{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:52:43Z","timestamp":1793987563418,"version":"4.8.0"},"reference-count":68,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CVP"],"published-print":{"date-parts":[[2020,1,27]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) has emerged as a pandemic. It has different\ncomplications, both microvascular and macrovascular.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this review is to summarize the different types of macrovascular complications\nassociated with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive review of the literature was performed to identify clinical studies, which\ndetermine the macrovascular complications associated with T2DM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Macrovascular complications of T2DM include coronary heart disease, cardiomyopathy, arrhythmias\nand sudden death, cerebrovascular disease and peripheral artery disease. Cardiovascular disease\nis the primary cause of death in diabetic patients. Many clinical studies have shown a connection\nbetween T2DM and vascular disease, but almost always other risk factors are present in diabetic patients,\nsuch as hypertension, obesity and dyslipidaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>T2DM causes a variety of macrovascular complications through different pathogenetic\npathways that include hyperglycaemia and insulin resistance. The association between T2DM and cardiovascular\ndisease is clear, but we need more clinical studies in order to identify the pure effect of\nT2DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/1570161117666190405165151","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T06:30:04Z","timestamp":1554791404000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":358,"title":["Macrovascular Complications of Type 2 Diabetes Mellitus"],"prefix":"10.2174","volume":"18","author":[{"given":"Margus","family":"Viigimaa","sequence":"first","affiliation":[{"name":"Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia; Institute of Health Technologies, Tallinn University of Technology, Tallinn, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Sachinidis","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Toumpourleka","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Koutsampasopoulos","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Alliksoo","sequence":"additional","affiliation":[{"name":"Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia; Institute of Health Technologies, Tallinn University of Technology, Tallinn, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Titma","sequence":"additional","affiliation":[{"name":"Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia; Institute of Health Technologies, Tallinn University of Technology, Tallinn, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","year":"2016","unstructured":"Global report on diabetes. 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