{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:46:33Z","timestamp":1769586393205,"version":"3.49.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"32","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2020,12,3]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>The manipulation of an individual\u2019s genetic information to treat a disease has revolutionized\nthe biomedicine field. Despite the promise of gene therapy, this treatment can have long-term sideeffects.\nEfforts in the field and recent discoveries have already led to several improvements, including\nefficient gene delivery and transfer, as well as inpatient safety. Several studies to treat a wide range of\npathologies-such as cancer or monogenic diseases- are currently being conducted. Here we provide a\nbroad overview of methodologies available for gene therapy, placing a strong emphasis on treatments\nfor central nervous system diseases. Finally, we give a perspective on current delivery strategies to treat\nsuch diseases, with a special focus on systems that use peptides as delivery vectors.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026620666201023122903","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T04:06:02Z","timestamp":1603685162000},"page":"2945-2958","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peptide Shuttle-Mediated Delivery for Brain Gene Therapies"],"prefix":"10.2174","volume":"20","author":[{"given":"Josep","family":"Garcia","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pol","family":"Arranz-Gibert","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena","family":"S\u00e1nchez-Navarro","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Giralt","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Teixid\u00f3","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/187149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:14:47Z","timestamp":1607055287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/187149\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":0,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2020,12,3]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1568026620666201023122903","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}