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Their advantages and disadvantages\nwill also be discussed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Anesthesia is a relatively young field but is rapidly evolving. Currently used general anesthetics\nare almost invariably effective, but nagging side effects, both short (e.g., cardiac depression) and long\n(e.g., neurotoxicity) term, have reawakened the call for new drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Based on the deepening understanding of historical development and molecular targets and\nactions of modern anesthetics, novel general anesthetics are being investigated as potentially improved\nsedative-hypnotics or a key to understand the mechanism of anesthesia.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026619666191114101425","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T08:30:39Z","timestamp":1573720239000},"page":"2842-2854","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mechanism and Development of Modern General Anesthetics"],"prefix":"10.2174","volume":"19","author":[{"given":"Xiaoxuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Luethy","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"281","volume":"8","author":"Ohry A.","year":"1983","unstructured":"Ohry A.; A short history of anaesthesia. 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