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According to the\nlatest World malaria report, there were 229 million cases of malaria in 2019 majorly consist of children\nunder 5 years of age. Some of known analogues viz. quinine, quinoline-containing compounds\nhave been used for last century in the clinical treatment of malaria. Past few decades witnessed the\nemergence of multi-drug resistance (MDR) strains of Plasmodium species to existing antimalarials\npressing the need for new drug candidates. Thus, in those decades bioorganometallic approach to\nmalaria therapy has been introduced which led to the discovery of noval metalcontaining aminoquinolines\nanalogues viz. ferroquine (FQ or 1), Ruthenoquine (RQ or 2) and other related potent metalanalogues.\nIt observed that some metal containing analogues (Fe-, Rh-, Ru-, Re-, Au-, Zn-, Cr-, Pd-,\nSn-, Cd-, Ir-, Co-, Cu-, and Mn-aminoquines) were more potent; however, some were equally potent\nas Chloroquine (CQ) and 1. This is probably due to the intertion of metals in the CQ via various approaches,\nwhich might be a very attractive strategy to develop a SAR of novel metal containing antimalarials.\nThus, this review aim to summarize the SAR of metal containing aminoquines towards the\ndiscovery of potent antimalarial hybrids to provide an insight for rational designs of more effective\nand less toxic metal containing amonoquines.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026622666220105103751","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T07:34:18Z","timestamp":1641454458000},"page":"436-472","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Structural-activity Relationship of Metallo-aminoquines as Next\nGeneration Antimalarials"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-8451","authenticated-orcid":true,"given":"Mohammad","family":"Abid","sequence":"first","affiliation":[{"name":"Department of Biosciences, Jamia Millia Islamia University, Jamia Nagar, New Delhi, 110025, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailja","family":"Singh","sequence":"additional","affiliation":[{"name":"Special Centre\nfor Molecular Medicine, Jawaharlal Nehru University, New Mehroli Road, New Delhi, 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-8473","authenticated-orcid":true,"given":"Timothy J.","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of\nChemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-8871","authenticated-orcid":true,"given":"Mukesh C.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Motilal\nNehru College, University of Delhi, Benito Juarez marg, South Campus, New Delhi, 110021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cbpa.2012.01.013","volume":"16","author":"Gasser G.","year":"2012","unstructured":"Gasser G.; Metzler-Nolte N.; The potential of organometallic complexes in medicinal chemistry. 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