{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:55:48Z","timestamp":1777532148789,"version":"3.51.4"},"reference-count":75,"publisher":"Bentham Science Publishers Ltd.","issue":"8","funder":[{"DOI":"10.13039\/501100012156","name":"Shenzhen Basic Research","doi-asserted-by":"publisher","award":["JCYJ20170815153617033"],"award-info":[{"award-number":["JCYJ20170815153617033"]}],"id":[{"id":"10.13039\/501100012156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012156","name":"Shenzhen Basic Research","doi-asserted-by":"publisher","award":["JCYJ201805071-82657867"],"award-info":[{"award-number":["JCYJ201805071-82657867"]}],"id":[{"id":"10.13039\/501100012156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAR"],"published-print":{"date-parts":[[2020,12,24]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>Circular RNAs (circRNAs) are a kind of non-coding RNA molecule with highly stable circular\nstructures. CircRNAs are primarily composed of exons and\/or introns. Recently, a lot of exciting\nstudies showed that circRNA played an essential role in the development of nervous system diseases.\nHere, classification, characteristics, biogenesis, and the association of circRNA dysregulation with nervous\nsystem diseases, such as Alzheimer\u2019s disease, are summarized. The review not only contributes to a\nbetter understanding of circRNAs, but also provides new research directions toward the diagnosis, treatment,\nand prevention of nervous system diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1567205017666201111114928","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T05:18:46Z","timestamp":1605158326000},"page":"687-697","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Research Progress on circRNA in Nervous System Diseases"],"prefix":"10.2174","volume":"17","author":[{"given":"Nana","family":"Ma","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature11247","volume":"489","year":"2012","unstructured":"An integrated encyclopedia of DNA elements in the human genome. Nature 2012,489(7414),57-74","journal-title":"Nature"},{"key":"ref=2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41580-019-0146-y","volume":"7","author":"Zlotorynski E.","year":"2019","unstructured":"Zlotorynski E.; The innate function of circular RNAs. Nat Rev Mol Cell Biol 2019,7,387","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref=3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"11","author":"Kristensen L.S.","year":"2019","unstructured":"Kristensen L.S.; Andersen M.S.; Stagsted L.V.W.; Ebbesen K.K.; Hansen T.B.; Kjems J.; The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet 2019,11,675-691","journal-title":"Nat Rev Genet"},{"key":"ref=4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41577-019-0173-0","volume":"6","author":"Flemming A.","year":"2019","unstructured":"Flemming A.; The enigma of circular RNA. Nat Rev Immunol 2019,6,351","journal-title":"Nat Rev Immunol"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12943-019-1121-0","volume":"1","author":"Sun J.","year":"2020","unstructured":"Sun J.; Li B.; Shu C.; Ma Q.; Wang J.; Functions and clinical significance of circular RNAs in glioma. Mol Cancer 2020,1,34","journal-title":"Mol Cancer"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"Memczak S.","year":"2013","unstructured":"Memczak S.; Jens M.; Elefsinioti A.; Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013,495(7441),333-338","journal-title":"Nature"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1261\/rna.035667.112","volume":"19","author":"Jeck W.R.","year":"2013","unstructured":"Jeck W.R.; Sorrentino J.A.; Wang K.; Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 2013,19(2),141-157","journal-title":"RNA"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1373\/clinchem.2014.230433","volume":"61","author":"Bahn J.H.","year":"2015","unstructured":"Bahn J.H.; Zhang Q.; Li F.; The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem 2015,61(1),221-230","journal-title":"Clin Chem"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2890","volume":"32","author":"Jeck W.R.","year":"2014","unstructured":"Jeck W.R.; Sharpless N.E.; Detecting and characterizing circular RNAs. Nat Biotechnol 2014,32(5),453-461","journal-title":"Nat Biotechnol"},{"key":"ref=10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003777","volume":"9","author":"Salzman J.","year":"2013","unstructured":"Salzman J.; Chen R.E.; Olsen M.N.; Wang P.L.; Brown P.O.; Cell-type specific features of circular RNA expression. PLoS Genet 2013,9(9)","journal-title":"PLoS Genet"},{"key":"ref=11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030733","volume":"7","author":"Salzman J.","year":"2012","unstructured":"Salzman J.; Gawad C.; Wang P.L.; Lacayo N.; Brown P.O.; Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One 2012,7(2)","journal-title":"PLoS One"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"11215","DOI":"10.1038\/ncomms11215","volume":"7","author":"Zheng Q.","year":"2016","unstructured":"Zheng Q.; Bao C.; Guo W.; Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun 2016,7,11215","journal-title":"Nat Commun"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"Hansen T.B.","year":"2013","unstructured":"Hansen T.B.; Jensen T.I.; Clausen B.H.; Natural RNA circles function as efficient microRNA sponges. Nature 2013,495(7441),384-388","journal-title":"Nature"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.1038\/emboj.2011.359","volume":"30","author":"Hansen T.B.","year":"2011","unstructured":"Hansen T.B.; Wiklund E.D.; Bramsen J.B.; miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J 2011,30(21),4414-4422","journal-title":"EMBO J"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/15476286.2015.1122162","volume":"14","author":"Zhao Z.J.","year":"2017","unstructured":"Zhao Z.J.; Shen J.; Circular RNA participates in the carcinogenesis and the malignant behavior of cancer. RNA Biol 2017,14(5),514-521","journal-title":"RNA Biol"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"10368","DOI":"10.1093\/nar\/gkaa704","volume":"48","author":"Ho-Xuan H.","year":"2020","unstructured":"Ho-Xuan H.; Gla\u017ear P.; Latini C.; Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts. Nucleic Acids Res 2020,48(18),10368-10382","journal-title":"Nucleic Acids Res"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/hmg\/8.3.493","volume":"8","author":"Surono A.","year":"1999","unstructured":"Surono A.; Takeshima Y.; Wibawa T.; Ikezawa M.; Nonaka I.; Matsuo M.; Circular dystrophin RNAs consisting of exons that were skipped by alternative splicing. Hum Mol Genet 1999,8(3),493-500","journal-title":"Hum Mol Genet"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"16435","DOI":"10.1038\/srep16435","volume":"5","author":"Abe N.","year":"2015","unstructured":"Abe N.; Matsumoto K.; Nishihara M.; Rolling circle translation of circular RNA in living human cells. Sci Rep 2015,5,16435","journal-title":"Sci Rep"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/wrna.1129","volume":"3","author":"Thompson S.R.","year":"2012","unstructured":"Thompson S.R.; So you want to know if your message has an IRES? Wiley Interdiscip Rev RNA 2012,3(5),697-705","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nsmb0217-194a","volume":"24","author":"Li Z.","year":"2017","unstructured":"Li Z.; Huang C.; Bao C.; Corrigendum: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol 2017,24(2),194","journal-title":"Nat Struct Mol Biol"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.molcel.2014.08.019","volume":"56","author":"Ashwal-Fluss R.","year":"2014","unstructured":"Ashwal-Fluss R.; Meyer M.; Pamudurti N.R.; circRNA biogenesis competes with pre-mRNA splicing. Mol Cell 2014,56(1),55-66","journal-title":"Mol Cell"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.molcel.2013.08.017","volume":"51","author":"Zhang Y.","year":"2013","unstructured":"Zhang Y.; Zhang X.O.; Chen T.; Circular intronic long noncoding RNAs. Mol Cell 2013,51(6),792-806","journal-title":"Mol Cell"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.molcel.2012.07.033","volume":"48","author":"Yin Q.F.","year":"2012","unstructured":"Yin Q.F.; Yang L.; Zhang Y.; Long noncoding RNAs with snoRNA ends. Mol Cell 2012,48(2),219-230","journal-title":"Mol Cell"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1261\/rna.048272.114","volume":"21","author":"Wang Y.","year":"2015","unstructured":"Wang Y.; Wang Z.; Efficient backsplicing produces translatable circular mRNAs. RNA 2015,21(2),172-179","journal-title":"RNA"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/cr.2017.31","volume":"27","author":"Yang Y.","year":"2017","unstructured":"Yang Y.; Fan X.; Mao M.; Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res 2017,27(5),626-641","journal-title":"Cell Res"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","volume":"58","author":"Rybak-Wolf A.","year":"2015","unstructured":"Rybak-Wolf A.; Stottmeister C.; Gla\u017ear P.; Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell 2015,58(5),870-885","journal-title":"Mol Cell"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nn.3975","volume":"18","author":"You X.","year":"2015","unstructured":"You X.; Vlatkovic I.; Babic A.; Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci 2015,18(4),603-610","journal-title":"Nat Neurosci"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s13059-015-0801-3","volume":"16","author":"Ven\u00f8 M.T.","year":"2015","unstructured":"Ven\u00f8 M.T.; Hansen T.B.; Ven\u00f8 S.T.; Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Genome Biol 2015,16,245","journal-title":"Genome Biol"},{"key":"ref=29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13059-016-1123-9","volume":"17","author":"Szabo L.","year":"2016","unstructured":"Szabo L.; Morey R.; Palpant N.J.; Wang P.L.; Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol 2016,17(1),263","journal-title":"Genome Biol"},{"key":"ref=30","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.biopsych.2019.07.029","volume":"87","author":"Gokool A.","year":"2020","unstructured":"Gokool A.; Anwar F.; Voineagu I.; The landscape of circular RNA expression in the human brain. Biol Psychiatry 2019. Biol Psychiatry 2020,87(3),294-304","journal-title":"Biol Psychiatry"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1038\/s41593-019-0501-5","volume":"22","author":"Dube U.","year":"2019","unstructured":"Dube U.; Del-Aguila J.L.; Li Z.; Dominantly Inherited Alzheimer Network (DIAN). An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations. Nat Neurosci 2019,22(11),1903-1912","journal-title":"Nat Neurosci"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00109-017-1582-9","volume":"95","author":"Maass P.G.","year":"2017","unstructured":"Maass P.G.; Gla Ar P.; Memczak S.; A map of human circular RNAs in clinically relevant tissues. J Mol Med (Berl) 2017,95(11),1179-1189","journal-title":"J Mol Med (Berl)"},{"key":"ref=33","first-page":"2","volume":"14","author":"Starling S.","year":"2018","unstructured":"Starling S.; Alzheimer disease: Blood-derived A\u03b2 induces AD pathology. Nat Rev Neurol 2018,14(1),2","journal-title":"Nat Rev Neurol"},{"key":"ref=34","first-page":"231","volume":"1","author":"Lonskaya I.","year":"2013","unstructured":"Lonskaya I.; Shekoyan A.R.; Hebron M.L.; Diminished parkin solubility and co-localization with intraneuronal amyloid-\u03b2 are associated with autophagic defects in Alzheimer\u2019s disease. J Alzheimers Dis 2013,1,231-247","journal-title":"J Alzheimers Dis"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neuron.2010.11.006","volume":"69","author":"Bingol B.","year":"2011","unstructured":"Bingol B.; Sheng M.; Deconstruction for reconstruction: The role of proteolysis in neural plasticity and disease. Neuron 2011,69(1),22-32","journal-title":"Neuron"},{"key":"ref=36","first-page":"307","volume":"4","author":"Lukiw J.W.","year":"2013","unstructured":"Lukiw J.W.; Circular RNA (circRNA) in Alzheimer\u2019s disease (AD). Front Genet 2013,4,307","journal-title":"Front Genet"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jagp.2012.09.005","volume":"5","author":"Tatro E.T.","year":"2013","unstructured":"Tatro E.T.; Risbrough V.; Soontornniyomkij B.; Short-term recognition memory correlates with regional CNS expression of microRNA-138 in mice. Am J Geriatr Psychiat Off J Am Assoc Geriatr Psychiat 2013,5,461-473","journal-title":"Am J Geriatr Psychiat Off J Am Assoc Geriatr Psychiat"},{"key":"ref=38","first-page":"501","volume":"8","author":"Julia S.D.","year":"2014","unstructured":"Julia S.D.; Sara A.; Marcel S.; MicroRNA-138 is a potential regulator of memory performance in humans. Front Hum Neurosci 2014,8,501","journal-title":"Front Hum Neurosci"},{"key":"ref=39","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1038\/s41380-020-0653-4","volume":"25","author":"Zimmerman A.J.","year":"2020","unstructured":"Zimmerman A.J.; Hafez A.K.; Amoah S.K.; A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Mol Psychiatry 2020,25(11),2712-2727","journal-title":"Mol Psychiatry"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.neuron.2019.08.017","volume":"104","author":"Chokshi V.","year":"2019","unstructured":"Chokshi V.; Gao M.; Grier B.D.; Input-specific metaplasticity in the visual cortex requires homer1a-mediated mGluR5 signaling. Neuron 2019,104(4),736-748.e6","journal-title":"Neuron"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.ymthe.2017.06.009","volume":"25","author":"Zhang S.","year":"2017","unstructured":"Zhang S.; Zhu D.; Li H.; Li H.; Feng C.; Zhang W.; Characterization of circRNA-associated-ceRNA networks in a senescence-accelerated mouse prone 8 brain. Mol Ther 2017,25(9),2053-2061","journal-title":"Mol Ther"},{"key":"ref=42","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.omtn.2019.10.030","volume":"18","author":"Ma N.","year":"2019","unstructured":"Ma N.; Pan J.; Ye X.; Yu B.; Zhang W.; Wan J.; Whole-transcriptome analysis of APP\/PS1 mouse brain and identification of circRNA-miRNA-mRNA networks to investigate AD pathogenesis. Mol Ther Nucleic Acids 2019,18,1049-1062","journal-title":"Mol Ther Nucleic Acids"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s13760-017-0862-z","volume":"118","author":"Patrick S.","year":"2018","unstructured":"Patrick S.; Neuromodulatory procedures for gait disorders in Parkinson\u2019s disease. Acta Neurol Belg 2018,118(1),13-19","journal-title":"Acta Neurol Belg"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"13052","DOI":"10.1073\/pnas.0906277106","volume":"106","author":"Junn E.","year":"2009","unstructured":"Junn E.; Lee K.W.; Jeong B.S.; Chan T.W.; Im J.Y.; Mouradian M.M.; Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci USA 2009,106(31),13052-13057","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"12725","DOI":"10.1523\/JNEUROSCI.0985-14.2014","volume":"34","author":"Choi D.C.","year":"2014","unstructured":"Choi D.C.; Chae Y.J.; Kabaria S.; MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA. J Neurosci 2014,34(38),12725-12737","journal-title":"J Neurosci"},{"key":"ref=46","author":"Salmena L","unstructured":"Salmena L; Poliseno L; Tay Y; Kats L; Pandolfi PP;"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1093\/nar\/gkr1009","volume":"40","author":"Danan M.","year":"2012","unstructured":"Danan M.; Schwartz S.; Edelheit S.; Sorek R.; Transcriptome-wide discovery of circular RNAs in Archaea. Nucleic Acids Res 2012,40(7),3131-3142","journal-title":"Nucleic Acids Res"},{"key":"ref=48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mcn.2012.06.001","volume":"55","author":"Cozzolino M.","year":"2013","unstructured":"Cozzolino M.; Ferri A.; Valle C.; Carr\u00ec M.T.; Mitochondria and ALS: Implications from novel genes and pathways. Mol Cell Neurosci 2013,55,44-49","journal-title":"Mol Cell Neurosci"},{"key":"ref=49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035050","volume":"7","author":"Pokrishevsky E.","year":"2012","unstructured":"Pokrishevsky E.; Grad L.I.; Yousefi M.; Wang J.; Mackenzie I.R.; Cashman N.R.; Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis. PLoS One 2012,7(4)","journal-title":"PLoS One"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1756-6606-6-31","volume":"6","author":"Nishimoto Y.","year":"2013","unstructured":"Nishimoto Y.; Nakagawa S.; Hirose T.; The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. Mol Brain 2013,6,31","journal-title":"Mol Brain"},{"key":"ref=51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","volume":"25","author":"Roos R.A.","year":"2018","unstructured":"Roos R.A.; Huntington\u2019s disease: A clinical review. Eur J Neurol 2018,25(1),24-34","journal-title":"Eur J Neurol"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nature05113","volume":"443","author":"Pollard K.S.","year":"2006","unstructured":"Pollard K.S.; Salama S.R.; Lambert N.; Lambot M.A.; Coppens S.; Pedersen J.S.; An RNA gene expressed during cortical development evolved rapidly in humans. Nature 2006,443(7108),167-172","journal-title":"Nature"},{"key":"ref=53","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/molbev\/msv031","volume":"5","author":"Xu K.","year":"2015","unstructured":"Xu K.; Schadt E.E.; Pollard K.S.; Roussos P.; Dudley J.T.; Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions. Mol Biol Evol 2015,5,1148-1160","journal-title":"Mol Biol Evol"},{"key":"ref=54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.conb.2017.12.008","volume":"48","author":"Hwang J-Y.","year":"2018","unstructured":"Hwang J-Y.; Zukin R.S.; REST, a master transcriptional regulator in neurodegenerative disease. Curr Opin Neurobiol 2018,48,193-200","journal-title":"Curr Opin Neurobiol"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1152\/physiolgenomics.00019.2010","volume":"41","author":"Johnson R.","year":"2010","unstructured":"Johnson R.; Richter N.; Jauch R.; Human accelerated region 1 noncoding RNA is repressed by REST in Huntington\u2019s disease. Physiol Genomics 2010,41(3),269-274","journal-title":"Physiol Genomics"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.molcel.2014.01.021","volume":"53","author":"Lin N.","year":"2014","unstructured":"Lin N.; Chang K.Y.; Li Z.; An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Mol Cell 2014,53(6),1005-1019","journal-title":"Mol Cell"},{"key":"ref=57","first-page":"1601","volume":"3","author":"Francelle L.","year":"2015","unstructured":"Francelle L.; Galvan L.; Gaillard M.C.; The striatal long non-coding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in-vivo. Neurobiol Aging 2015,3,1601-1607","journal-title":"Neurobiol Aging"},{"key":"ref=58","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/cr.2015.82","volume":"25","author":"Li Y.","year":"2015","unstructured":"Li Y.; Zheng Q.; Bao C.; Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res 2015,25(8),981-984","journal-title":"Cell Res"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3233\/CBM-150552","volume":"16","author":"Qin M.","year":"2016","unstructured":"Qin M.; Liu G.; Huo X.; Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark 2016,16(1),161-169","journal-title":"Cancer Biomark"},{"key":"ref=60","doi-asserted-by":"publisher","first-page":"4552","DOI":"10.1073\/pnas.84.13.4552","volume":"84","author":"Dropcho E.J.","year":"1987","unstructured":"Dropcho E.J.; Chen Y.T.; Posner J.B.; Old L.J.; Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci USA 1987,84(13),4552-4556","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"5609","DOI":"10.1158\/0008-5472.CAN-13-1568","volume":"73","author":"Hansen T.B.","year":"2013","unstructured":"Hansen T.B.; Kjems J.; Damgaard C.K.; Circular RNA and miR-7 in cancer. Cancer Res 2013,73(18),5609-5612","journal-title":"Cancer Res"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3892\/ijo.2014.2322","volume":"44","author":"Liu Z.","year":"2014","unstructured":"Liu Z.; Jiang Z.; Huang J.; miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K\/ATK and Raf\/MEK\/ERK pathways. Int J Oncol 2014,44(5),1571-1580","journal-title":"Int J Oncol"},{"key":"ref=63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001233","volume":"6","author":"Burd C.E.","year":"2010","unstructured":"Burd C.E.; Jeck W.R.; Liu Y.; Expression of linear and novel circular forms of an INK4\/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet 2010,6(12)","journal-title":"PLoS Genet"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"7369","DOI":"10.1523\/JNEUROSCI.0299-19.2019","volume":"39","author":"Wu F.","year":"2019","unstructured":"Wu F.; Han B.; Wu S.; Circular RNA TLK1 aggravates neuronal injury and neurological deficits after ischemic stroke via miR-335-3p\/TIPARP. J Neurosci 2019,39(37),7369-7393","journal-title":"J Neurosci"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.7150\/ijbs.22531","volume":"13","author":"Wang M.","year":"2017","unstructured":"Wang M.; Yu F.; Wu W.; Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity. Int J Biol Sci 2017,13(12),1497-1506","journal-title":"Int J Biol Sci"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.molcel.2017.05.022","volume":"67","author":"Chen Y.G.","year":"2017","unstructured":"Chen Y.G.; Kim M.V.; Chen X.; Sensing self and foreign circular RNAs by intron identity. Mol Cell 2017,67(2),228-238.e5","journal-title":"Mol Cell"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/ijms18091977","volume":"18","author":"He L.","year":"2017","unstructured":"He L.; Zhang A.; Xiong L.; Deep circular RNA sequencing provides insights into the mechanism underlying grass carp reovirus infection. Int J Mol Sci 2017,18(9),9","journal-title":"Int J Mol Sci"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12979-015-0042-z","volume":"12","author":"Wang Y.H.","year":"2015","unstructured":"Wang Y.H.; Yu X.H.; Luo S.S.; Han H.; Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Immun Ageing 2015,12,17","journal-title":"Immun Ageing"},{"key":"ref=69","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.imlet.2015.05.014","volume":"166","author":"Fu D.","year":"2015","unstructured":"Fu D.; Yu W.; Li M.; MicroRNA-138 regulates the balance of Th1\/Th2 via targeting RUNX3 in psoriasis. Immunol Lett 2015,166(1),55-62","journal-title":"Immunol Lett"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1750-3639.1998.tb00171.x","volume":"8","author":"Prusiner S.B.","year":"1998","unstructured":"Prusiner S.B.; The prion diseases. Brain Pathol 1998,8(3),499-513","journal-title":"Brain Pathol"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s10571-004-6920-0","volume":"24","author":"Satoh J.","year":"2004","unstructured":"Satoh J.; Yamamura T.; Gene expression profile following stable expression of the cellular prion protein. Cell Mol Neurobiol 2004,24(6),793-814","journal-title":"Cell Mol Neurobiol"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1365-2990.2008.00947.x","volume":"35","author":"Satoh J.","year":"2009","unstructured":"Satoh J.; Obayashi S.; Misawa T.; Sumiyoshi K.; Oosumi K.; Tabunoki H.; Protein microarray analysis identifies human cellular prion protein interactors. Neuropathol Appl Neurobiol 2009,35(1),16-35","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"943","DOI":"10.2217\/bmm-2016-0130","volume":"10","author":"Cui X.","year":"2016","unstructured":"Cui X.; Niu W.; Kong L.; hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder. Biomarkers Med 2016,10(9),943-952","journal-title":"Biomarkers Med"},{"key":"ref=74","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1261\/rna.034090.112","volume":"12","author":"Khodor Y.L.","year":"2012","unstructured":"Khodor Y.L.; Menet J.S.; Tolan M.; Rosbash M.; Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse. RNA 2012,12,2174-2186","journal-title":"RNA"},{"key":"ref=75","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mam.2017.11.011","volume":"60","author":"Cheng L.","year":"2018","unstructured":"Cheng L.; Zhao W.; Hill A.F.; Exosomes and their role in the intercellular trafficking of normal and disease associated prion proteins. Mol Aspects Med 2018,60,62-68","journal-title":"Mol Aspects Med"}],"container-title":["Current Alzheimer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/187841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/187841\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/187841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T19:27:33Z","timestamp":1632511653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/187841\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,24]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12,24]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1567205017666201111114928","relation":{},"ISSN":["1567-2050"],"issn-type":[{"value":"1567-2050","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,24]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}