{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:46:52Z","timestamp":1791931612836,"version":"4.3.4"},"reference-count":122,"publisher":"Bentham Science Publishers Ltd.","issue":"13","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Alzheimer\u2019s disease (AD) remains one of the major neurodegenerative diseases over-whelming the world today. Alzheimer\u2019s is the most complicated as well as perplexing disease en-countering serious global health issues. Alzheimer\u2019s disease is well characterized as a general cause of dementia, which includes issues with memory, language, problem-solving, and other cognitive behaviours, such as disabled perception as well as trouble talking due to degeneration of neurons. According to the latest report, there are about 44 million individuals who are currently suffering from dementia, which has been prophesied to extensively grow up to 3-fold by 2050. Alzheimer\u2019s disease is usually triggered by numerous associated factors, including depleted amount of acetyl-choline (ACh), excessive aggregation of \u03b2-amyloid peptide (A\u03b2), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). Besides these superior factors, sometimes AD can be induced or become complex due to several reasons, such as inflammatory mechanisms and oxidative stress. Furthermore, heterocyclic scaffolds comprise assorted implications in the drug design and devel-opment process. Heterocycles have also elicited their evolving role as core scaffolds in numerous synthetic derivatives with potent anti-Alzheimer\u2019s potential. There are only limited drugs that are present in the market to treat Alzheimer\u2019s disease in an efficacious manner. Hence, the identifica-tion, design, and development of new anti-Alzheimer\u2019s drugs are an emerging need to eradicate complex clinical indications associated with Alzheimer\u2019s disease. This review aims to summarize various recent advancements in the medicinal chemistry of heterocycle-based compounds with the following objectives: (1) to represent inclusive literature reports describing the anti-Alzheimer\u2019s po-tential of heterocyclic derivatives; (2) to cast light on recent advancements in the medicinal chemis-try of heterocyclic compounds endowed with therapeutic potential against Alzheimer\u2019s disease; (3) to summarize the comprehensive correlation of structure-activity relationship (SAR) with the phar-macological responses, including in silico and mechanistic studies to provide ideas related to design and development of lead molecules.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1568026623666221019152502","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T11:57:37Z","timestamp":1666267057000},"page":"1277-1306","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recent Advances in the Development of Nitrogen-containing Heterocyclic\nAnti-alzheimer\u2019s Agents"],"prefix":"10.2174","volume":"23","author":[{"given":"Pooja A.","family":"Chawla","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, 142001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupender","family":"Nehra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical\nSciences, Lord Shiva College of Pharmacy, Sirsa, Haryana, 125055, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, ISF\nCollege of Pharmacy, Moga, 142001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poona College of Pharmacy,\nBharati VidyaPeeth University, Pune, Maharashtra, 411038, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1021\/jm049112h","volume":"48","author":"Rosini M.","year":"2005","unstructured":"Rosini M.; Andrisano V.; Bartolini M.; Bolognesi M.L.; Hrelia P.; Minarini A.; Tarozzi A.; Melchiorre C.; Rational approach to discover multipotent anti-Alzheimer drugs. 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