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Its treatment relies on a single therapeutic alternative, the praziquantel. This situation may lead to drug resistance which, in turn, made urgent the need for new antischistosomal agents. Nacylhydrazones are usually explored as good antimicrobial agents, but the vanillin-related N-acylhydrazones have never been tested by their antiparasitic potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>Herein, we report the synthesis of seven analogues, three of them unpublished, their biological investigation against Schistosoma mansoni and Target Fishing studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>The compounds were synthesized following classical synthetical approaches. The anthelmintic potential was assessed as well as their cytotoxicity profile. Confocal laser scanning microscopy and target fishing study were performed to better understand the observed antischistosomal activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Compound GPQF-407 exhibited good antischistosomal activity (47.91 \u00b5M) with suitable selectivity index (4.14). Confocal laser scanning microscopy revealed that it triggered severe tegumental destruction and tubercle disintegration. Target fishing studies pointed out some probable targets, such as the serine-threonine kinases, dihydroorotate dehydrogenases and carbonic anhydrase II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The GPQF-407 was revealed to be a promising antischistosomal agent which, besides presenting the N-acylhydrazone privileged scaffold, also could be easily synthesized on large scales from commercially available materials.<\/jats:p><\/jats:sec>","DOI":"10.2174\/1568026619666190620163237","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T13:20:11Z","timestamp":1561123211000},"page":"1241-1251","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vanillin-Related N-Acylhydrazones: Synthesis, Antischistosomal Properties and Target Fishing Studies"],"prefix":"10.2174","volume":"19","author":[{"given":"Daniela G.G.","family":"Rando","sequence":"first","affiliation":[{"name":"Grupo de Pesquisas Quimico-Farmaceuticas, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela O.L.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisas Quimico-Farmaceuticas, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais F.A.","family":"Pavani","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisas Quimico-Farmaceuticas, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisas Quimico-Farmaceuticas, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma F.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisas Quimico-Farmaceuticas, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina R.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisas Quimico-Farmaceuticas, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Departamento de Ciencias Farmaceuticas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro L.S.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Nucleo de Enteroparasitas, Instituto Adolfo Lutz, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana G.","family":"de Brito","sequence":"additional","affiliation":[{"name":"Nucleo de Pesquisa em Doencas Negligenciadas, Universidade Guarulhos, Praca Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos P.N.","family":"Silva","sequence":"additional","affiliation":[{"name":"Nucleo de Pesquisa em Doencas Negligenciadas, Universidade Guarulhos, Praca Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"Roquini","sequence":"additional","affiliation":[{"name":"Nucleo de Pesquisa em Doencas Negligenciadas, Universidade Guarulhos, Praca Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Nucleo de Pesquisa em Doencas Negligenciadas, Universidade Guarulhos, Praca Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.2174\/138161212801327310","volume":"18","author":"Beckmann S.","year":"2012","unstructured":"Beckmann S.; Leutner S.; Gouignard N.; Dissous C.; Grevelding C.G.; Protein kinases as potential targets for novel anti-schistosomal strategies. 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