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Therefore, the correlation between ALDH2 Glu504Lys polymorphism and LOAD remains\ncontroversial. To analyze the correlation between ALDH2 polymorphism and the risk of LOAD, we implemented\nthis up-to-date meta-analysis to assess the probable association.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Studies were searched through China National Knowledge Infrastructure (CNKI), VIP Database\nfor Chinese Technical Periodicals, China Biology Medicine, PubMed, Cochrane Library, Clinical-\nTrials.gov, Embase, and MEDLINE from January 1, 1994 to December 31, 2018, without any restrictions\non language and ethnicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Five studies of 1057 LOAD patients and 1136 healthy controls met our criteria for the analysis.\nStatistically, the ALDH2 GA\/AA genotype was not linked with raising LOAD risk (odds ratio (OR) =\n1.48, 95% confidence interval (CI) = 0.96-2.28, p = 0.07). In subgroup analysis, the phenomenon that\nmen with ALDH2*2 had higher risk for LOAD (OR = 1.72, 95%CI = 1.10-2.67, p = 0.02) was observed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions:<\/jats:title>\n<jats:p>This study comprehends only five existing case-control studies and the result is negative.\nThe positive trend might appear when the sample size is enlarged. In the future, more large-scale casecontrol\nor cohort studies should be done to enhance the association between ALDH2 polymorphism and\nAD or other neurodegenerative diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666200317102337","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T14:24:41Z","timestamp":1584455081000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between ALDH2 Gene Polymorphism and Late-onset Alzheimer Disease: An Up-to-date Meta-analysis"],"prefix":"10.2174","volume":"17","author":[{"given":"Haitao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Practice, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of General Practice, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Practice, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of General Practice, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Military Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/23808993.2017.1286227","volume":"2","author":"Chiba-Falek O.","unstructured":"Chiba-Falek O.; Lutz M.W.; Towards precision medicine in Alzheimer\u2019s disease: deciphering genetic data to establish informative biomarkers. 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