCA7\nrs4147929 (AG\/AA) risk genotype had an approximately 6-fold higher risk of MCI-AD progression\nthan those with an overweight BMI and a non-risk genotype (HR = 6.77, 95% CI 2.60-17.63). However,\na nonsignificant result was found when participants carried only one of these two risk factors (nonoverweight\nBMI and AG\/AA of ABCA7 rs4147929).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>ABCA7 rs4147929 and BMI jointly affect MCI-AD progression. MCI participants with the\nrs4147929 risk genotype may benefit from maintaining an overweight BMI level with regard to their\nrisk for incident AD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666200317095608","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T14:24:41Z","timestamp":1584455081000},"page":"185-195","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Joint Effect of ABCA7 rs4147929 and Body Mass Index on Progression from Mild Cognitive Impairment to Alzheimer\u2019s Disease: The Shanghai Aging Study"],"prefix":"10.2174","volume":"17","author":[{"given":"Jianxiong","family":"Xi","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Health Education, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoniu","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihao","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Health Education, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Health Education, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianyi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Health Education, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"author":"Burns A","key":"ref=1","unstructured":"Burns A; Iliffe S.;  Dementia BMJ: b75 2009."},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"Querfurth H.W.","unstructured":"Querfurth H.W.; LaFerla F.M.; Alzheimer\u2019s disease. 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