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Most of the recent AD clinical trials were targeting amyloid pathway, but\nall these trials failed. Although amyloid pathology is a hallmark and defining feature of AD, targeting\nthe amyloid pathway has been very challenging due to low efficacy and serious side effects. Alternative\napproaches or mechanisms for our understanding of the major cause of memory loss in AD need to be\nconsidered as potential therapeutic targets. Increasing studies suggest that Ca2+ dysregulation in AD\nplays an important role in AD pathology and is associated with other AD abnormalities, such as excessive\ninflammation, increased ROS, impaired autophagy, neurodegeneration, synapse, and cognitive dysfunction.\nCa2+ dysregulation in cytosolic space, Endoplasmic Reticulum (ER) and mitochondria have\nbeen reported in the context of various AD models. Drugs or strategies, to correct the Ca2+ dysregulation\nin AD, have been demonstrated to be promising as an approach for the treatment of AD in preclinical\nmodels. This review will discuss the mechanisms of Ca2+ dysregulation in AD and associated pathology\nand discuss potential approaches or strategies to develop novel drugs for the treatment of AD by targeting\nCa2+ dysregulation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666200528162046","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T19:24:34Z","timestamp":1590780274000},"page":"344-354","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Reversal of Calcium Dysregulation as Potential Approach for Treating Alzheimer's Disease"],"prefix":"10.2174","volume":"17","author":[{"given":"Elena","family":"Popugaeva","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Chernyuk","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Bezprozvanny","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration, Peter the Great St Petersburg Polytechnic University, St Petersburg, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"Braak H.","year":"1991","unstructured":"Braak H.; Braak E.; Neuropathological stageing of Alzheimer-related changes. 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