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One\ndownside of this approach is that they also target other rapidly dividing healthy cells, such as those involved\nin hair growth leading to serious toxic side effects and hair loss. Therefore, it would be better to\ndevelop novel agents that address cellular signaling mechanisms unique to cancerous cells, and new research\nis now focussing on such approaches. Although the classical chemotherapy area involving DNA\nas the set target continues to produce important findings, nevertheless, a distinctly discernible emerging\ntrend is the divergence from the cisplatin operation model that uses the metal as the primary active center\nof the drug. Many successful anti-cancer drugs present are associated with elevated toxicity levels.\nCancers also develop immunity against most therapies and the area of cancer research can, therefore, be\nseen as an area with a high unaddressed need. Hence, ongoing work into cancer pathogenesis is important\nto create accurate preclinical tests that can contribute to the development of innovative drugs to\nmanage and treat cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>Some of the emergent frontiers utilizing different approaches include nanoparticles delivery, use of\nquantum dots, metal complexes, tumor ablation, magnetic hypothermia and hyperthermia by use of Superparamagnetic\nIron oxide Nanostructures, pathomics and radiomics, laser surgery and exosomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>This review summarizes these new approaches in good detail, giving critical views with necessary comparisons.\nIt also delves into what they carry for the future, including their advantages and disadvantages.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026620666200819160213","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T08:15:12Z","timestamp":1597911312000},"page":"28-47","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Beyond DNA-targeting in Cancer Chemotherapy. 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