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Both TSC1\nand TSC2 are involved in several protein-protein interactions, which play a significant role in maintaining\ncellular homeostasis. The recent biochemical, genetic, structural biology, clinical and drug discovery\nadvancements on TSC give a useful insight into the disease as well as the molecular aspects of TSC1\nand TSC2. The complex nature of TSC disease, a wide range of manifestations, mosaicism and several\nother factors limits the treatment choices. This review is a compilation of the course of TSC, starting\nfrom its discovery to the current findings that would take us a step ahead in finding a cure for TSC.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026620666200825170355","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T06:28:01Z","timestamp":1598423281000},"page":"2080-2093","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Insight of Scientific Developments in TSC for Better Therapeutic Strategy"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3953-9938","authenticated-orcid":true,"given":"Nalini","family":"Natarajan","sequence":"first","affiliation":[{"name":"Discipline of Biological Engineering, Indian Institute of Technology Gandhinagar, Gujarat-382355, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-7626","authenticated-orcid":true,"given":"Vijay","family":"Thiruvenkatam","sequence":"additional","affiliation":[{"name":"Discipline of Biological Engineering, Indian Institute of Technology Gandhinagar, Gujarat-382355, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/088307389200700219","volume":"7","author":"Roach E.S.","year":"1992","unstructured":"Roach E.S.; Smith M.; Huttenlocher P.; Bhat M.; Alcorn D.; Hawley L.; Diagnostic criteria: tuberous sclerosis complex. report of the diagnostic criteria committee of the national tuberous sclerosis association. 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