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Starting from compound 2 the relevant S-alkylated derivatives\nof pyrido[3',2':4,5]furo(thieno)[3,2-d]pyrimidines 6 were also synthesized.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>All the compounds showed antibacterial activity to non-resistant strains. Compounds 3a-3m\nshowed antibacterial activity with MIC\/MBC at 0.08-2.31 mg\/mL\/0.11-3.75 mg\/mL .The two most active\ncompounds, 3j and 6b, appeared to be more active towards MRSA than the reference drugs. Half of the\ntested compounds appeared to be equipotent\/more potent than ketoconazole and more potent than bifonazole.\nThe docking analysis provided useful information about the interactions occurring between the tested\ncompounds and the different enzymes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Gram-negative and Gram-positive bacteria and fungi showed different response towards\ntested compounds, indicating that different substituents may lead to different modes of action or that the\nmetabolism of some bacteria\/fungi was better able to overcome the effect of the compounds or adapt to it.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026620666200628145308","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T17:03:25Z","timestamp":1593450205000},"page":"2192-2209","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis and Evaluation of Antimicrobial Activity and Molecular Docking of New N-1,3-thiazol-2-ylacetamides of Condensed Pyrido[3',2':4,5] furo(thieno)[3,2-d]pyrimidines"],"prefix":"10.2174","volume":"20","author":[{"given":"Samuel N.","family":"Sirakanyan","sequence":"first","affiliation":[{"name":"Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Science of RA, 26 Azatutian Ave., Yerevan 0014, Armenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor G.","family":"Kartsev","sequence":"additional","affiliation":[{"name":"InterBioScreen, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Geronikaki","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki, School of Pharmacy, Thessaloniki, 54124, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Chemistry G. 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