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LF affects millions of people in India and several other tropical and sub-tropical countries imposing a huge economic burden on governments due to disability associated loss of man-hours and for disease management. Efforts to control the infection by WHO\u2019s mass drug administration (MDA) strategy using three antifilarials diethylcarbamazine, albendazole and ivermectin are only partly successful and therefore, there is an immediate need for alternative strategies. Some of the alternative strategies being explored in laboratories are: enhancing the immune competence of host by immunomodulation, combining immunomodulation with antifilarials, identifying immunoprophylactic parasite molecules (vaccine candidates) and identifying parasite molecules that can be potential drug targets. This review focuses on the advances made in this direction.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1568026619666190618110613","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T09:45:33Z","timestamp":1561628733000},"page":"1226-1240","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Strategies to Control Human Lymphatic Filarial Infection: Tweaking Host\u2019s Immune System"],"prefix":"10.2174","volume":"19","author":[{"given":"Puvvada Kalpana","family":"Murthy","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Lucknow, University Road, Lucknow 226 007, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"489","volume":"90","year":"2014","unstructured":"Global Programme to Eliminate Lymphatic Filariasis: Progress report. 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