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A growing number of studies confirm that neuroprotective\nmeasures should be maintained in COVID-19 patients. On the other hand, cannabinoids have been\nthe subject of various studies that propose them as potentially promising drugs in chronic neurodegenerative\ndiseases due to their powerful neuroprotective potential. In this review, we addresses\nthe possible mechanism of action of cannabinoids as a neuroprotective treatment in patients infected\nby SARS-CoV-2. The endocannabinoid system is found in multiple systems within the body, including\nthe immune system. Its activation can lead to beneficial results, such as a decrease in viral\nentry, a reduction of viral replication, and a reduction of pro-inflammatory cytokines such as IL-2,\nIL-4, IL-6, IL-12, TNF-\u03b1, or IFN-c through CB2R expression induced during inflammation by\nSARS-CoV-2 infection in the central nervous system.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026622666220405143003","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T06:49:05Z","timestamp":1649227745000},"page":"1326-1345","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Potential Neuroprotective Effect of Cannabinoids in COVID-19 Patients"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-8535","authenticated-orcid":true,"given":"Jos\u00e9 Luis","family":"Cortes-Altamirano","sequence":"first","affiliation":[{"name":"Division de Neurociencias, Instituto Nacional de Rehabilitaci\u00f3n, Secretar\u00eda de Salud, Mexico City, 14389, Mexico"},{"name":"Departamento de Quiropr\u00e1ctica, Universidad Estatal del Valle de Ecatepec, Estado de Mexico, 55210, Mexico."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1404-2263","authenticated-orcid":true,"given":"Ariadna","family":"Y\u00e1\u00f1ez-Piza\u00f1a","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias de la Salud, Medicina Veterinaria y Zootecnia, Universidad del Valle de Mexico, Mexico City, 04910, M\u00e9xico"},{"name":"Escuela de Medicina Veterinaria y Zootecnia en Peque\u00f1as Especies, Federaci\u00f3n Canofila Mexicana, Mexico City, 14430, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-0814","authenticated-orcid":true,"given":"Samuel","family":"Reyes-Long","sequence":"additional","affiliation":[{"name":"Division de Neurociencias, Instituto Nacional de Rehabilitaci\u00f3n, Secretar\u00eda de Salud, Mexico City, 14389, Mexico"},{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City, 07738, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-9146","authenticated-orcid":true,"given":"Gonz\u00e1lez-Maciel","family":"Ang\u00e9lica","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Tissue Morphology, Instituto Nacional de Pediatr\u00eda, Secretar\u00eda de Salud, Insurgentes Sur No. 3700-C, Mexico City, C. 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