{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:50:29Z","timestamp":1740142229417,"version":"3.37.3"},"reference-count":38,"publisher":"Bentham Science Publishers Ltd.","issue":"9","funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["604102"],"award-info":[{"award-number":["604102"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2020,5,17]]},"abstract":"<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>Ischemic stroke affects language production and\/or comprehension and leads to\ndevastating long-term consequences for patients and their families. Previous studies have shown that\nneuroimaging can increase our knowledge of the basic mechanisms of language recovery. Currently,\nmodels for predicting patients\u2019 outcomes have limited use in the clinic for the evaluation and optimization\nof rehabilitative strategies mostly because that are often based on high-resolution magnetic resonance\nimaging (MRI) data, which are not always possible to carry out in the clinical routine. Here, we\ninvestigate the use of Voxel-Based Morphometry (VBM), multivariate modelling and native Computed\nTomography (nCT) scans routinely acquired in the acute stage of stroke for identifying biological signatures\nthat explicate the relationships between brain anatomy and types of impairments.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>80 stroke patients and 30 controls were included. nCT-scans were acquired in the acute\nischemia stage and bedside clinical assessment from board-certified neurologist based on the NIH stroke\nscale. We use a multivariate Principal Component Analyses (PCA) to identify the brain signatures group\nthe patients according to the presence or absence of impairment and identify the association between\nlocal Grey Matter (GM) and White Matter (WM) nCT values with the presence or absence of the impairment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Individual patient\u2019s nCT scans were compared to a group of controls\u2019 with no radiological\nsigns of stroke to provide an automated delineation of the lesion. Consistently across the whole group\nthe regions that presented significant difference GM and WM values overlap with known areas that support\nlanguage processing.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> In summary, the method applied to nCT scans performed in the acute stage of stroke provided\nrobust and accurate information about brain lesions\u2019 location and size, as well as quantitative values.\nWe found that nCT and VBQ analyses are effective for identifying neural signatures of concomitant\nlanguage impairments at the individual level, and neuroanatomical maps of aphasia at the population\nlevel. The signatures explicate the neurophysiological mechanisms underlying aetiology of the stroke.\nUltimately, similar analyses with larger cohorts could lead to a more integrated multimodal model of\nbehaviour and brain anatomy in the early stage of ischemic stroke.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026620666200211113824","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T14:51:53Z","timestamp":1581432713000},"page":"792-799","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuro-Clinical Signatures of Language Impairments after Acute Stroke: A VBQ Analysis of Quantitative Native CT Scans"],"prefix":"10.2174","volume":"20","author":[{"given":"Sandrine","family":"Muller","sequence":"first","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaisar","family":"Dauyey","sequence":"additional","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Ruef","sequence":"additional","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lorio","sequence":"additional","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Eskandari","sequence":"additional","affiliation":[{"name":"Stroke Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Schneider","sequence":"additional","affiliation":[{"name":"Service de Neuropsychologie et Neurorehabilitation, Departement des Neurosciences Cliniques, CHUV, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Beaud","sequence":"additional","affiliation":[{"name":"Service de Neuropsychologie et Neurorehabilitation, Departement des Neurosciences Cliniques, CHUV, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Roggenhofer","sequence":"additional","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Draganski","sequence":"additional","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Michel","sequence":"additional","affiliation":[{"name":"Stroke Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferath","family":"Kherif","sequence":"additional","affiliation":[{"name":"Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"E52","DOI":"10.1002\/ccd.24862","volume":"82","author":"Sacks D.","year":"2013","unstructured":"Sacks D.; Black C.M.; Cognard C.; Connors J.J.; Frei D.; Gupta R.; Jovin T.G.; Kluck B.; Meyers P.M.; Murphy K.J.; Ramee S.; R\u00fcfenacht D.A.; Stallmeyer M.J.B.; Vorwerk D.; American Society of Acute Ischemic Stroke; Canadian Interventional Radiology Society; Cardiovascular and Interventional Radiological Society of Europe; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology; Society of NeuroInterventional Surgery; European Society of Minimally Invasive Neurological Therapy; Society of Vascular and Interventional Neurology. Multisociety consensus quality improvement guidelines for intraarterial catheter-directed treatment of acute ischemic stroke, from the American Society of Neuroradiology, Canadian Interventional Radiology Association, Cardiovascular and Interventional Rad. Catheter Cardiovasc Interv 2013,82(2),E52-E68","journal-title":"Catheter Cardiovasc Interv"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S1474-4422(09)70025-0","volume":"8","author":"Feigin V.L.","year":"2009","unstructured":"Feigin V.L.; Lawes C.M.M.; Bennett D.A.; Barker-Collo S.L.; Parag V.; Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. 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Lancet 2000,355(9216),1670-1674","journal-title":"Lancet"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1161\/STROKEAHA.108.192616","volume":"40","author":"Latchaw R.E.","year":"2009","unstructured":"Latchaw R.E.; Alberts M.J.; Lev M.H.; Connors J.J.; Harbaugh R.E.; Higashida R.T.; Hobson R.; Kidwell C.S.; Koroshetz W.J.; Mathews V.; Villablanca P.; Warach S.; Walters B.; Recommendations for imaging of acute ischemic stroke: a scientific statement from the American Heart Association. Stroke American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, and the Interdisciplinary Council on Peripheral Vascular Disease2009,40(11),3646-3678","journal-title":"Stroke"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/brb3.146","volume":"3","author":"Imabayashi E.","year":"2013","unstructured":"Imabayashi E.; Matsuda H.; Tabira T.; Arima K.; Araki N.; Ishii K.; Yamashita F.; Iwatsubo T.; Japanese alzheimer\u2019s disease neuroimaging initiative. comparison between brain ct and mri for voxel-based morphometry of alzheimer\u2019s disease. Brain Behav 2013,3(4),487-493","journal-title":"Brain Behav"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nn1050","volume":"6","author":"Bates E.","year":"2003","unstructured":"Bates E.; Wilson S.M.; Saygin A.P.; Dick F.; Sereno M.I.; Knight R.T.; Dronkers N.F.; Voxel-based lesion-symptom mapping. 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