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T-synthase (core 1 beta 1,3-\ngalactosyltransferase, C1GALT1, or T-synthase) is a key enzyme involved in O-glycosylation. Although\nT-synthase is known to be important in human tumors, the effects of T-synthase and T-antigen\non human tumor responses remain poorly defined.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>In this study, a T-synthase-specific short hairpin RNA (shRNA) or T-synthase-specific eukaryotic\nexpression vector(pcDNA3.1(+)) was transfected into murine Osteosarcoma LM8 cells to\nassess the effects of T-synthase on T cells and cytokines.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The up-regulation of T-synthase promoted the proliferation of osteosarcoma cells in vitro, but\nit promoted the proliferation of tumor initially up to 2-3 weeks but showed significant growth inhibitory\neffect after 3 weeks post-implantation in vivo. Osteosarcoma cells with high T-synthase expression\nin vitro promoted the proliferation and inhibited the apoptosis of CD8+ T cells. Further, T-synthase upregulation\npromoted CD8+ T-cell proliferation and the increased production of CD4+ T cell-derived\nIFN-\u03b3 cytokines to induce the increased tumor lethality of CTLs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our data suggest that high T-synthase expression inhibits tumor growth by improving the\nbody's anti-tumor immunity. Therefore, using this characteristic to prepare tumor cell vaccines with\nhigh immunogenicity provides a new idea for clinical immunotherapy of osteosarcoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568009622666221010105701","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T06:37:06Z","timestamp":1665556626000},"page":"265-277","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Up-regulation of Core 1 Beta 1, 3-Galactosyltransferase Suppresses Osteosarcoma\nGrowth with Induction of IFN-\u03b3 Secretion and Proliferation of\nCD8+ T Cells"],"prefix":"10.2174","volume":"23","author":[{"given":"Haidan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery Ward, The First College of Clinical Medical Sciences, China Three Gorges University,\nYichang, Wuhan Province, China"},{"name":"Ningxia Medical\nUniversity, Yinchuan, Ningxia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Hematology, The First College of Clinical Medical Sciences,\nChina Three Gorges University, Yichang, Wuhan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Ward, The First College of Clinical Medical Sciences, China Three Gorges University,\nYichang, Wuhan Province, China"},{"name":"Ningxia Medical\nUniversity, Yinchuan, Ningxia, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Cegang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Ward, The First College of Clinical Medical Sciences, China Three Gorges University,\nYichang, Wuhan Province, China"},{"name":"Department of Orthopedics, Haikou Orthopedic and Diabetes Hospital, Haikou Orthopedic\nand Diabetes Hospital of Shanghai Sixth People's Hospital, Haikou, Hainan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Ward, The First College of Clinical Medical Sciences, China Three Gorges University,\nYichang, Wuhan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Ward, The First College of Clinical Medical Sciences, China Three Gorges University,\nYichang, Wuhan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Ward, The First College of Clinical Medical Sciences, China Three Gorges University,\nYichang, Wuhan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"e27227","DOI":"10.1002\/pbc.27227","volume":"65","author":"Wedekind M.F.","year":"2018","unstructured":"Wedekind M.F.; Wagner L.M.; Cripe T.P.; Immunotherapy for osteosarcoma: Where do we go from here? 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