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Ca2+ dysregulation, specifically abnormal release of Ca2+ via over activated ryanodine receptor\n(RyR), has been increasingly considered as an alternative upstream mechanism in AD pathology. Consequently,\ndantrolene, a RyR antagonist and FDA approved drug to treat malignant hyperthermia and\nchronic muscle spasms, has been shown to ameliorate memory loss in AD transgenic mice. However,\nthe inefficiency of dantrolene to pass the Blood Brain Barrier (BBB) and penetrate the Central Nervous\nSystem needs to be resolved, considering its dose-dependent neuroprotection in AD and other neurodegenerative\ndiseases. In this mini-review, we will discuss the current status of dantrolene neuroprotection\nin AD treatment and a strategy to maximize its beneficial effects, such as intranasal administration\nof dantrolene.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666200522204722","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T17:46:16Z","timestamp":1590169576000},"page":"324-328","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease"],"prefix":"10.2174","volume":"17","author":[{"given":"Matan B.","family":"Abou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","unstructured":"Rapid growth in neuroscience research: A study of neuroscience papers from 2006-2015 has revealed the most productive journals and contributing countries, and the most popular research topics [Internet]ScienceDaily 2019[cited 23 June 2019] Available from","journal-title":"Rapid growth in neuroscience research: A study of neuroscience papers from 2006-2015 has revealed the most productive journals and contributing countries, and the most popular research topics [Internet]ScienceDaily 2019[cited 23 June 2019] Available from"},{"key":"ref=2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/B978-0-12-384860-4.00011-3","author":"Stocum D.","year":"2012","unstructured":"Stocum D.; Regenerative medicine of neural tissues. 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