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Pre-clinically, streptozotocin (3mg\/kg, 10\u03bcl\/\nunilateral, ICV) stereotaxically mimics the behavioral and neurochemical alterations similar to Alzheimer's\ntau pathology resulting in MT assembly defects further lead to neuropathological cascades.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Clinically approved medications such as Donepezil (DNP), rivastigmine, and Memantine\n(MEM) are responsible for symptomatic care only, but there is no specific pharmacological intervention\nthat directly interacts with the neuronal microtubule destabilization.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The current study focused on the involvement of anti-cancer agent microtubule stabilizer cabazitaxel\nat a low dose (0.5 and 2 mg\/kg) alone and in combination with standard drugs DNP (5 mg\/kg),\nMEM (10 mg\/kg) and microtubule stabilizer Epothilone D (EpoD) (3 mg\/kg) in the prevention of intracerebroventricular\nstreptozotocin (ICV-STZ) intoxicated microtubule-associated tau protein hyperphosphorylation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> Chronic treatment of CBZ at a low dose alone and in combination with standard drugs showing\nno side effect and significantly improve the cognitive impairment, neurochemical alterations along with\nreducing the level of hyperphosphorylated tau by preventing the breakdown of the neuronal cytoskeleton,\nrespectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The above findings suggested that CBZ at low dose show neuroprotective effects against\nICV-STZ induced microtubule-associated tau protein hyperphosphorylation in rats and may be an effective\nagent for the preventive treatment of AD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666201007120112","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:18:43Z","timestamp":1602148723000},"page":"601-615","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Investigation of Low Dose Cabazitaxel Potential as Microtubule Stabilizer in Experimental Model of Alzheimer's Disease: Restoring Neuronal Cytoskeleton"],"prefix":"10.2174","volume":"17","author":[{"given":"Pallavi","family":"Duggal","sequence":"first","affiliation":[{"name":"Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep S.","family":"Jadaun","sequence":"additional","affiliation":[{"name":"Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehraz M.","family":"Siqqiqui","sequence":"additional","affiliation":[{"name":"Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth","family":"Mehan","sequence":"additional","affiliation":[{"name":"Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.4172\/2161-0460.1000208","volume":"6","author":"Singh A.","year":"2016","unstructured":"Singh A.; Kumar A.; Comparative analysis of intrahippocampal amyloid beta (1\u201342) and it is intracerebroventricularstreptozotocin models of Alzheimer\u2019s disease: Possible behavioral, biochemical, mitochondrial, cellular and histopathological evidences. 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