{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:13:16Z","timestamp":1790950396967,"version":"4.1.0"},"reference-count":33,"publisher":"Bentham Science Publishers Ltd.","issue":"2","funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105-2314- B-038-021"],"award-info":[{"award-number":["MOST 105-2314- B-038-021"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAR"],"published-print":{"date-parts":[[2020,4,25]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>In addition to the traditional risk predictors, whether anemia is an early biomarker\nof dementia, needs to be confirmed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This population-based cohort study aimed to investigate the dementia risk in patients with\nnewly diagnosed anemia using data from the Taiwan National Health Insurance Research Database.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>All newly diagnosed anemia patients (n = 26,343) with no history of stroke hospitalization,\ncentral nervous disease other than dementia, psychiatric disorders, traumatic brain injury, major operations,\nor blood loss diseases, were enrolled. A group of non-anemic controls, 1:4 matched with anemic\npatients on the basis of demographics and comorbidities, was also included. A competing risk analysis\nwas used to evaluate the dementia risk in anemic patients compared to that of their matched controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The adjusted subdistribution hazard ratio (SHR) of dementia risk in anemic patients was 1.14\n(95% confidence interval [CI]: 1.08~1.21, p&lt;0.001). Patients with iron supplements tended to exhibit a\nlower dementia risk (adjusted SHR: 0.84; 95% CI: 0.75~0.94, p=0.002) compared to patients without\niron supplement. A subgroup analysis showed that a positive association between dementia and anemia\nexisted in females, those aged 70 years and older, and patients without hypertension, diabetes, or hyperlipidemia.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The present population-based cohort study identified that newly diagnosed anemia is a risk\nfactor for dementia and also that iron supplementation was able to reduce the risk of dementia in people\nwith iron deficiency anemia.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666200317101516","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T14:24:41Z","timestamp":1584455081000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Anemia and Dementia: A Nationwide, Populationbased Cohort Study in Taiwan"],"prefix":"10.2174","volume":"17","author":[{"given":"Chien-Tai","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Health and Clinical Research Data Center, School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yi","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Applied Molecular Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Nien","family":"Chien","sequence":"additional","affiliation":[{"name":"School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13195-016-0188-8","volume":"8","author":"Prince M.","unstructured":"Prince M.; Ali G.C.; Guerchet M.; Prina A.M.; Albanese E.; Wu Y.T.; Recent global trends in the prevalence and incidence of dementia, and survival with dementia. 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