{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:39:31Z","timestamp":1787510371609,"version":"build-2736575974"},"reference-count":36,"publisher":"Bentham Science Publishers Ltd.","issue":"22","funder":[{"DOI":"10.13039\/501100007520","name":"Conselho de Gest\u00e3o do Patrim\u00f4nio Gen\u00e9tico","doi-asserted-by":"publisher","award":["010627\/2011- 1"],"award-info":[{"award-number":["010627\/2011- 1"]}],"id":[{"id":"10.13039\/501100007520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2019,10,24]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Several studies have aimed to identify molecules that inhibit the toxic actions\nof snake venom phospholipases A2 (PLA2s). Studies carried out with PLA2 inhibitors (PLIs) have been\nshown to be efficient in this assignment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This work aimed to analyze the interaction of peptides derived from Bothrops atrox PLI\u03b3\n(atPLI\u03b3) with a PLA2 and to evaluate the ability of these peptides to reduce phospholipase and myotoxic\nactivities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Peptides were subjected to molecular docking with a homologous Lys49 PLA2 from B. atrox\nvenom modeled by homology. Phospholipase activity neutralization assay was performed with BthTX-II\nand different ratios of the peptides. A catalytically active and an inactive PLA2 were purified from the B.\natrox venom and used together in the in vitro myotoxic activity neutralization experiments with the peptides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The peptides interacted with amino acids near the PLA2 hydrophobic channel and the loop that\nwould be bound to calcium in Asp49 PLA2. They were able to reduce phospholipase activity and peptides\nDFCHNV and ATHEE reached the highest reduction levels, being these two peptides the best that\nalso interacted in the in silico experiments. The peptides reduced the myotubes cell damage with a highlight\nfor the DFCHNV peptide, which reduced by about 65%. It has been suggested that myotoxic activity\nreduction is related to the sites occupied in the PLA2 structure, which could corroborate the results\nobserved in molecular docking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study should contribute to the investigation of the potential of PLIs to inhibit the toxic\neffects of PLA2s.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1568026619666190725102812","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T08:26:45Z","timestamp":1571905605000},"page":"1952-1961","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antimyotoxic Activity of Synthetic Peptides Derived from Bothrops atrox Snake Gamma Phospholipase A2 Inhibitor Selected by Virtual Screening"],"prefix":"10.2174","volume":"19","author":[{"given":"J.C.","family":"Sobrinho","sequence":"first","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, FIOCRUZ, Fiocruz Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Francisco","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, FIOCRUZ, Fiocruz Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sim\u00f5es-Silva","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, FIOCRUZ, Fiocruz Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Kayano","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, FIOCRUZ, Fiocruz Rond\u00f4nia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J. 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