{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:57:50Z","timestamp":1775235470676,"version":"3.50.1"},"reference-count":34,"publisher":"Bentham Science Publishers Ltd.","issue":"2","funder":[{"DOI":"10.13039\/501100002322","name":"Coordenacao de Aperfei\u00e7oamento de Pessoal de Nivel Superior - Brasil","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2020,2,19]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>In this work DHPMs were combined with the quinoline nucleus to obtain new\nquinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds with improved antiplasmodial activity as\nwell as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected\nby a linker group to quinolone ring moieties with different substituents were synthesized and assayed\nagainst P. falciparum.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected\nby a linker group to quinoline ring moieties with different substituents were synthesized and assayed\nagainst chloroquine-resistant Plasmodium falciparum, along with the reference drug chloroquine.\nAmong these compounds, the derivatives with two methylene carbon spacers showed the best activity\naccompanied by low cytotoxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The derivative without substituents on the aromatic ring (2a) and the derivative with a chlorine\ngroup at position 4 (2d) provided the best results, with IC50 = 1.15 \u00b5M and 1.5 \u00b5M, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Compared to the parent drugs, these compounds presented marked decreases in cytotoxicity,\nwith MDL50 values over 1,000 \u00b5M and selectivity indexes of &gt;869.5 and &gt;666.6, respectively. The\nquinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione framework appears to be promising for further studies as\nan antimalarial for overcoming the burden of resistance in P. falciparum.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026619666191019100711","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T12:26:45Z","timestamp":1571920005000},"page":"99-110","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum"],"prefix":"10.2174","volume":"20","author":[{"given":"Kamilla Rodrigues","family":"Rogerio","sequence":"first","affiliation":[{"name":"Programa de Pos-Graduacao em Quimica, PGQu Instituto de Quimica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric Stephan","family":"Graebin","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural do Rio de Janeiro, Departamento de Quimica, Laboratorio de Diversidade Molecular e Quimica Medicinal, Seropedica, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Helena","family":"Pinto Domingues","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural do Rio de Janeiro, Departamento de Quimica, Laboratorio de Diversidade Molecular e Quimica Medicinal, Seropedica, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Santos","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratorio de Pesquisa em Malaria, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitoria","family":"de Souza Fernandes da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal Rural do Rio de Janeiro, Departamento de Quimica, Laboratorio de Diversidade Molecular e Quimica Medicinal, Seropedica, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Tadeu","family":"Daniel-Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratorio de Pesquisa em Malaria, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo J.M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratorio de Pesquisa em Malaria, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0146-2218","authenticated-orcid":true,"given":"Nubia","family":"Boechat","sequence":"additional","affiliation":[{"name":"Programa de Pos-Graduacao em Quimica, PGQu Instituto de Quimica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","unstructured":"World Health Organization (WHO), World Malaria Report 2018. Available at:Accessed: March 2019"},{"key":"ref=2","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade, 2019. Available at:.Accessed: July 2019"},{"key":"ref=3","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.76519","author":"Phyo A.P.","year":"2018","unstructured":"Phyo A.P.; Nosten F.;  The Artemisinin Resistance in Southeast Asia: An Imminent Global Threat to Malalaria EliminationTowards Malaria Elimination - A Leap Forward; Manguin, S 2018","journal-title":"The Artemisinin Resistance in Southeast Asia: An Imminent Global Threat to Malalaria EliminationTowards Malaria Elimination - A Leap Forward; Manguin, S"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/1475-2875-12-263","volume":"12","author":"Na-Bangchang K.","year":"2013","unstructured":"Na-Bangchang K.; Muhamad P.; Ruaengweerayut R.; Chaijaroenkul W.; Karbwang J.; Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity. Malar J 2013,12,263-276","journal-title":"Malar J"},{"key":"ref=5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058984","volume":"8","author":"Griffing S.M.","year":"2013","unstructured":"Griffing S.M.; Viana G.M.; Mixson-Hayden T.; Sridaran S.; Alam M.T.; de Oliveira A.M.; Barnwell J.W.; Escalante A.A.; Povoa M.M.; Udhayakumar V.; Historical shifts in Brazilian P. falciparum population structure and drug resistance alleles. PLoS One 2013,8(3)","journal-title":"PLoS One"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12936-018-2380-8","volume":"17","author":"Thriemer K.","year":"2018","unstructured":"Thriemer K.; Bobogare A.; Ley B.; Gudo C.S.; Alam M.S.; Anstey N.M.; Ashley E.; Baird J.K.; Gryseels C.; Jambert E.; Lacerda M.; Laihad F.; Marfurt J.; Pasaribu A.P.; Poespoprodjo J.R.; Sutanto I.; Taylor W.R.; van den Boogaard C.; Battle K.E.; Dysoley L.; Ghimire P.; Hawley B.; Hwang J.; Khan W.A.; Mudin R.N.B.; Sumiwi M.E.; Ahmed R.; Aktaruzzaman M.M.; Awasthi K.R.; Bardaji A.; Bell D.; Boaz L.; Burdam F.H.; Chandramohan D.; Cheng Q.; Chindawongsa K.; Culpepper J.; Das S.; Deray R.; Desai M.; Domingo G.; Duoquan W.; Duparc S.; Floranita R.; Gerth-Guyette E.; Howes R.E.; Hugo C.; Jagoe G.; Sariwati E.; Jhora S.T.; Jinwei W.; Karunajeewa H.; Kenangalem E.; Lal B.K.; Landuwulang C.; Le Perru E.; Lee S.E.; Makita L.S.; McCarthy J.; Mekuria A.; Mishra N.; Naket E.; Nambanya S.; Nausien J.; Duc T.N.; Thi T.N.; Noviyanti R.; Pfeffer D.; Qi G.; Rahmalia A.; Rogerson S.; Samad I.; Sattabongkot J.; Satyagraha A.; Shanks D.; Sharma S.N.; Sibley C.H.; Sungkar A.; Syafruddin D.; Talukdar A.; Tarning J.; Ter Kuile F.; Thapa S.; Theodora M.; Huy T.T.; Waramin E.; Waramori G.; Woyessa A.; Wongsrichanalai C.; Xa N.X.; Yeom J.S.; Hermawan L.; Devine A.; Nowak S.; Jaya I.; Supargiyono S.; Grietens K.P.; Price R.N.; Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group. Malar J 2018,17(1),241","journal-title":"Malar J"},{"key":"ref=7","first-page":"72","volume":"29","author":"Venanzi E.","year":"2016","unstructured":"Venanzi E.; L\u00f3pez-V\u00e9lez R.; Resistencia a los antimal\u00e1ricos. Rev Esp Quimioter 2016,29(Suppl. 1),72-75","journal-title":"Rev Esp Quimioter"},{"key":"ref=8","author":"Cowell A.N.","year":"2019","unstructured":"Cowell A.N.; Winzeler E.A.; The genomic architecture of antimalarial drug resistance. Brief Funct Genomics 2019","journal-title":"Brief Funct Genomics"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12936-019-2716-z","volume":"18","author":"Ocan M.","year":"2019","unstructured":"Ocan M.; Akena D.; Nsobya S.; Kamya M.R.; Senono R.; Kinengyere A.A.; Obuku E.A.; Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors. Malar J 2019,18(1),76","journal-title":"Malar J"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/cid\/ciw706","volume":"15,64","author":"Siqueira A.M.","year":"2017","unstructured":"Siqueira A.M.; Alencar A.C.; Melo G.C.; Magalhaes B.L.; Machado K.; Alencar Filho A.C.; Kuehn A.; Marques M.M.; Manso M.C.; Felger I.; Vieira J.L.; Lameyre V.; Daniel-Ribeiro C.T.; Lacerda M.V.; Fixed-dose artesunate-amodiaquine combination vs chloroquine for treatment of uncomplicated blood stage P. vivax infection in the Brazilian Amazon: An open-label randomized, controlled trial. Clin Infect Dis 2017,15,64(2),166-174","journal-title":"Clin Infect Dis"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/S1473-3099(18)30348-7","volume":"18","author":"Commons R.J.","year":"2018","unstructured":"Commons R.J.; Simpson J.A.; Thriemer K.; Humphreys G.S.; Abreha T.; Alemu S.G.; A\u00f1ez A.; Anstey N.M.; Awab G.R.; Baird J.K.; Barber B.E.; Borghini-Fuhrer I.; Chu C.S.; D\u2019Alessandro U.; Dahal P.; Daher A.; de Vries P.J.; Erhart A.; Gomes M.S.M.; Gonzalez-Ceron L.; Grigg M.J.; Heidari A.; Hwang J.; Kager P.A.; Ketema T.; Khan W.A.; Lacerda M.V.G.; Leslie T.; Ley B.; Lidia K.; Monteiro W.M.; Nosten F.; Pereira D.B.; Phan G.T.; Phyo A.P.; Rowland M.; Saravu K.; Sibley C.H.; Siqueira A.M.; Stepniewska K.; Sutanto I.; Taylor W.R.J.; Thwaites G.; Tran B.Q.; Tran H.T.; Valecha N.; Vieira J.L.F.; Wangchuk S.; William T.; Woodrow C.J.; Zuluaga-Idarraga L.; Guerin P.J.; White N.J.; Price R.N.; The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis. Lancet Infect Dis 2018,18(9),1025-1034","journal-title":"Lancet Infect Dis"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12936-018-2411-5","volume":"17","author":"Silva S.R.","year":"2016","unstructured":"Silva S.R.; Almeida A.C.G.; da Silva G.A.V.; Ramasawmy R.; Lopes S.C.P.; Siqueira A.M.; Costa G.L.; Sousa T.N.; Vieira J.L.F.; Lacerda M.V.G.; Monteiro W.M.; de Melo G.C.; Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon. Malar J 2016,17(1),267","journal-title":"Malar J"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.1128\/AAC.00510-08","volume":"52","author":"de Pilla Varotti F.","year":"2008","unstructured":"de Pilla Varotti F.; Botelho A.C.C.; Andrade A.A.; de Paula R.C.; Fagundes E.M.S.; Valverde A.; Mayer L.M.U.; Mendon\u00e7a J.S.; de Souza M.V.; Boechat N.; Krettli A.U.; Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate. Antimicrob Agents Chemother 2008,52(11),3868-3874","journal-title":"Antimicrob Agents Chemother"},{"key":"ref=14","author":"Boechat N.","year":"2014","unstructured":"Boechat N.; Souza M.V.N.; Valverde A.L.; Krettli A.U.;  Compounds derived from artesunate, preparation process, pharmaceutical composition and use of the respective medicine US Patent 8802701B2, 2014"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"8285","DOI":"10.3390\/molecules17078285","volume":"17","author":"Boechat N.","year":"2012","unstructured":"Boechat N.; Pinheiro L.C.S.; Silva T.S.; Aguiar A.C.; Carvalho A.S.; Bastos M.M.; Costa C.C.P.; Pinheiro S.; Pinto A.C.; Mendon\u00e7a J.S.; Dutra K.D.B.; Valverde A.L.; Santos-Filho O.A.; Ceravolo I.P.; Krettli A.U.; New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents. Molecules 2012,17(7),8285-8302","journal-title":"Molecules"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/cbdd.12321","volume":"84","author":"Boechat N.","year":"2014","unstructured":"Boechat N.; Ferreira, Mde.L.; Pinheiro, L.C.S.; Jesus, A.M.L.; Leite, M.M.M.; J\u00fanior, C.C.S.; Aguiar, A.C.C.; de Andrade, I.M.; Krettli, A.U. New compounds hybrids 1h-1,2,3-triazole-quinoline against Plasmodium falciparum. Chem Biol Drug Des 2014,84(3),325-332","journal-title":"Chem Biol Drug Des"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.1016\/j.bmc.2015.06.056","volume":"23","author":"Pinheiro L.C.S.","year":"2015","unstructured":"Pinheiro L.C.S.; Boechat N.; Ferreira, Mde.L.; J\u00fanior, C.C.S.; Jesus, A.M.L.; Leite, M.M.M.; Souza, N.B.; Krettli, A.U. Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids. Bioorg Med Chem 2015,23(17),5979-5984","journal-title":"Bioorg Med Chem"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1016\/j.bmcl.2016.03.027","volume":"26","author":"Carvalho R.C.C.","year":"2016","unstructured":"Carvalho R.C.C.; Martins W.A.; Silva T.P.; Kaiser C.R.; Bastos M.M.; Pinheiro L.C.S.; Krettli A.U.; Boechat N.; New pentasubstituted pyrrole hybrid atorvastatin-quinoline derivatives with antiplasmodial activity. Bioorg Med Chem Lett 2016,26(8),1881-1884","journal-title":"Bioorg Med Chem Lett"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"4492","DOI":"10.1016\/j.bmc.2016.07.049","volume":"24","author":"Silva T.B.","year":"2016","unstructured":"Silva T.B.; Bernardino A.M.R.; Ferreira M.L.G.; Rogerio K.R.; Carvalho L.J.M.; Boechat N.; Pinheiro L.C.S.; Design, synthesis and anti-P. falciparum activity of pyrazolopyridine-sulfonamide derivatives. Bioorg Med Chem 2016,24(18),4492-4498","journal-title":"Bioorg Med Chem"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ejmech.2016.09.073","volume":"126","author":"Azeredo L.F.S.P.","year":"2017","unstructured":"Azeredo L.F.S.P.; Coutinho J.P.; Jabor V.A.P.; Feliciano P.R.; Nonato M.C.; Kaiser C.R.; Menezes C.M.S.; Hammes A.S.O.; Caffarena E.R.; Hoelz L.V.B.; de Souza N.B.; Pereira G.A.N.; Cer\u00e1volo I.P.; Krettli A.U.; Boechat N.; Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors. Eur J Med Chem 2017,126,72-83","journal-title":"Eur J Med Chem"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.bmc.2019.01.044","volume":"27","author":"da Silva R.M.R.J.","year":"2019","unstructured":"da Silva R.M.R.J.; Gandi M.O.; Mendon\u00e7a J.S.; Carvalho A.S.; Coutinho J.P.; Aguiar A.C.C.; Krettli A.U.; Boechat N.; New hybrid trifluoromethylquinolines as antiplasmodium agents. Bioorg Med Chem 2019,27(6),1002-1008","journal-title":"Bioorg Med Chem"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"11164","DOI":"10.1021\/cr500123g","volume":"114","author":"Teixeira C.","year":"2014","unstructured":"Teixeira C.; Vale N.; P\u00e9rez B.; Gomes A.; Gomes J.R.B.; Gomes P.; \u201cRecycling\u201d classical drugs for malaria. Chem Rev 2014,114(22),11164-11220","journal-title":"Chem Rev"},{"key":"ref=23","author":"Rajab M.","year":"2018","unstructured":"Rajab M.;  Investigating Calcium Channel Blockers as Antimalarials  PhD Thesis University of Salford Salford, UK 2018","journal-title":"Investigating Calcium Channel Blockers as Antimalarials  PhD Thesis University of Salford Salford, UK"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/0035-9203(90)90004-X","volume":"84","author":"Kyle D.E.","year":"1990","unstructured":"Kyle D.E.; Oduola A.M.J.; Martin S.K.; Milhous W.K.; \n                        Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro. Trans R Soc Trop Med Hyg 1990,84(4),474-478","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref=25","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760170452","volume":"113","author":"Rogerio K.R.","year":"2018","unstructured":"Rogerio K.R.; Carvalho L.J.M.; Domingues L.H.P.; Neves B.J.; Moreira Filho J.T.; Castro R.N.; Bianco J\u00fanior C.; Daniel-Ribeiro C.T.; Andrade C.H.; Graebin C.S.; Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds. Mem Inst Oswaldo Cruz 2018,113(8)","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2174\/1389557013407188","volume":"1","author":"Egan T.J.","year":"2001","unstructured":"Egan T.J.; Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials. Mini Rev Med Chem 2001,1(1),113-123","journal-title":"Mini Rev Med Chem"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1021\/cc0200181","volume":"4","author":"P\u00e9rez R.","year":"2002","unstructured":"P\u00e9rez R.; Beryozkina T.; Zbruyev O.I.; Haas W.; Kappe C.O.; Traceless solid-phase synthesis of bicyclic dihydropyrimidones using multidirectional cyclization cleavage. J Comb Chem 2002,4(5),501-510","journal-title":"J Comb Chem"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1078\/094471103322331458","volume":"10","author":"B\u00e9zivin C.","year":"2003","unstructured":"B\u00e9zivin C.; Tomasi S.; Loh\u00e9zic-Le D\u00e9v\u00e9hat F.; Boustie J.; Cytotoxic activity of some lichen extracts on murine and human cancer cell lines. Phytomedicine 2003,10(6-7),499-503","journal-title":"Phytomedicine"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager W.","year":"1976","unstructured":"Trager W.; Jensen J.B.; Human malaria parasites in continuous culture. Science 1976,193(4254),673-675","journal-title":"Science"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"418","DOI":"10.2307\/3280287","volume":"65","author":"Lambros C.","year":"1979","unstructured":"Lambros C.; Vanderberg J.P.; Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 1979,65(3),418-420","journal-title":"J Parasitol"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0014-4894(03)00051-1","volume":"102","author":"Noedl H.","year":"2002","unstructured":"Noedl H.; Wongsrichanalai C.; Miller R.S.; Myint K.S.; Looareesuwan S.; Sukthana Y.; Wongchotigul V.; Kollaritsch H.; Wiedermann G.; Wernsdorfer W.H.; \n                        Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II. Exp Parasitol 2002,102(3-4),157-163","journal-title":"Exp Parasitol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"Denizot F.","year":"1986","unstructured":"Denizot F.; Lang R.; Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986,89(2),271-277","journal-title":"J Immunol Methods"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.bbrc.2010.10.108","volume":"402","author":"Wang C.","year":"2010","unstructured":"Wang C.; Qin X.; Huang B.; He F.; Zeng C.; Hemolysis of human erythrocytes induced by melamine-cyanurate complex. Biochem Biophys Res Commun 2010,402(4),773-777","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1056-8719(02)00206-X","volume":"47","author":"Lucisano-Valim Y.M.","year":"2002","unstructured":"Lucisano-Valim Y.M.; Kabeya L.M.; Kanashiro A.; Russo-Carbolante E.M.; Polizello A.C.; Azzolini A.E.; Silva S.C.; Lopes J.L.; de Oliveira C.A.; Mantovani B.; A simple method to study the activity of natural compounds on the chemiluminescence of neutrophils upon stimulation by immune complexes. J Pharmacol Toxicol Methods 2002,47(1),53-58","journal-title":"J Pharmacol Toxicol Methods"}],"container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/eurekaselect.com\/article\/download\/175877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T13:55:46Z","timestamp":1583762146000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.eurekaselect.com\/175877\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,19]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,19]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1568026619666191019100711","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2,19]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2019-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}