{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:59:53Z","timestamp":1788184793992,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"8","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CN"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>According to the World Health Organization (WHO), 47 million people display mental\nhealth disorders Worldwide. In addition, epidemiological studies have shown that the extension of life\nexpectancy and the increase in aged population will significantly impact the prevalence of several\nmental impairments. Although there are strategies for preventing and alleviating mental illnesses, such\nas pharmacological and psychological approaches, limited results have been observed. Thus, the search\nfor new therapeutics for managing psychiatric disorders has explored multiple roads. In recent years, it\nhas been demonstrated that physical activity and exercise promote health benefits. On the other hand,\namong the neurobiological systems that participate in the genesis and development of mental disruptions,\nthe endocannabinoid system has been suggested as an active player. Supporting this hypothesis,\ndata suggest that the elements comprising the endocannabinoid system, such as the CB&lt;sub&gt;1&lt;\/sub&gt;\/CB&lt;sub&gt;2&lt;\/sub&gt; cannabinoid\nreceptors, endogenous ligands (N-arachidonoylethanolamine [anandamide, AEA] and 2-\narachidonoylglycerol [2-AG]), transporters and the enzymes involved in the biosynthesis and degradation\nof the AEA and 2-AG, modulate mental diseases. In this review, we discuss that the endocannabinoid\nsystem might be considered as a modulator for the positive outcomes of exercise in the management\nof mental disorders. Clinically, this promising field might be exploited by targeting the elements\nof the endocannabinoid system aimed to increase the exercise benefits applied to patients with\nmental illnesses.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/1570159x19666201218112748","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T05:56:05Z","timestamp":1608530165000},"page":"1304-1322","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health"],"prefix":"10.2174","volume":"19","author":[{"given":"Sandra","family":"Amatriain-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Faculty of Sport Sciences and Physical Education, University of A Coruna, A Coruna,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Budde","sequence":"additional","affiliation":[{"name":"Faculty of Human Sciences, Medical School Hamburg. Hamburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gronwald","sequence":"additional","affiliation":[{"name":"Department of Performance, Neuroscience, Therapy and Health, Faculty of Health Sciences, Medical School Hamburg, Hamburg,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Carre\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Viana-Torre","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Imperatori","sequence":"additional","affiliation":[{"name":"Cognitive and Clinical Psychology Laboratory, Department of Human Sciences European University of Rome, Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Sports Methods and Techniques, Federal University of Santa Maria. Santa Maria,Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Murillo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan,Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Neuropharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1570159X19666201218112748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/189240\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/1570159X19666201218112748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T13:24:11Z","timestamp":1655385851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/189240\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/1570159x19666201218112748","relation":{},"ISSN":["1570-159X"],"issn-type":[{"value":"1570-159X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2020-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}